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ZNF425 zinc finger protein 425 [ Homo sapiens (human) ]

Gene ID: 155054, updated on 5-Jan-2022

Summary

Official Symbol
ZNF425provided by HGNC
Official Full Name
zinc finger protein 425provided by HGNC
Primary source
HGNC:HGNC:20690
See related
Ensembl:ENSG00000204947 MIM:619507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in ovary (RPKM 1.8), brain (RPKM 1.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF425 in Genome Data Viewer
Location:
7q36.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (149102784..149126324, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148799876..148823416, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 1 Neighboring gene zinc finger protein 786 Neighboring gene RNA, 7SL, cytoplasmic 521, pseudogene Neighboring gene zinc finger protein 398 Neighboring gene uncharacterized LOC107986856 Neighboring gene centrosomal protein 83kDa pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF786

Homology

Clone Names

  • MGC150568

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001661.3NP_001001661.1  zinc finger protein 425

    See identical proteins and their annotated locations for NP_001001661.1

    Status: VALIDATED

    Source sequence(s)
    AC073422, AY621067
    Consensus CDS
    CCDS34773.1
    UniProtKB/Swiss-Prot
    Q6IV72
    UniProtKB/TrEMBL
    A0A090N7U3
    Related
    ENSP00000367300.2, ENST00000378061.7
    Conserved Domains (6) summary
    smart00349
    Location:964
    KRAB; krueppel associated box
    COG5048
    Location:355731
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:948
    KRAB; KRAB box
    pfam13465
    Location:401423
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    149102784..149126324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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