Format

Send to:

Choose Destination

AMOT angiomotin [ Homo sapiens (human) ]

Gene ID: 154796, updated on 25-Nov-2020

Summary

Official Symbol
AMOTprovided by HGNC
Official Full Name
angiomotinprovided by HGNC
Primary source
HGNC:HGNC:17810
See related
Ensembl:ENSG00000126016 MIM:300410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues See more
Orthologs

Genomic context

See AMOT in Genome Data Viewer
Location:
Xq23
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (112774877..112840945, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (112018105..112084136, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 1 Neighboring gene high mobility group box 3 pseudogene 30 Neighboring gene microRNA 4329 Neighboring gene uncharacterized LOC107985651 Neighboring gene RNA, 7SL, cytoplasmic 266, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of angiomotin (AMOT) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Angiomotin (AMOT) depletion inhibits HIV-1 Gag release from cells, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
gag Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner from 293T, HeLa, and Jurkat cells PubMed
gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
angiostatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012628.1 RefSeqGene

    Range
    4985..71313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113490.2NP_001106962.1  angiomotin isoform 1

    See identical proteins and their annotated locations for NP_001106962.1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS48154.1
    UniProtKB/Swiss-Prot
    Q4VCS5
    Related
    ENSP00000361027.3, ENST00000371959.7
    Conserved Domains (2) summary
    pfam12240
    Location:599802
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:457638
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001386998.1NP_001373927.1  angiomotin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004827
  3. NM_001386999.1NP_001373928.1  angiomotin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004827
  4. NM_133265.5NP_573572.1  angiomotin isoform 2

    See identical proteins and their annotated locations for NP_573572.1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS14563.1
    UniProtKB/Swiss-Prot
    Q4VCS5
    Related
    ENSP00000305557.1, ENST00000304758.5
    Conserved Domains (1) summary
    pfam12240
    Location:190393
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    112774877..112840945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029289.1XP_016884778.1  angiomotin isoform X2

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (1) summary
    pfam12240
    Location:190393
    Angiomotin_C; Angiomotin C terminal
  2. XM_005262090.1XP_005262147.1  angiomotin isoform X2

    See identical proteins and their annotated locations for XP_005262147.1

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (1) summary
    pfam12240
    Location:190393
    Angiomotin_C; Angiomotin C terminal
Support Center