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CYLD CYLD lysine 63 deubiquitinase [ Homo sapiens (human) ]

Gene ID: 1540, updated on 10-Oct-2020

Summary

Official Symbol
CYLDprovided by HGNC
Official Full Name
CYLD lysine 63 deubiquitinaseprovided by HGNC
Primary source
HGNC:HGNC:2584
See related
Ensembl:ENSG00000083799 MIM:605018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
Summary
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 13.0), lymph node (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See CYLD in Genome Data Viewer
Location:
16q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (50742086..50801935)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50775961..50835847)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927272 Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene uncharacterized LOC102724907 Neighboring gene microRNA 3181 Neighboring gene uncharacterized LOC105371251 Neighboring gene long intergenic non-protein coding RNA 2168 Neighboring gene VISTA enhancer hs162

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Brooke-Spiegler syndrome
MedGen: C1857941 OMIM: 605041 GeneReviews: CYLD Cutaneous Syndrome
Compare labs
Cylindromatosis, familial
MedGen: C1851526 OMIM: 132700 GeneReviews: CYLD Cutaneous Syndrome
Compare labs
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
GeneReviews: Not available
Familial multiple trichoepitheliomata
MedGen: C1275122 OMIM: 601606 GeneReviews: CYLD Cutaneous Syndrome
Compare labs
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CYLD by siRNA enhances HIV-1 infection in a single-cycle assay in HEK 293T cells, and the CYLD catalytic mutant C698A fails to reduce HIV-1 infection in 293T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 transcription increases upon CYLD knockdown in CD4+ T lymphocytes, leading to upregulation of HIV-1 Gag/p24 levels in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • HSPC057, FLJ20180, FLJ31664, FLJ78684, KIAA0849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Lys48-specific deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
Lys63-specific deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Lys63-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Lys63-specific deubiquitinase activity TAS
Traceable Author Statement
more info
 
proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein linear deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ripoptosome assembly involved in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
ciliary tip ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with midbody IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD
Names
cylindromatosis (turban tumor syndrome)
deubiquitinating enzyme CYLD
probable ubiquitin carboxyl-terminal hydrolase CYLD
ubiquitin specific peptidase like 2
ubiquitin thioesterase CYLD
ubiquitin thiolesterase CYLD
ubiquitin-specific-processing protease CYLD
NP_001035814.1
NP_001035877.1
NP_001365672.1
NP_001365673.1
NP_001365674.1
NP_001365675.1
NP_001365676.1
NP_001365677.1
NP_001365678.1
NP_001365679.1
NP_001365680.1
NP_001365681.1
NP_001365682.1
NP_001365683.1
NP_001365684.1
NP_056062.1
XP_011521213.1
XP_016878467.1
XP_016878469.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012061.1 RefSeqGene

    Range
    5001..64886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_491

mRNA and Protein(s)

  1. NM_001042355.2NP_001035814.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    See identical proteins and their annotated locations for NP_001035814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks one exon in the 5' UTR and a second in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AJ250014, AK056226, AL050166, BI458962, BX642061, DA157717, DA785459, DA940312
    Consensus CDS
    CCDS42164.1
    UniProtKB/Swiss-Prot
    Q9NQC7
    UniProtKB/TrEMBL
    A0A024R6T1
    Related
    ENSP00000457576.1, ENST00000569418.5
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  2. NM_001042412.3NP_001035877.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    See identical proteins and their annotated locations for NP_001035877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' terminal exon, and lacks one exon in the 5' UTR and another in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/Swiss-Prot
    Q9NQC7
    UniProtKB/TrEMBL
    A0A024R6T1
    Related
    ENSP00000381574.2, ENST00000398568.6
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  3. NM_001378743.1NP_001365672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Related
    ENSP00000392025.3, ENST00000427738.8
    Conserved Domains (3) summary
    smart01052
    Location:472540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  4. NM_001378744.1NP_001365673.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Related
    ENSP00000454515.1, ENST00000564326.5
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  5. NM_001378745.1NP_001365674.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  6. NM_001378746.1NP_001365675.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  7. NM_001378747.1NP_001365676.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  8. NM_001378748.1NP_001365677.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  9. NM_001378749.1NP_001365678.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  10. NM_001378750.1NP_001365679.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  11. NM_001378751.1NP_001365680.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
  12. NM_001378752.1NP_001365681.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
  13. NM_001378753.1NP_001365682.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Related
    ENSP00000456488.2, ENST00000568704.2
  14. NM_001378754.1NP_001365683.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007728
  15. NM_001378755.1NP_001365684.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007728
  16. NM_015247.3NP_056062.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

    See identical proteins and their annotated locations for NP_056062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS45482.1
    UniProtKB/Swiss-Prot
    Q9NQC7
    Related
    ENSP00000308928.9, ENST00000311559.13
    Conserved Domains (3) summary
    smart01052
    Location:472540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RNA

  1. NR_166071.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007728

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    50742086..50801935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522911.2XP_011521213.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cl02553
    Location:590619
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  2. XM_017022980.1XP_016878469.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/Swiss-Prot
    Q9NQC7
    UniProtKB/TrEMBL
    A0A024R6T1
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  3. XM_017022978.1XP_016878467.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/Swiss-Prot
    Q9NQC7
    UniProtKB/TrEMBL
    A0A024R6T1
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RNA

  1. XR_933218.1 RNA Sequence

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