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CYLD CYLD lysine 63 deubiquitinase [ Homo sapiens (human) ]

Gene ID: 1540, updated on 19-Feb-2024

Summary

Official Symbol
CYLDprovided by HGNC
Official Full Name
CYLD lysine 63 deubiquitinaseprovided by HGNC
Primary source
HGNC:HGNC:2584
See related
Ensembl:ENSG00000083799 MIM:605018; AllianceGenome:HGNC:2584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; FTDALS8
Summary
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 13.0), lymph node (RPKM 10.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CYLD in Genome Data Viewer
Location:
16q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50742086..50801935)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (56539727..56599616)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50775997..50835846)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10821 Neighboring gene sorting nexin 20 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10825 Neighboring gene Sharpr-MPRA regulatory region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7490 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:50743936-50744141 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10826 Neighboring gene Sharpr-MPRA regulatory region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10827 Neighboring gene CYLD antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10828 Neighboring gene microRNA 3181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7492 Neighboring gene CYLD antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50843053-50844052 Neighboring gene long intergenic non-protein coding RNA 2168 Neighboring gene VISTA enhancer hs162 Neighboring gene long intergenic non-protein coding RNA 2128 Neighboring gene RNA, 5S ribosomal pseudogene 426

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-10)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-02-10)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CYLD by siRNA enhances HIV-1 infection in a single-cycle assay in HEK 293T cells, and the CYLD catalytic mutant C698A fails to reduce HIV-1 infection in 293T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 transcription increases upon CYLD knockdown in CD4+ T lymphocytes, leading to upregulation of HIV-1 Gag/p24 levels in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • HSPC057, FLJ20180, FLJ31664, FLJ78684, KIAA0849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked deubiquitinase activity EXP
Inferred from Experiment
more info
PubMed 
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables Met1-linked polyubiquitin deubiquitinase activity EXP
Inferred from Experiment
more info
PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-18-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein linear deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in ripoptosome assembly involved in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary tip ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD
Names
cylindromatosis (turban tumor syndrome)
deubiquitinating enzyme CYLD
probable ubiquitin carboxyl-terminal hydrolase CYLD
ubiquitin specific peptidase like 2
ubiquitin thioesterase CYLD
ubiquitin thiolesterase CYLD
ubiquitin-specific-processing protease CYLD
NP_001035814.1
NP_001035877.1
NP_001365672.1
NP_001365673.1
NP_001365674.1
NP_001365675.1
NP_001365676.1
NP_001365677.1
NP_001365678.1
NP_001365679.1
NP_001365680.1
NP_001365681.1
NP_001365682.1
NP_001365683.1
NP_001365684.1
NP_056062.1
XP_047289612.1
XP_047289614.1
XP_047289615.1
XP_047289616.1
XP_047289617.1
XP_047289618.1
XP_047289619.1
XP_047289620.1
XP_054235669.1
XP_054235670.1
XP_054235671.1
XP_054235672.1
XP_054235673.1
XP_054235674.1
XP_054235675.1
XP_054235676.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012061.1 RefSeqGene

    Range
    5001..64886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_491

mRNA and Protein(s)

  1. NM_001042355.2NP_001035814.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    See identical proteins and their annotated locations for NP_001035814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks one exon in the 5' UTR and a second in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AJ250014, AK056226, AL050166, BI458962, BX642061, DA157717, DA785459, DA940312
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000457576.1, ENST00000569418.5
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  2. NM_001042412.3NP_001035877.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    See identical proteins and their annotated locations for NP_001035877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' terminal exon, and lacks one exon in the 5' UTR and another in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000381574.2, ENST00000398568.6
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  3. NM_001378743.1NP_001365672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS45482.1
    UniProtKB/Swiss-Prot
    O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000392025.3, ENST00000427738.8
    Conserved Domains (3) summary
    smart01052
    Location:472540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  4. NM_001378744.1NP_001365673.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000454515.1, ENST00000564326.5
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  5. NM_001378745.1NP_001365674.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  6. NM_001378746.1NP_001365675.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  7. NM_001378747.1NP_001365676.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  8. NM_001378748.1NP_001365677.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  9. NM_001378749.1NP_001365678.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  10. NM_001378750.1NP_001365679.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS42164.1
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:469537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  11. NM_001378751.1NP_001365680.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:459527
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:580935
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304458
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  12. NM_001378752.1NP_001365681.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
    UniProtKB/TrEMBL
    A8KAB0
    Conserved Domains (3) summary
    smart01052
    Location:459527
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:580935
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304458
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  13. NM_001378753.1NP_001365682.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007728
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000456488.2, ENST00000568704.2
    Conserved Domains (3) summary
    smart01052
    Location:459527
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:580935
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304458
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  14. NM_001378754.1NP_001365683.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007728
    UniProtKB/TrEMBL
    B3KND1
    Conserved Domains (3) summary
    smart01052
    Location:247315
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:368723
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:82246
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  15. NM_001378755.1NP_001365684.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007728
    UniProtKB/TrEMBL
    B3KND1
    Conserved Domains (3) summary
    smart01052
    Location:247315
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:368723
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:82246
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  16. NM_015247.3NP_056062.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

    See identical proteins and their annotated locations for NP_056062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007728
    Consensus CDS
    CCDS45482.1
    UniProtKB/Swiss-Prot
    O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9
    UniProtKB/TrEMBL
    A8KAB0
    Related
    ENSP00000308928.9, ENST00000311559.13
    Conserved Domains (3) summary
    smart01052
    Location:472540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RNA

  1. NR_166071.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007728

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    50742086..50801935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433656.1XP_047289612.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  2. XM_047433661.1XP_047289617.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0
  3. XM_047433663.1XP_047289619.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

  4. XM_047433664.1XP_047289620.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

  5. XM_047433658.1XP_047289614.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  6. XM_047433662.1XP_047289618.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0
  7. XM_047433659.1XP_047289615.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  8. XM_047433660.1XP_047289616.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0

RNA

  1. XR_007064858.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    56539727..56599616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379694.1XP_054235669.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  2. XM_054379698.1XP_054235673.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0
  3. XM_054379700.1XP_054235675.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

  4. XM_054379701.1XP_054235676.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

  5. XM_054379695.1XP_054235670.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  6. XM_054379699.1XP_054235674.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0
  7. XM_054379696.1XP_054235671.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    A8KAB0
  8. XM_054379697.1XP_054235672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A8KAB0

RNA

  1. XR_008489063.1 RNA Sequence