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Cyld CYLD lysine 63 deubiquitinase [ Mus musculus (house mouse) ]

Gene ID: 74256, updated on 27-Feb-2024

Summary

Official Symbol
Cyldprovided by MGI
Official Full Name
CYLD lysine 63 deubiquitinaseprovided by MGI
Primary source
MGI:MGI:1921506
See related
Ensembl:ENSMUSG00000036712 AllianceGenome:MGI:1921506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik
Summary
This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 5.8), cortex adult (RPKM 5.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cyld in Genome Data Viewer
Location:
8 C3; 8 43.51 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89423506..89478574)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88696878..88751946)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22236 Neighboring gene STARR-seq mESC enhancer starr_22237 Neighboring gene STARR-positive B cell enhancer ABC_E2869 Neighboring gene sorting nexin 20 Neighboring gene STARR-positive B cell enhancer ABC_E3791 Neighboring gene STARR-positive B cell enhancer ABC_E6672 Neighboring gene nucleotide-binding oligomerization domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E108 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene ribosomal protein S6, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22238 Neighboring gene predicted gene, 42034

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables Met1-linked polyubiquitin deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-18-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein linear deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein linear deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with midbody ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD
Names
cylindromatosis (turban tumor syndrome)
deubiquitinating enzyme CYLD
ubiquitin thioesterase CYLD
ubiquitin thiolesterase CYLD
ubiquitin-specific-processing protease CYLD
NP_001121642.1
NP_001121643.1
NP_001263208.1
NP_775545.1
XP_006531477.1
XP_006531478.1
XP_006531479.1
XP_006531480.1
XP_006531481.1
XP_006531482.1
XP_006531483.1
XP_011246825.1
XP_011246826.1
XP_011246827.1
XP_030099667.1
XP_030099668.1
XP_030099669.1
XP_030099671.1
XP_030099672.1
XP_036010220.1
XP_036010221.1
XP_036010222.1
XP_036010223.1
XP_036010225.1
XP_036010226.1
XP_036010227.1
XP_036010228.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128170.2NP_001121642.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform a

    See identical proteins and their annotated locations for NP_001121642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region compared to variant 2. It encodes isoform a which is longer than isoform b.
    Source sequence(s)
    AC138025, AC156937, AK147204
    Consensus CDS
    CCDS52633.1
    UniProtKB/TrEMBL
    Z4YJJ5
    Related
    ENSMUSP00000147654.2, ENSMUST00000209532.2
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  2. NM_001128171.2NP_001121643.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

    See identical proteins and their annotated locations for NP_001121643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode isoform b.
    Source sequence(s)
    AC138025, AC156937
    Consensus CDS
    CCDS22513.1
    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Related
    ENSMUSP00000148037.2, ENSMUST00000211554.2
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  3. NM_001276279.1NP_001263208.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform c

    See identical proteins and their annotated locations for NP_001263208.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as short (s)-CYLD) differs in the 5' UTR and lacks several alternate exons in the coding region compared to variant 2. It encodes isoform c which is shorter than isoform b.
    Source sequence(s)
    AC138025, AC156937
    Consensus CDS
    CCDS85579.1
    UniProtKB/TrEMBL
    A0A1B0GSE5, Q3TJI3
    Related
    ENSMUSP00000147904.2, ENSMUST00000209206.2
    Conserved Domains (3) summary
    smart01052
    Location:127203
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:407762
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304375
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  4. NM_173369.3NP_775545.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

    See identical proteins and their annotated locations for NP_775545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform b. Both variants 2 and 4 encode isoform b.
    Source sequence(s)
    AC138025, AC156937
    Consensus CDS
    CCDS22513.1
    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Related
    ENSMUSP00000147426.2, ENSMUST00000209559.2
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    89423506..89478574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243811.1XP_030099671.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  2. XM_006531419.2XP_006531482.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

    UniProtKB/TrEMBL
    Q3TJI3
    Conserved Domains (3) summary
    smart01052
    Location:127203
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:410765
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307379
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  3. XM_006531420.3XP_006531483.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

    See identical proteins and their annotated locations for XP_006531483.1

    UniProtKB/TrEMBL
    A0A1B0GSE5, Q3TJI3
    Conserved Domains (3) summary
    smart01052
    Location:127203
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:407762
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304375
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  4. XM_036154328.1XP_036010221.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

    UniProtKB/TrEMBL
    A0A1B0GSE5, Q3TJI3
    Conserved Domains (3) summary
    smart01052
    Location:127203
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:407762
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304375
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  5. XM_006531416.5XP_006531479.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_006531479.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  6. XM_036154330.1XP_036010223.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

    Conserved Domains (3) summary
    smart01052
    Location:249317
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:370725
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:85248
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  7. XM_036154335.1XP_036010228.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X7

    Conserved Domains (2) summary
    smart01052
    Location:1064
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:185540
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  8. XM_030243809.1XP_030099669.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  9. XM_036154333.1XP_036010226.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

    Conserved Domains (3) summary
    smart01052
    Location:246314
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:367722
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:82245
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  10. XM_030243807.1XP_030099667.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  11. XM_006531417.4XP_006531480.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_006531480.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  12. XM_036154329.1XP_036010222.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

    UniProtKB/TrEMBL
    A0A1B0GSE5, Q3TJI3
    Conserved Domains (3) summary
    smart01052
    Location:127203
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:407762
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304375
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  13. XM_011248525.4XP_011246827.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_011246827.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  14. XM_006531414.3XP_006531477.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_006531477.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  15. XM_030243812.2XP_030099672.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  16. XM_030243808.1XP_030099668.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  17. XM_006531415.2XP_006531478.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_006531478.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  18. XM_011248524.3XP_011246826.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_011246826.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  19. XM_036154332.1XP_036010225.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

    Conserved Domains (3) summary
    smart01052
    Location:249317
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:370725
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:85248
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  20. XM_036154334.1XP_036010227.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

    Conserved Domains (3) summary
    smart01052
    Location:246314
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:367722
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:82245
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  21. XM_011248523.4XP_011246825.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_011246825.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  22. XM_006531418.4XP_006531481.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    See identical proteins and their annotated locations for XP_006531481.1

    UniProtKB/TrEMBL
    Z4YJJ5
    Conserved Domains (3) summary
    smart01052
    Location:471539
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:592947
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307470
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
  23. XM_036154327.1XP_036010220.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/Swiss-Prot
    Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0
    UniProtKB/TrEMBL
    Q3V028
    Conserved Domains (3) summary
    smart01052
    Location:468536
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:589944
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304467
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001128169.1: Suppressed sequence

    Description
    NM_001128169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.