Format

Send to:

Choose Destination

CYBB cytochrome b-245 beta chain [ Homo sapiens (human) ]

Gene ID: 1536, updated on 21-Jan-2020

Summary

Official Symbol
CYBBprovided by HGNC
Official Full Name
cytochrome b-245 beta chainprovided by HGNC
Primary source
HGNC:HGNC:2578
See related
Ensembl:ENSG00000165168 MIM:300481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGD; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX
Summary
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 106.7), bone marrow (RPKM 63.5) and 15 other tissues See more
Orthologs

Genomic context

See CYBB in Genome Data Viewer
Location:
Xp21.1-p11.4
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (37780059..37813461)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37639266..37672718)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LanC like 3 Neighboring gene X-linked Kx blood group Neighboring gene dynein light chain Tctex-type 3 Neighboring gene RNA, U6 small nuclear 49, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cytochrome b-245, beta polypeptide (CYBB) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Knockdown of NOX2 and NOX4 by siRNA abrogates HIV-1 gp120-induced reactive oxygen species (ROS), suggesting that NOX2 and NOX4 are involved in ROS production through CYP2E1 in astrocytes PubMed
env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
Nef nef NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells PubMed
Tat tat HIV-1 Tat C downregulates the expression of miR-17 to increase the expression of NOX2 and NOX4; overexpression of miR-17 inhibits NOX2 and NOX4 expression in human microglial cells PubMed
tat HIV-1 Tat C upregulates NOX2 and NOX4 expression and increases ROS production in human brain cells PubMed
tat Knocking down Nox2 by siRNA blocks HIV-1 Tat-induced reactive oxygen species (ROS) production, increase of NADPH oxidase activity, and Rac1 activation PubMed
tat HIV-1 Tat downregulates the expression of cytochrome b-245, beta polypeptide (CYBB; NOX2) in human primary T cells PubMed
tat Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 PubMed
tat Knocking down oxidase Nox2 blocks Tat-induced cytoskeletal rearrangement PubMed
tat HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase (NOX2) inhibitor PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed
tat Nox2 is involved in HIV-1 Tat-induced NADPH oxidase p65 and IKK phosphorylation PubMed
capsid gag HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
heme binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide-generating NADPH oxidase activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
cell redox homeostasis TAS
Traceable Author Statement
more info
 
cellular response to L-glutamine IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hypoxia-inducible factor-1alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
respiratory burst IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory burst TAS
Traceable Author Statement
more info
PubMed 
response to aldosterone IEA
Inferred from Electronic Annotation
more info
 
response to angiotensin IEA
Inferred from Electronic Annotation
more info
 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
superoxide anion generation TAS
Traceable Author Statement
more info
PubMed 
superoxide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
superoxide metabolic process TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
NADPH oxidase complex TAS
Traceable Author Statement
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
perinuclear endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytochrome b-245 heavy chain
Names
CGD91-phox
NADPH oxidase 2
cytochrome b(558) subunit beta
cytochrome b-245 beta polypeptide
cytochrome b558 subunit beta
heme-binding membrane glycoprotein gp91phox
neutrophil cytochrome b 91 kDa polypeptide
p22 phagocyte B-cytochrome
superoxide-generating NADPH oxidase heavy chain subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009065.1 RefSeqGene

    Range
    5001..38445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_53

mRNA and Protein(s)

  1. NM_000397.4NP_000388.2  cytochrome b-245 heavy chain

    See identical proteins and their annotated locations for NP_000388.2

    Status: REVIEWED

    Source sequence(s)
    BC032720
    Consensus CDS
    CCDS14242.1
    UniProtKB/Swiss-Prot
    P04839
    UniProtKB/TrEMBL
    A0A0S2Z3S6
    Related
    ENSP00000367851.4, ENST00000378588.4
    Conserved Domains (3) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:66219
    Ferric_reduct; Ferric reductase like transmembrane component
    cl26813
    Location:165423
    PLN02844; oxidoreductase/ferric-chelate reductase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    37780059..37813461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center