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Cybb cytochrome b-245, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13058, updated on 17-Jan-2022

Summary

Official Symbol
Cybbprovided by MGI
Official Full Name
cytochrome b-245, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88574
See related
Ensembl:ENSMUSG00000015340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
Summary
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Expression
Biased expression in liver E18 (RPKM 7.0), spleen adult (RPKM 4.7) and 13 other tissues See more
Orthologs
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Genomic context

See Cybb in Genome Data Viewer
Location:
X; X A1.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9301493..9354005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (9435252..9487766, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (9012378..9046450, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6829 Neighboring gene H2A histone family member L1K Neighboring gene predicted gene, 33784 Neighboring gene predicted gene, 25728 Neighboring gene H2A histone family member L1O

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables superoxide-generating NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to superoxide-generating NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory burst ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome b-245 heavy chain
Names
NADPH oxidase 2
cytochrome b558 subunit beta
heme-binding membrane glycoprotein gp91phox
neutrophil cytochrome b 91 kDa polypeptide
p22 phagocyte B-cytochrome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007807.5NP_031833.3  cytochrome b-245 heavy chain

    See identical proteins and their annotated locations for NP_031833.3

    Status: REVIEWED

    Source sequence(s)
    AK152257, AL671864, BY194282
    Consensus CDS
    CCDS30010.1
    UniProtKB/Swiss-Prot
    Q61093
    UniProtKB/TrEMBL
    Q3U6G0
    Related
    ENSMUSP00000015484.4, ENSMUST00000015484.10
    Conserved Domains (3) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    PLN02844
    Location:165423
    PLN02844; oxidoreductase/ferric-chelate reductase
    pfam01794
    Location:66219
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    9301493..9354005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527565.4XP_006527628.1  cytochrome b-245 heavy chain isoform X1

    See identical proteins and their annotated locations for XP_006527628.1

    UniProtKB/Swiss-Prot
    Q61093
    UniProtKB/TrEMBL
    Q3U6G0
    Conserved Domains (3) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    PLN02844
    Location:165423
    PLN02844; oxidoreductase/ferric-chelate reductase
    pfam01794
    Location:66219
    Ferric_reduct; Ferric reductase like transmembrane component
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