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Cybb cytochrome b-245, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13058, updated on 27-Jun-2017
Official Symbol
Cybbprovided by MGI
Official Full Name
cytochrome b-245, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88574
See related
Ensembl:ENSMUSG00000015340 Vega:OTTMUSG00000016894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox
Summary
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Orthologs
Location:
X; X A1.1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (9435252..9487766, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (9012378..9046450, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6829 Neighboring gene H2A histone family member L1K Neighboring gene predicted gene, 33784 Neighboring gene H2A histone family member L1O Neighboring gene dynein light chain Tctex-type 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to electron carrier activity ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to superoxide-generating NADPH oxidase activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
respiratory burst ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cytochrome b-245 heavy chain
Names
NADPH oxidase 2
cytochrome b558 subunit beta
heme-binding membrane glycoprotein gp91phox
neutrophil cytochrome b 91 kDa polypeptide
p22 phagocyte B-cytochrome

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007807.5NP_031833.3  cytochrome b-245 heavy chain

    See identical proteins and their annotated locations for NP_031833.3

    Status: REVIEWED

    Source sequence(s)
    AK152257, AL671864, BY194282
    Consensus CDS
    CCDS30010.1
    UniProtKB/Swiss-Prot
    Q61093
    UniProtKB/TrEMBL
    Q3U6G0
    Related
    ENSMUSP00000015484.3, OTTMUSP00000018354, ENSMUST00000015484.9, OTTMUST00000040996
    Conserved Domains (2) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:65219
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    9435252..9487766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527565.3XP_006527628.1  cytochrome b-245 heavy chain isoform X1

    See identical proteins and their annotated locations for XP_006527628.1

    UniProtKB/Swiss-Prot
    Q61093
    UniProtKB/TrEMBL
    Q3U6G0
    Conserved Domains (2) summary
    cd06186
    Location:297570
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    pfam01794
    Location:65219
    Ferric_reduct; Ferric reductase like transmembrane component
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