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Hk1 hexokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 15275, updated on 5-Jan-2023

Summary

Official Symbol
Hk1provided by MGI
Official Full Name
hexokinase 1provided by MGI
Primary source
MGI:MGI:96103
See related
Ensembl:ENSMUSG00000037012 AllianceGenome:MGI:96103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dea; Hk-1; Hk1-s; mHk1-s
Summary
Enables glucokinase activity and peptidoglycan binding activity. Involved in carbohydrate phosphorylation; positive regulation of cytokine production involved in immune response; and positive regulation of interleukin-1 beta production. Located in several cellular components, including membrane raft; mitochondrion; and sperm principal piece. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 245.2), cortex adult (RPKM 43.6) and 17 other tissues See more
Orthologs
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Genomic context

See Hk1 in Genome Data Viewer
Location:
10 B4; 10 32.37 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62104634..62215699, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62268855..62379920, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene microRNA 7662 Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1, opposite strand Neighboring gene hexokinase domain containing 1 Neighboring gene predicted gene, 30322 Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glucose binding ISO
Inferred from Sequence Orthology
more info
 
enables hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables hexokinase activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mannokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycolytic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in mannose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hexokinase-1
Names
HK I
downeast anemia
hexokinase type I
hexokinase, tumor isozyme
NP_001139572.1
NP_034568.2
XP_006513305.1
XP_006513306.1
XP_006513307.1
XP_006513308.1
XP_006513309.1
XP_006513310.1
XP_030100764.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146100.1NP_001139572.1  hexokinase-1 isoform HK1

    See identical proteins and their annotated locations for NP_001139572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the ubiquitously expressed transcript and encodes isoform HK1. Its 5' end includes an exon that is unique to this transcript and encodes a distinct N-terminus containing the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.
    Source sequence(s)
    AK161466, BC072628
    Consensus CDS
    CCDS48577.1
    UniProtKB/TrEMBL
    Q3TTB4, Q6GQU1
    Related
    ENSMUSP00000097282.5, ENSMUST00000099691.11
    Conserved Domains (3) summary
    PTZ00107
    Location:462907
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:469667
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673907
    Hexokinase_2; Hexokinase
  2. NM_010438.3NP_034568.2  hexokinase-1 isoform HK1-sb

    See identical proteins and their annotated locations for NP_034568.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has four novel exons in the 5' end and one novel in-frame exon in the 3' coding region , compared to variant 1. These differences result in a protein (isoform HK1-sb) with a longer and distinct N-terminus and a longer C-terminus, compared to isoform HK1. This transcript is expressed exclusively in the testis and its protein lacks the porin binding domain that mediates association with the mitochondrial membrane in isoform HK1.
    Source sequence(s)
    AC145297, AK161466, BC072628, CV308179, EU430526
    Consensus CDS
    CCDS48578.1
    UniProtKB/TrEMBL
    B4YB29, Q3TTB4, Q6GQU1
    Related
    ENSMUSP00000111946.3, ENSMUST00000116238.9
    Conserved Domains (3) summary
    PTZ00107
    Location:489934
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:496694
    Hexokinase_1; Hexokinase
    pfam03727
    Location:700934
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62104634..62215699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513245.4XP_006513308.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513308.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:23464
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1
    pfam03727
    Location:677911
    Hexokinase_2
  2. XM_006513244.4XP_006513307.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513307.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:23464
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1
    pfam03727
    Location:677911
    Hexokinase_2
  3. XM_006513243.4XP_006513306.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513306.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:23464
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1
    pfam03727
    Location:677911
    Hexokinase_2
  4. XM_006513242.2XP_006513305.1  hexokinase-1 isoform X1

    See identical proteins and their annotated locations for XP_006513305.1

    UniProtKB/Swiss-Prot
    P17710, Q64479
    Conserved Domains (3) summary
    PTZ00107
    Location:75516
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:525723
    Hexokinase_1
    pfam03727
    Location:729963
    Hexokinase_2
  5. XM_030244904.1XP_030100764.1  hexokinase-1 isoform X5

    Conserved Domains (3) summary
    PTZ00107
    Location:75539
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:548746
    Hexokinase_1
    pfam03727
    Location:752986
    Hexokinase_2
  6. XM_006513246.4XP_006513309.1  hexokinase-1 isoform X3

    See identical proteins and their annotated locations for XP_006513309.1

    UniProtKB/TrEMBL
    G3UVV4
    Related
    ENSMUSP00000118601.2, ENSMUST00000130422.8
    Conserved Domains (3) summary
    PTZ00107
    Location:18459
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:468666
    Hexokinase_1
    pfam03727
    Location:672906
    Hexokinase_2
  7. XM_006513247.2XP_006513310.1  hexokinase-1 isoform X4

    See identical proteins and their annotated locations for XP_006513310.1

    Conserved Domains (3) summary
    PTZ00107
    Location:8446
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:455653
    Hexokinase_1
    pfam03727
    Location:659893
    Hexokinase_2