Format

Send to:

Choose Destination

Hk1 hexokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 15275, updated on 5-Aug-2018

Summary

Official Symbol
Hk1provided by MGI
Official Full Name
hexokinase 1provided by MGI
Primary source
MGI:MGI:96103
See related
Ensembl:ENSMUSG00000037012 Vega:OTTMUSG00000034151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dea; Hk-1; Hk1-s; mHk1-s; BB404130
Expression
Broad expression in testis adult (RPKM 245.2), cortex adult (RPKM 43.6) and 17 other tissues See more
Orthologs

Genomic context

See Hk1 in Genome Data Viewer
Location:
10 B4; 10 32.37 cM
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (62268855..62379916, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (61731603..61842656, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene tetraspanin 15 Neighboring gene microRNA 7662 Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1, opposite strand Neighboring gene predicted gene, 40675 Neighboring gene hexokinase domain containing 1 Neighboring gene predicted gene, 30322 Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
glucose binding ISO
Inferred from Sequence Orthology
more info
 
hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
hexokinase activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
canonical glycolysis IC
Inferred by Curator
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process ISO
Inferred from Sequence Orthology
more info
 
glycolytic process TAS
Traceable Author Statement
more info
PubMed 
maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
response to ischemia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola ISO
Inferred from Sequence Orthology
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hexokinase-1
Names
HK I
downeast anemia
hexokinase type I
hexokinase, tumor isozyme
NP_001139572.1
NP_034568.2
XP_006513305.1
XP_006513306.1
XP_006513307.1
XP_006513308.1
XP_006513309.1
XP_006513310.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146100.1NP_001139572.1  hexokinase-1 isoform HK1

    See identical proteins and their annotated locations for NP_001139572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the ubiquitously expressed transcript and encodes isoform HK1. Its 5' end includes an exon that is unique to this transcript and encodes a distinct N-terminus containing the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.
    Source sequence(s)
    AK161466, BC072628
    Consensus CDS
    CCDS48577.1
    UniProtKB/TrEMBL
    Q3TTB4, Q6GQU1
    Related
    ENSMUSP00000097282.4, OTTMUSP00000046862, ENSMUST00000099691.10, OTTMUST00000086517
    Conserved Domains (3) summary
    PTZ00107
    Location:462907
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:469667
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673907
    Hexokinase_2; Hexokinase
  2. NM_010438.3NP_034568.2  hexokinase-1 isoform HK1-sb

    See identical proteins and their annotated locations for NP_034568.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has four novel exons in the 5' end and one novel in-frame exon in the 3' coding region , compared to variant 1. These differences result in a protein (isoform HK1-sb) with a longer and distinct N-terminus and a longer C-terminus, compared to isoform HK1. This transcript is expressed exclusively in the testis and its protein lacks the porin binding domain that mediates association with the mitochondrial membrane in isoform HK1.
    Source sequence(s)
    AC145297, AK161466, BC072628, CV308179, EU430526
    Consensus CDS
    CCDS48578.1
    UniProtKB/TrEMBL
    B4YB29, Q3TTB4, Q6GQU1
    Related
    ENSMUSP00000111946.2, OTTMUSP00000046850, ENSMUST00000116238.8, OTTMUST00000086504
    Conserved Domains (3) summary
    PTZ00107
    Location:489934
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:496694
    Hexokinase_1; Hexokinase
    pfam03727
    Location:700934
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    62268855..62379916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513245.3XP_006513308.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513308.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:466911
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1; Hexokinase
    pfam03727
    Location:677911
    Hexokinase_2; Hexokinase
  2. XM_006513244.3XP_006513307.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513307.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:466911
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1; Hexokinase
    pfam03727
    Location:677911
    Hexokinase_2; Hexokinase
  3. XM_006513243.3XP_006513306.1  hexokinase-1 isoform X2

    See identical proteins and their annotated locations for XP_006513306.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:466911
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:473671
    Hexokinase_1; Hexokinase
    pfam03727
    Location:677911
    Hexokinase_2; Hexokinase
  4. XM_006513242.1XP_006513305.1  hexokinase-1 isoform X1

    See identical proteins and their annotated locations for XP_006513305.1

    UniProtKB/Swiss-Prot
    P17710
    Conserved Domains (3) summary
    PTZ00107
    Location:518963
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:525723
    Hexokinase_1; Hexokinase
    pfam03727
    Location:729963
    Hexokinase_2; Hexokinase
  5. XM_006513246.3XP_006513309.1  hexokinase-1 isoform X3

    See identical proteins and their annotated locations for XP_006513309.1

    UniProtKB/TrEMBL
    G3UVV4
    Related
    ENSMUSP00000118601.1, OTTMUSP00000046865, ENSMUST00000130422.7, OTTMUST00000086526
    Conserved Domains (3) summary
    PTZ00107
    Location:18459
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:468666
    Hexokinase_1; Hexokinase
    pfam03727
    Location:672906
    Hexokinase_2; Hexokinase
  6. XM_006513247.1XP_006513310.1  hexokinase-1 isoform X4

    See identical proteins and their annotated locations for XP_006513310.1

    Conserved Domains (3) summary
    PTZ00107
    Location:448893
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:455653
    Hexokinase_1; Hexokinase
    pfam03727
    Location:659893
    Hexokinase_2; Hexokinase
Support Center