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Conserved domains on  [gi|568966727|ref|XP_006513309|]
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hexokinase-1 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
672-906 4.72e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


:

Pssm-ID: 427467  Cd Length: 238  Bit Score: 332.92  E-value: 4.72e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  672 EIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMY 748
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  749 LGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDR-LALLQVRAILQQ-LGLNS-TCDDSILVKTVCGVV 825
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  826 SKRAAQLCGAGMAAVVEKIRENRgldhlnVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAAL 902
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELlgpELEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 568966727  903 ITAV 906
Cdd:pfam03727 235 IAAV 238
PLN02914 super family cl42853
hexokinase
18-459 7.07e-108

hexokinase


The actual alignment was detected with superfamily member PTZ00107:

Pssm-ID: 456198 [Multi-domain]  Cd Length: 464  Bit Score: 341.27  E-value: 7.07e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  18 EARIDKYLYAMRLSDEILIDILTRFKKEMKNGL-SRDYNPTA------SVKMLPTFVRSIPDGSEKGDFIALDLGGSSFR 90
Cdd:PTZ00107   8 RVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAIDFGGTNFR 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  91 ILRVQVNH----EKSQN-VSMESEVYDTPENIV--HGSGSQLFDHVAECLGDFMEKRKIKD---KKLPVGFTFSFPCRQS 160
Cdd:PTZ00107  88 AVRVSLRGggkmERTQSkFSLPKSALLGEKGLLdkKATATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGFTFSFPCTQL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 161 KIDEAVLITWTKRFKAS-----GVEGADVVKLLNKAIKkRGDYDANIVAVVNDTVGTMMTCGYDDQ----QCEVGLIIGT 231
Cdd:PTZ00107 168 SVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFK-RNNVPANVVAVLNDTVGTLISCAYQKPkntpPCQVGVIIGT 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 232 GTNACYMEelrHIDLVEGDEGRMcINTEWGAFgdDGSLEdiRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 311
Cdd:PTZ00107 247 GSNACYFE---PEVSAYGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAYLGEISRRLIVH 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 312 MAKESLLfegritPELLTRGKFTTSDVAAIETDK-EGVQNAKEILTRL-GVEPSHDDCVSVQHVCTIVSFRSANLVAATL 389
Cdd:PTZ00107 319 LLQLKAP------PKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVRGRAAQLAAAFI 392
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568966727 390 GAILNRLRdnkgTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD--SDVRFLLSESGSGKGAAMVTAVA 459
Cdd:PTZ00107 393 AAPAKKTR----TVQGKATVAIDGSVYVKNPWFRRLLQEYINSILGPdaGNVVFYLADDGSGKGAAIIAAMV 460
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
468-666 3.54e-95

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


:

Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 297.50  E-value: 3.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  468 QIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSraTVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIrsG 547
Cdd:pfam00349   1 ALEELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSS--SLKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--G 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  548 KKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIK---GPRMPLGFTFSFPCKQTSLDCGILITWTKGFKA 624
Cdd:pfam00349  77 GDGKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDSGTLIRWTKGFDI 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568966727  625 TDCVGHDVATLLRDAVKRREEfDLDVVAVVNDTVGTMMTCAY 666
Cdd:pfam00349 157 PGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
 
Name Accession Description Interval E-value
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
672-906 4.72e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 332.92  E-value: 4.72e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  672 EIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMY 748
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  749 LGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDR-LALLQVRAILQQ-LGLNS-TCDDSILVKTVCGVV 825
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  826 SKRAAQLCGAGMAAVVEKIRENRgldhlnVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAAL 902
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELlgpELEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 568966727  903 ITAV 906
Cdd:pfam03727 235 IAAV 238
PTZ00107 PTZ00107
hexokinase; Provisional
18-459 7.07e-108

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 341.27  E-value: 7.07e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  18 EARIDKYLYAMRLSDEILIDILTRFKKEMKNGL-SRDYNPTA------SVKMLPTFVRSIPDGSEKGDFIALDLGGSSFR 90
Cdd:PTZ00107   8 RVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAIDFGGTNFR 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  91 ILRVQVNH----EKSQN-VSMESEVYDTPENIV--HGSGSQLFDHVAECLGDFMEKRKIKD---KKLPVGFTFSFPCRQS 160
Cdd:PTZ00107  88 AVRVSLRGggkmERTQSkFSLPKSALLGEKGLLdkKATATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGFTFSFPCTQL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 161 KIDEAVLITWTKRFKAS-----GVEGADVVKLLNKAIKkRGDYDANIVAVVNDTVGTMMTCGYDDQ----QCEVGLIIGT 231
Cdd:PTZ00107 168 SVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFK-RNNVPANVVAVLNDTVGTLISCAYQKPkntpPCQVGVIIGT 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 232 GTNACYMEelrHIDLVEGDEGRMcINTEWGAFgdDGSLEdiRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 311
Cdd:PTZ00107 247 GSNACYFE---PEVSAYGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAYLGEISRRLIVH 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 312 MAKESLLfegritPELLTRGKFTTSDVAAIETDK-EGVQNAKEILTRL-GVEPSHDDCVSVQHVCTIVSFRSANLVAATL 389
Cdd:PTZ00107 319 LLQLKAP------PKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVRGRAAQLAAAFI 392
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568966727 390 GAILNRLRdnkgTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD--SDVRFLLSESGSGKGAAMVTAVA 459
Cdd:PTZ00107 393 AAPAKKTR----TVQGKATVAIDGSVYVKNPWFRRLLQEYINSILGPdaGNVVFYLADDGSGKGAAIIAAMV 460
PTZ00107 PTZ00107
hexokinase; Provisional
461-906 2.69e-107

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 339.73  E-value: 2.69e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 461 RLAEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGL---RKETN----SRATVKMLPSYVRSIPDGTEHGDFLALDLG 533
Cdd:PTZ00107   3 RYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeahRRHRNlwipNECSFKMLDSCVYNLPTGKEKGVYYAIDFG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 534 GTNFRVLLVKIRSGKKrtVEMHNKIYSIPLEIMQG---------TGDELFDHIVSCISDFLDYMGIK---GPRMPLGFTF 601
Cdd:PTZ00107  83 GTNFRAVRVSLRGGGK--MERTQSKFSLPKSALLGekglldkkaTATDLFDHIAKSIKKMMEENGDPedlNKPVPVGFTF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 602 SFPCKQTSLDCGILITWTKGFK----ATDCV-GHDVATLLRDAVKRrEEFDLDVVAVVNDTVGTMMTCAYEE----PSCE 672
Cdd:PTZ00107 161 SFPCTQLSVNNAILIDWTKGFEtgraTNDPVeGKDVGELLNDAFKR-NNVPANVVAVLNDTVGTLISCAYQKpkntPPCQ 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 673 IGLIVGTGSNACYME-EMKNVemveGNQGQMcINMEWGAFgdngCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGE 751
Cdd:PTZ00107 240 VGVIIGTGSNACYFEpEVSAY----GYAGTP-INMECGNF----DSKLPITPYDLEMDWYTPNRGRQQFEKMISGAYLGE 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 752 IVRNILIDftkkgfLFRGQISEPLKTRGIFETKFLSQIESDRLALLQ-VRAILQQL-GLNSTCDDSILVKTVCGVVSKRA 829
Cdd:PTZ00107 311 ISRRLIVH------LLQLKAPPKMWQSGSFESEDASMILNDQSPDLQfSRQVIKEAwDVDLTDEDLYTIRKICELVRGRA 384
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568966727 830 AQLCGAGMAAVVEKIRENRGLdhlnVTVGVDGTLYKLHPHFSRIMHQTVKE-LSPK-CTVSFLLSEDGSGKGAALITAV 906
Cdd:PTZ00107 385 AQLAAAFIAAPAKKTRTVQGK----ATVAIDGSVYVKNPWFRRLLQEYINSiLGPDaGNVVFYLADDGSGKGAAIIAAM 459
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
224-458 4.74e-102

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 317.13  E-value: 4.74e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  224 EVGLIIGTGTNACYMEELRHIDLVEGD---EGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMY 300
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGKlpkSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  301 MGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDK-EGVQNAKEILTR-LGVE-PSHDDCVSVQHVCTIV 377
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIEtCTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  378 SFRSANLVAATLGAILNRLRDNkgtprlRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDS---DVRFLLSESGSGKGAAM 454
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGG------RVTVGVDGSVYEKYPGFRERLQEALRELLGPEledKVVLVLAEDGSGVGAAL 234

                  ....
gi 568966727  455 VTAV 458
Cdd:pfam03727 235 IAAV 238
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
467-906 2.45e-99

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 318.58  E-value: 2.45e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 467 RQIEETLSHFRLSKQALMEVKKKLRSEMEMGLrkETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIrs 546
Cdd:COG5026   19 QAVEELVESFTVPTEDLREVVKAFIEELEKGL--QPKSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVL-- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 547 GKKRTVEMHNKIYSIPLEIMQG-TGDELFDHIVSCISDFLD--YMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFK 623
Cdd:COG5026   95 GGDGTFDIEQSKSFLPVECRDSeSRDELFGFIADRLAAFIKeqHPSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 624 ATDCVGHDVATLLRDAVKRREeFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQ---- 699
Cdd:COG5026  175 IPEVIGTDVVRLLQEALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDDlpet 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 700 GQMCINMEWGAFgDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 779
Cdd:COG5026  254 GPMLINCEWGSF-DNELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPF 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 780 IFETKFLSQIESDR-LALLQVRAILQQ-LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDhlnvtV 857
Cdd:COG5026  333 ALSTSVLSRIEEDPfENLRNTLTTFLNdFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYKAYH-----V 407
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568966727 858 GVDGTLYKLHPHFSRIMHQTVKEL--SPKCTVSFLLSEDGSGKGAALITAV 906
Cdd:COG5026  408 GADGSVIERYPGFRSMLREALKALlgEEGEKIKIKPAEDGSGLGAALCALL 458
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
468-666 3.54e-95

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 297.50  E-value: 3.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  468 QIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSraTVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIrsG 547
Cdd:pfam00349   1 ALEELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSS--SLKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--G 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  548 KKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIK---GPRMPLGFTFSFPCKQTSLDCGILITWTKGFKA 624
Cdd:pfam00349  77 GDGKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDSGTLIRWTKGFDI 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568966727  625 TDCVGHDVATLLRDAVKRREEfDLDVVAVVNDTVGTMMTCAY 666
Cdd:pfam00349 157 PGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
33-459 1.02e-83

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 276.98  E-value: 1.02e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  33 EILIDILTRFKKEMKNGLSRdyNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSqnVSMESEVYD 112
Cdd:COG5026   33 EDLREVVKAFIEELEKGLQP--KSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVLGGDGT--FDIEQSKSF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 113 TPENIVHG-SGSQLFDHVAECLGDFMEKR--KIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLN 189
Cdd:COG5026  109 LPVECRDSeSRDELFGFIADRLAAFIKEQhpSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFDIPEVIGTDVVRLLQ 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 190 KAIKKRGdYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGD----EGRMCINTEWGAFgD 265
Cdd:COG5026  189 EALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDdlpeTGPMLINCEWGSF-D 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 266 DGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDK 345
Cdd:COG5026  267 NELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPFALSTSVLSRIEEDP 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 346 -EGVQNAKEILTR-LGVEPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKgtprlRTTVGVDGSLYKMHPQYS 423
Cdd:COG5026  347 fENLRNTLTTFLNdFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYK-----AYHVGADGSVIERYPGFR 421
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 568966727 424 RRFHKTLRRLVPDSDVRFLL--SESGSGKGAAMVTAVA 459
Cdd:COG5026  422 SMLREALKALLGEEGEKIKIkpAEDGSGLGAALCALLA 459
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
80-261 1.51e-13

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 69.93  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  80 IALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVhgsGSQLFDHVAECLGDFMEKRKikDKKLPVGFTFSFPCRQ 159
Cdd:cd00012    1 LGIDIGSTSTKAGVADLDGEILPEEIVPTPVGRPGAVTD---LDELEEALRELLKEALRQLK--SEIDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 160 SKIDEAVLITWtkrfkasgvegadvvkLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY--DDQQCEVGLIIGTG-TNAC 236
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGtTGIA 139
                        170       180
                 ....*....|....*....|....*
gi 568966727 237 YMEElrhidlvegDEGRMCINTEWG 261
Cdd:cd00012  140 IVED---------GKGGVGAAGELG 155
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
528-728 4.44e-12

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 65.69  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 528 LALDLGGTNFRVLLVKIRsgkKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKgpRMPLGFTFSFPCKQ 607
Cdd:cd00012    1 LGIDIGSTSTKAGVADLD---GEILPEEIVPTPVGRPGAVTDLDELEEALRELLKEALRQLKSE--IDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 608 TSLDCGILITWtkgfkatdcvghdvatLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAY--EEPSCEIGLIVGTGS-NAC 684
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGTtGIA 139
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568966727 685 YMEEMKnvemvegnqGQMCINMEWG-AFGDNGCLDDIRTDFDKVV 728
Cdd:cd00012  140 IVEDGK---------GGVGAAGELGiAEALAAVLNLLDGLPDAVV 175
 
Name Accession Description Interval E-value
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
672-906 4.72e-108

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 332.92  E-value: 4.72e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  672 EIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMY 748
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGklpKSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  749 LGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDR-LALLQVRAILQQ-LGLNS-TCDDSILVKTVCGVV 825
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIETcTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  826 SKRAAQLCGAGMAAVVEKIRENRgldhlnVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAAL 902
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGGR------VTVGVDGSVYEKYPGFRERLQEALRELlgpELEDKVVLVLAEDGSGVGAAL 234

                  ....
gi 568966727  903 ITAV 906
Cdd:pfam03727 235 IAAV 238
PTZ00107 PTZ00107
hexokinase; Provisional
18-459 7.07e-108

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 341.27  E-value: 7.07e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  18 EARIDKYLYAMRLSDEILIDILTRFKKEMKNGL-SRDYNPTA------SVKMLPTFVRSIPDGSEKGDFIALDLGGSSFR 90
Cdd:PTZ00107   8 RVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeAHRRHRNLwipnecSFKMLDSCVYNLPTGKEKGVYYAIDFGGTNFR 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  91 ILRVQVNH----EKSQN-VSMESEVYDTPENIV--HGSGSQLFDHVAECLGDFMEKRKIKD---KKLPVGFTFSFPCRQS 160
Cdd:PTZ00107  88 AVRVSLRGggkmERTQSkFSLPKSALLGEKGLLdkKATATDLFDHIAKSIKKMMEENGDPEdlnKPVPVGFTFSFPCTQL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 161 KIDEAVLITWTKRFKAS-----GVEGADVVKLLNKAIKkRGDYDANIVAVVNDTVGTMMTCGYDDQ----QCEVGLIIGT 231
Cdd:PTZ00107 168 SVNNAILIDWTKGFETGratndPVEGKDVGELLNDAFK-RNNVPANVVAVLNDTVGTLISCAYQKPkntpPCQVGVIIGT 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 232 GTNACYMEelrHIDLVEGDEGRMcINTEWGAFgdDGSLEdiRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 311
Cdd:PTZ00107 247 GSNACYFE---PEVSAYGYAGTP-INMECGNF--DSKLP--ITPYDLEMDWYTPNRGRQQFEKMISGAYLGEISRRLIVH 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 312 MAKESLLfegritPELLTRGKFTTSDVAAIETDK-EGVQNAKEILTRL-GVEPSHDDCVSVQHVCTIVSFRSANLVAATL 389
Cdd:PTZ00107 319 LLQLKAP------PKMWQSGSFESEDASMILNDQsPDLQFSRQVIKEAwDVDLTDEDLYTIRKICELVRGRAAQLAAAFI 392
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568966727 390 GAILNRLRdnkgTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD--SDVRFLLSESGSGKGAAMVTAVA 459
Cdd:PTZ00107 393 AAPAKKTR----TVQGKATVAIDGSVYVKNPWFRRLLQEYINSILGPdaGNVVFYLADDGSGKGAAIIAAMV 460
PTZ00107 PTZ00107
hexokinase; Provisional
461-906 2.69e-107

hexokinase; Provisional


Pssm-ID: 240270 [Multi-domain]  Cd Length: 464  Bit Score: 339.73  E-value: 2.69e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 461 RLAEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGL---RKETN----SRATVKMLPSYVRSIPDGTEHGDFLALDLG 533
Cdd:PTZ00107   3 RYIKQRVRLASLVNQFTMSKEKLKELVDYFLYELVEGLeahRRHRNlwipNECSFKMLDSCVYNLPTGKEKGVYYAIDFG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 534 GTNFRVLLVKIRSGKKrtVEMHNKIYSIPLEIMQG---------TGDELFDHIVSCISDFLDYMGIK---GPRMPLGFTF 601
Cdd:PTZ00107  83 GTNFRAVRVSLRGGGK--MERTQSKFSLPKSALLGekglldkkaTATDLFDHIAKSIKKMMEENGDPedlNKPVPVGFTF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 602 SFPCKQTSLDCGILITWTKGFK----ATDCV-GHDVATLLRDAVKRrEEFDLDVVAVVNDTVGTMMTCAYEE----PSCE 672
Cdd:PTZ00107 161 SFPCTQLSVNNAILIDWTKGFEtgraTNDPVeGKDVGELLNDAFKR-NNVPANVVAVLNDTVGTLISCAYQKpkntPPCQ 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 673 IGLIVGTGSNACYME-EMKNVemveGNQGQMcINMEWGAFgdngCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGE 751
Cdd:PTZ00107 240 VGVIIGTGSNACYFEpEVSAY----GYAGTP-INMECGNF----DSKLPITPYDLEMDWYTPNRGRQQFEKMISGAYLGE 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 752 IVRNILIDftkkgfLFRGQISEPLKTRGIFETKFLSQIESDRLALLQ-VRAILQQL-GLNSTCDDSILVKTVCGVVSKRA 829
Cdd:PTZ00107 311 ISRRLIVH------LLQLKAPPKMWQSGSFESEDASMILNDQSPDLQfSRQVIKEAwDVDLTDEDLYTIRKICELVRGRA 384
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568966727 830 AQLCGAGMAAVVEKIRENRGLdhlnVTVGVDGTLYKLHPHFSRIMHQTVKE-LSPK-CTVSFLLSEDGSGKGAALITAV 906
Cdd:PTZ00107 385 AQLAAAFIAAPAKKTRTVQGK----ATVAIDGSVYVKNPWFRRLLQEYINSiLGPDaGNVVFYLADDGSGKGAAIIAAM 459
Hexokinase_2 pfam03727
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
224-458 4.74e-102

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam00349. Some members of the family have two copies of each of these domains.


Pssm-ID: 427467  Cd Length: 238  Bit Score: 317.13  E-value: 4.74e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  224 EVGLIIGTGTNACYMEELRHIDLVEGD---EGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMY 300
Cdd:pfam03727   1 RIGLILGTGTNAAYVEKVSNIPKLEGKlpkSGEMIINTEWGAFGDNGLLPLPRTEYDKELDAESPNPGFQPFEKMISGMY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  301 MGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDK-EGVQNAKEILTR-LGVE-PSHDDCVSVQHVCTIV 377
Cdd:pfam03727  81 LGELVRLVLLDLAEEGLLFGGQLPEKLKTPYSLDTSFLSAIESDPsEDLETTREILEElLGIEtCTEEDRKIVRRICEAV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  378 SFRSANLVAATLGAILNRLRDNkgtprlRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDS---DVRFLLSESGSGKGAAM 454
Cdd:pfam03727 161 STRAARLVAAGIAAILKKIGGG------RVTVGVDGSVYEKYPGFRERLQEALRELLGPEledKVVLVLAEDGSGVGAAL 234

                  ....
gi 568966727  455 VTAV 458
Cdd:pfam03727 235 IAAV 238
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
467-906 2.45e-99

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 318.58  E-value: 2.45e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 467 RQIEETLSHFRLSKQALMEVKKKLRSEMEMGLrkETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIrs 546
Cdd:COG5026   19 QAVEELVESFTVPTEDLREVVKAFIEELEKGL--QPKSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVL-- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 547 GKKRTVEMHNKIYSIPLEIMQG-TGDELFDHIVSCISDFLD--YMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFK 623
Cdd:COG5026   95 GGDGTFDIEQSKSFLPVECRDSeSRDELFGFIADRLAAFIKeqHPSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 624 ATDCVGHDVATLLRDAVKRREeFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQ---- 699
Cdd:COG5026  175 IPEVIGTDVVRLLQEALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDDlpet 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 700 GQMCINMEWGAFgDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 779
Cdd:COG5026  254 GPMLINCEWGSF-DNELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPF 332
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 780 IFETKFLSQIESDR-LALLQVRAILQQ-LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDhlnvtV 857
Cdd:COG5026  333 ALSTSVLSRIEEDPfENLRNTLTTFLNdFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYKAYH-----V 407
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568966727 858 GVDGTLYKLHPHFSRIMHQTVKEL--SPKCTVSFLLSEDGSGKGAALITAV 906
Cdd:COG5026  408 GADGSVIERYPGFRSMLREALKALlgEEGEKIKIKPAEDGSGLGAALCALL 458
PLN02914 PLN02914
hexokinase
7-457 3.20e-96

hexokinase


Pssm-ID: 178502 [Multi-domain]  Cd Length: 490  Bit Score: 311.43  E-value: 3.20e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727   7 PSVPCGGAGAWEARIDKYLYAMRLSDEILIDILTRFKKE------------------MKNGLSRDynPTASVKMLPTFVR 68
Cdd:PLN02914   9 PAIGSFTFSSRPRRRPRSRMAVRSNAVSVAPILTKLQKDcatplpvlrhvadamaadMRAGLAVD--GGGDLKMILSYVD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  69 SIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIK----- 143
Cdd:PLN02914  87 SLPSGNEKGLFYALDLGGTNFRVLRVQLGGKDERVIATEFEQVSIPQELMFGTSEELFDFIASGLANFVAKEGGKfhlpe 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 144 DKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGdYDANIVAVVNDTVGTMMTCGYDDQQC 223
Cdd:PLN02914 167 GRKREIGFTFSFPVKQTSIDSGILMKWTKGFAVSGTAGKDVVACLNEAMERQG-LDMRVSALVNDTVGTLAGARYWDDDV 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 224 EVGLIIGTGTNACYMEELRHIDLVEGDE---GRMCINTEWGAFGDDGSLedirTEFDRELDRGSLNPGKQLFEKMVSGMY 300
Cdd:PLN02914 246 MVAVILGTGTNACYVERTDAIPKLQGQKsssGRTIINTEWGAFSDGLPL----TEFDREMDAASINPGEQIFEKTISGMY 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 301 MGELVRLILVKMAKESLLFeGRITPE-LLTRGKFTTSDVAAIETD-KEGVQNAKEILTR-LGVEPSHDDCVSVQHVCTIV 377
Cdd:PLN02914 322 LGEIVRRVLLKMAETSDLF-GHFVPEkLSTPFALRTPHLCAMQQDnSDDLQAVGSILYDvLGVEASLSARRRVVEVCDTI 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 378 SFRSANLVAATLGAILNRL-RDNKGT-PRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRFLLSESGSGKGA 452
Cdd:PLN02914 401 VKRGGRLAGAGIVGILEKMeEDSKGMiFGKRTVVAMDGGLYEKYPQYRRYMQDAVTELLGLelsKNIAIEHTKDGSGIGA 480

                 ....*
gi 568966727 453 AMVTA 457
Cdd:PLN02914 481 ALLAA 485
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
468-666 3.54e-95

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 297.50  E-value: 3.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  468 QIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSraTVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIrsG 547
Cdd:pfam00349   1 ALEELLKQFALSDEKLKEIVDRFVEEMEKGLAKEGSS--SLKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVEL--G 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  548 KKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIK---GPRMPLGFTFSFPCKQTSLDCGILITWTKGFKA 624
Cdd:pfam00349  77 GDGKFSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEdfeEKELPLGFTFSFPVQQTSLDSGTLIRWTKGFDI 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 568966727  625 TDCVGHDVATLLRDAVKRREEfDLDVVAVVNDTVGTMMTCAY 666
Cdd:pfam00349 157 PGVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
PLN02914 PLN02914
hexokinase
483-905 1.08e-92

hexokinase


Pssm-ID: 178502 [Multi-domain]  Cd Length: 490  Bit Score: 301.80  E-value: 1.08e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 483 LMEVKKKLRSEMEMGLRKETNSraTVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIP 562
Cdd:PLN02914  55 LRHVADAMAADMRAGLAVDGGG--DLKMILSYVDSLPSGNEKGLFYALDLGGTNFRVLRVQLGGKDERVIATEFEQVSIP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 563 LEIMQGTGDELFDHIVSCISDFLDYMGIK-----GPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLR 637
Cdd:PLN02914 133 QELMFGTSEELFDFIASGLANFVAKEGGKfhlpeGRKREIGFTFSFPVKQTSIDSGILMKWTKGFAVSGTAGKDVVACLN 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 638 DAVKrREEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQ---GQMCINMEWGAFGDN 714
Cdd:PLN02914 213 EAME-RQGLDMRVSALVNDTVGTLAGARYWDDDVMVAVILGTGTNACYVERTDAIPKLQGQKsssGRTIINTEWGAFSDG 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 715 GCLddirTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRL 794
Cdd:PLN02914 292 LPL----TEFDREMDAASINPGEQIFEKTISGMYLGEIVRRVLLKMAETSDLFGHFVPEKLSTPFALRTPHLCAMQQDNS 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 795 ALLQ-VRAILQQ-LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIREN-RGLDHLNVT-VGVDGTLYKLHPHF 870
Cdd:PLN02914 368 DDLQaVGSILYDvLGVEASLSARRRVVEVCDTIVKRGGRLAGAGIVGILEKMEEDsKGMIFGKRTvVAMDGGLYEKYPQY 447
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 568966727 871 SRIMHQTVKE-LSPKCTVSFLL--SEDGSGKGAALITA 905
Cdd:PLN02914 448 RRYMQDAVTElLGLELSKNIAIehTKDGSGIGAALLAA 485
COG5026 COG5026
Hexokinase [Carbohydrate transport and metabolism];
33-459 1.02e-83

Hexokinase [Carbohydrate transport and metabolism];


Pssm-ID: 227359 [Multi-domain]  Cd Length: 466  Bit Score: 276.98  E-value: 1.02e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  33 EILIDILTRFKKEMKNGLSRdyNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSqnVSMESEVYD 112
Cdd:COG5026   33 EDLREVVKAFIEELEKGLQP--KSGDFLPMIPTWVAPLPTGNESGSVLAIDLGGTNLRVCLVVLGGDGT--FDIEQSKSF 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 113 TPENIVHG-SGSQLFDHVAECLGDFMEKR--KIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLN 189
Cdd:COG5026  109 LPVECRDSeSRDELFGFIADRLAAFIKEQhpSGYGSKLPIGFTFSYPLNQTSINEGQLIRWTKGFDIPEVIGTDVVRLLQ 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 190 KAIKKRGdYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGD----EGRMCINTEWGAFgD 265
Cdd:COG5026  189 EALSARN-LPIRVVAVINDTTGTLLASVYTSSETIIGIIFGTGTNGCYCEPKGRIPKLPRDdlpeTGPMLINCEWGSF-D 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 266 DGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDK 345
Cdd:COG5026  267 NELSVLPRTKYDVLIDQESPNPGHQIFEKMSSGMYLGELLRLILRNLYEQGLIFNGQDPEKLTDPFALSTSVLSRIEEDP 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 346 -EGVQNAKEILTR-LGVEPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKgtprlRTTVGVDGSLYKMHPQYS 423
Cdd:COG5026  347 fENLRNTLTTFLNdFRAPTTKEERKLIRRLVELIGRRAARLAAVPIAAIVIKTGAYK-----AYHVGADGSVIERYPGFR 421
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 568966727 424 RRFHKTLRRLVPDSDVRFLL--SESGSGKGAAMVTAVA 459
Cdd:COG5026  422 SMLREALKALLGEEGEKIKIkpAEDGSGLGAALCALLA 459
Hexokinase_1 pfam00349
Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by ...
21-218 1.08e-81

Hexokinase; Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and pfam03727. Some members of the family have two copies of each of these domains.


Pssm-ID: 425627 [Multi-domain]  Cd Length: 197  Bit Score: 261.67  E-value: 1.08e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727   21 IDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDynPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEK 100
Cdd:pfam00349   2 LEELLKQFALSDEKLKEIVDRFVEEMEKGLAKE--GSSSLKMLPTYVTSLPTGTEKGTFLALDLGGTNFRVCLVELGGDG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  101 SqnVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKD---KKLPVGFTFSFPCRQSKIDEAVLITWTKRFKAS 177
Cdd:pfam00349  80 K--FSITQEKYKIPEELMTGTGEELFDFIADCIAEFLKEHGLEDfeeKELPLGFTFSFPVQQTSLDSGTLIRWTKGFDIP 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 568966727  178 GVEGADVVKLLNKAIKKRGDyDANIVAVVNDTVGTMMTCGY 218
Cdd:pfam00349 158 GVVGKDVVQLLQEALERRGL-PVKVVALVNDTVGTLMAGAY 197
PLN02405 PLN02405
hexokinase
483-905 3.47e-81

hexokinase


Pssm-ID: 215226 [Multi-domain]  Cd Length: 497  Bit Score: 271.32  E-value: 3.47e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 483 LMEVKKKLRSEMEMGLRKETNSRatVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIP 562
Cdd:PLN02405  55 LRQVADAMTVEMHAGLASEGGSK--LKMLISYVDNLPSGDEKGLFYALDLGGTNFRVLRVLLGGKDGRVVKQEFEEVSIP 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 563 LEIMQGTGDELFDHIVSCISDFL-----DYMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLR 637
Cdd:PLN02405 133 PHLMTGSSDALFDFIAAALAKFVategeDFHLPPGRQRELGFTFSFPVKQTSISSGTLIKWTKGFSIDDAVGQDVVGELT 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 638 DAVKRReEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDN 714
Cdd:PLN02405 213 KAMERV-GLDMRVSALVNDTIGTLAGGRYYNPDVVAAVILGTGTNAAYVERAQAIPKWHGllpKSGEMVINMEWGNFRSS 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 715 GClddIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRL 794
Cdd:PLN02405 292 HL---PLTEYDHALDVESLNPGEQIFEKIISGMYLGEILRRVLLKMAEEAAFFGDTVPPKLKIPFILRTPDMSAMHHDTS 368
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 795 ALLQV-----RAILQQlgLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIREN--RGLDHLNVTVGVDGTLYKLH 867
Cdd:PLN02405 369 PDLKVvgsklKDILEI--PNTSLKMRKVVVELCNIVATRGARLSAAGIYGILKKLGRDtvKDGEKQKSVIAMDGGLFEHY 446
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 568966727 868 PHFSRIMHQTVKEL---SPKCTVSFLLSEDGSGKGAALITA 905
Cdd:PLN02405 447 TEFSKCMESTLKELlgeEVSESIEVEHSNDGSGIGAALLAA 487
PLN02362 PLN02362
hexokinase
483-905 1.76e-78

hexokinase


Pssm-ID: 215206 [Multi-domain]  Cd Length: 509  Bit Score: 264.44  E-value: 1.76e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 483 LMEVKKKLRSEMEMGLRKETNSRatVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLlvKIRSGKKRT------VEMHn 556
Cdd:PLN02362  55 LRQVVDAMAVEMHAGLASEGGSK--LKMLLTFVDDLPTGSEIGTYYALDLGGTNFRVL--RVQLGGQRSsilsqdVERH- 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 557 kiySIPLEIMQGTGDELFDHIVSCISDFLDYMG-----IKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHD 631
Cdd:PLN02362 130 ---PIPQHLMNSTSEVLFDFIASSLKQFVEKEEngsefSQVRRRELGFTFSFPVKQTSISSGILIKWTKGFAISDMVGKD 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 632 VATLLRDAVKRReEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEW 708
Cdd:PLN02362 207 VAECLQGALNRR-GLDMRVAALVNDTVGTLALGHYHDPDTVAAVIIGTGTNACYLERTDAIIKCQGlltTSGSMVVNMEW 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 709 GAFGDNGClddIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFrGQISEPLKTRGIFETKFLSQ 788
Cdd:PLN02362 286 GNFWSSHL---PRTSYDIDLDAESPNPNDQGFEKMISGMYLGDIVRRVILRMSQESDIF-GPVSSRLSTPFVLRTPSVAA 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 789 I-ESDRLALLQVRAILQQ-LGLNST-CDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKI-RE---------NRGLDHL-- 853
Cdd:PLN02362 362 MhEDDSPELQEVARILKEtLGISEVpLKVRKLVVKICDVVTRRAARLAAAGIVGILKKIgRDgsggitsgrSRSDIQImr 441
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568966727 854 NVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLL---SEDGSGKGAALITA 905
Cdd:PLN02362 442 RTVVAVEGGLYTNYTMFREYLHEALNEILGEDVAQHVIlkaTEDGSGIGSALLAA 496
PLN02405 PLN02405
hexokinase
45-457 5.71e-75

hexokinase


Pssm-ID: 215226 [Multi-domain]  Cd Length: 497  Bit Score: 254.37  E-value: 5.71e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  45 EMKNGLSRDYNptASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQ 124
Cdd:PLN02405  65 EMHAGLASEGG--SKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVLRVLLGGKDGRVVKQEFEEVSIPPHLMTGSSDA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 125 LFDHVAECLGDFMEKRKiKDKKLP------VGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGdY 198
Cdd:PLN02405 143 LFDFIAAALAKFVATEG-EDFHLPpgrqreLGFTFSFPVKQTSISSGTLIKWTKGFSIDDAVGQDVVGELTKAMERVG-L 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 199 DANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGD---EGRMCINTEWGAFGddgSLEDIRTE 275
Cdd:PLN02405 221 DMRVSALVNDTIGTLAGGRYYNPDVVAAVILGTGTNAAYVERAQAIPKWHGLlpkSGEMVINMEWGNFR---SSHLPLTE 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 276 FDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETD-----KEGVQN 350
Cdd:PLN02405 298 YDHALDVESLNPGEQIFEKIISGMYLGEILRRVLLKMAEEAAFFGDTVPPKLKIPFILRTPDMSAMHHDtspdlKVVGSK 377
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 351 AKEIL----TRLGVEPshddcvSVQHVCTIVSFRSANLVAATLGAILNRL-RDN-KGTPRLRTTVGVDGSLYKMHPQYSR 424
Cdd:PLN02405 378 LKDILeipnTSLKMRK------VVVELCNIVATRGARLSAAGIYGILKKLgRDTvKDGEKQKSVIAMDGGLFEHYTEFSK 451
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 568966727 425 RFHKTLRRLVPDS---DVRFLLSESGSGKGAAMVTA 457
Cdd:PLN02405 452 CMESTLKELLGEEvseSIEVEHSNDGSGIGAALLAA 487
PLN02362 PLN02362
hexokinase
45-457 1.74e-74

hexokinase


Pssm-ID: 215206 [Multi-domain]  Cd Length: 509  Bit Score: 253.27  E-value: 1.74e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  45 EMKNGLSRDYNptASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQ 124
Cdd:PLN02362  65 EMHAGLASEGG--SKLKMLLTFVDDLPTGSEIGTYYALDLGGTNFRVLRVQLGGQRSSILSQDVERHPIPQHLMNSTSEV 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 125 LFDHVAECLGDFMEKRKIKDKKLPV-----GFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGdYD 199
Cdd:PLN02362 143 LFDFIASSLKQFVEKEENGSEFSQVrrrelGFTFSFPVKQTSISSGILIKWTKGFAISDMVGKDVAECLQGALNRRG-LD 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 200 ANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFgddGSLEDIRTEF 276
Cdd:PLN02362 222 MRVAALVNDTVGTLALGHYHDPDTVAAVIIGTGTNACYLERTDAIIKCQGlltTSGSMVVNMEWGNF---WSSHLPRTSY 298
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 277 DRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFeGRITPELLTRGKFTTSDVAAI-ETDKEGVQNAKEIL 355
Cdd:PLN02362 299 DIDLDAESPNPNDQGFEKMISGMYLGDIVRRVILRMSQESDIF-GPVSSRLSTPFVLRTPSVAAMhEDDSPELQEVARIL 377
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 356 T-RLGV-EPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRL-RDNKG-----------TPRLRTTVGVDGSLYKMHPQ 421
Cdd:PLN02362 378 KeTLGIsEVPLKVRKLVVKICDVVTRRAARLAAAGIVGILKKIgRDGSGgitsgrsrsdiQIMRRTVVAVEGGLYTNYTM 457
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 568966727 422 YSRRFHKTLRRLVPDSDVRFLL---SESGSGKGAAMVTA 457
Cdd:PLN02362 458 FREYLHEALNEILGEDVAQHVIlkaTEDGSGIGSALLAA 496
PLN02596 PLN02596
hexokinase-like
483-907 6.32e-52

hexokinase-like


Pssm-ID: 178206  Cd Length: 490  Bit Score: 189.70  E-value: 6.32e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 483 LMEVKKKLRSEMEMGLRKETNSraTVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIP 562
Cdd:PLN02596  56 LWEVADALVSDMTASLTAEETT--TLNMLVSYVASLPSGDEKGLYYGLNLRGSNFLLLRARLGGKNEPISDLYREEISIP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 563 LEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMP-----LGFTFSFPCKQTSLDCGILITWtKGFKATDCVGHDVATLLR 637
Cdd:PLN02596 134 SNVLNGTSQELFDYIALELAKFVAEHPGDEADTPervkkLGFTVSYPVDQAAASSGSAIKW-KSFSADDTVGKALVNDIN 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 638 DAVKrREEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEG---NQGQMCINMEWGAFgdN 714
Cdd:PLN02596 213 RALE-KHGLKIRVFALVDDTIGNLAGGRYYNKDTVAAVTLGMGTNAAYVEPAQAIPKWQSpspESQEIVISTEWGNF--N 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 715 GCLDDIrTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRL 794
Cdd:PLN02596 290 SCHLPI-TEFDASLDAESSNPGSRIFEKLTSGMYLGEIVRRVLLKMAEETALFGDTLPPKLTTPYLLRSPDMAAMHQDTS 368
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 795 ALLQV--RAILQQLGL-NSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIREnrgLDHLNVTVGVDGTLYKLHPHFS 871
Cdd:PLN02596 369 EDHEVvnEKLKEIFGItDSTPMAREVVAEVCDIVAERGARLAGAGIVGIIKKLGR---IENKKSVVTVEGGLYEHYRVFR 445
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 568966727 872 RIMHQTV-----KELSPKCTVSFllSEDGSGKGAALITAVG 907
Cdd:PLN02596 446 NYLHSSVwemlgSELSDNVVIEH--SHGGSGAGALFLAACQ 484
PLN02596 PLN02596
hexokinase-like
57-457 1.93e-50

hexokinase-like


Pssm-ID: 178206  Cd Length: 490  Bit Score: 185.47  E-value: 1.93e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  57 TASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDF 136
Cdd:PLN02596  76 TTTLNMLVSYVASLPSGDEKGLYYGLNLRGSNFLLLRARLGGKNEPISDLYREEISIPSNVLNGTSQELFDYIALELAKF 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 137 MEKRKIKDKKLP-----VGFTFSFPCRQSKIDEAVLITWtKRFKASGVEGADVVKLLNKAIKKRGdYDANIVAVVNDTVG 211
Cdd:PLN02596 156 VAEHPGDEADTPervkkLGFTVSYPVDQAAASSGSAIKW-KSFSADDTVGKALVNDINRALEKHG-LKIRVFALVDDTIG 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 212 TMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGddgSLEDIRTEFDRELDRGSLNPG 288
Cdd:PLN02596 234 NLAGGRYYNKDTVAAVTLGMGTNAAYVEPAQAIPKWQSpspESQEIVISTEWGNFN---SCHLPITEFDASLDAESSNPG 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 289 KQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETD---KEGVQNAK--EILTRLGVEPS 363
Cdd:PLN02596 311 SRIFEKLTSGMYLGEIVRRVLLKMAEETALFGDTLPPKLTTPYLLRSPDMAAMHQDtseDHEVVNEKlkEIFGITDSTPM 390
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 364 HDDCVSvqHVCTIVSFRSANLVAATLGAILNRLR--DNKgtprlRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD--SD- 438
Cdd:PLN02596 391 AREVVA--EVCDIVAERGARLAGAGIVGIIKKLGriENK-----KSVVTVEGGLYEHYRVFRNYLHSSVWEMLGSelSDn 463
                        410
                 ....*....|....*....
gi 568966727 439 VRFLLSESGSGKGAAMVTA 457
Cdd:PLN02596 464 VVIEHSHGGSGAGALFLAA 482
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
80-261 1.51e-13

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 69.93  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727  80 IALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVhgsGSQLFDHVAECLGDFMEKRKikDKKLPVGFTFSFPCRQ 159
Cdd:cd00012    1 LGIDIGSTSTKAGVADLDGEILPEEIVPTPVGRPGAVTD---LDELEEALRELLKEALRQLK--SEIDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 160 SKIDEAVLITWtkrfkasgvegadvvkLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY--DDQQCEVGLIIGTG-TNAC 236
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGtTGIA 139
                        170       180
                 ....*....|....*....|....*
gi 568966727 237 YMEElrhidlvegDEGRMCINTEWG 261
Cdd:cd00012  140 IVED---------GKGGVGAAGELG 155
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
528-728 4.44e-12

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 65.69  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 528 LALDLGGTNFRVLLVKIRsgkKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKgpRMPLGFTFSFPCKQ 607
Cdd:cd00012    1 LGIDIGSTSTKAGVADLD---GEILPEEIVPTPVGRPGAVTDLDELEEALRELLKEALRQLKSE--IDAVGITEPGGVPK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568966727 608 TSLDCGILITWtkgfkatdcvghdvatLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAY--EEPSCEIGLIVGTGS-NAC 684
Cdd:cd00012   76 ENREVIILPNL----------------LLIPLALALEDLGGVPVAVVNDAVAAALAEGLfgKEEDTVLVVDLGTGTtGIA 139
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568966727 685 YMEEMKnvemvegnqGQMCINMEWG-AFGDNGCLDDIRTDFDKVV 728
Cdd:cd00012  140 IVEDGK---------GGVGAAGELGiAEALAAVLNLLDGLPDAVV 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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