Hipk2 homeodomain interacting protein kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hipk2provided by MGI
Official Full Name: homeodomain interacting protein kinase 2provided by MGI
Primary source: MGI:MGI:1314872
See related: Ensembl:ENSMUSG00000061436 AllianceGenome:MGI:1314872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stank; 1110014O20Rik; B230339E18Rik
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; metanephros; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 22.0), subcutaneous fat pad adult (RPKM 17.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 B1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (38664447..38853236, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (38687512..38876331, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells.
Title: ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells.
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.
Title: Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Title: HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
MiR-221-3p targets HIPK2 to promote diabetic wound healing.
Title: MiR-221-3p targets HIPK2 to promote diabetic wound healing.
HIPK2 phosphorylates HDAC3 for NF-kappaB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Title: HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis.
Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.
Title: Phenotypic Effects of Homeodomain-Interacting Protein Kinase 2 Deletion in Mice.
Tubular HIPK2 is a key contributor to renal fibrosis.
Title: Tubular HIPK2 is a key contributor to renal fibrosis.
Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
Title: Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion.
Title: IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion.
The loss of HIPK2 increases cytosolic and mitochondrial Parkin protein levels under basal conditions and upon exposure to mitochondrial toxins, which protect mitochondria from toxin-induced damage
Title: Loss of HIPK2 Protects Neurons from Mitochondrial Toxins by Regulating Parkin Protein Turnover.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Mit80 (e-PCR), detects polymorphism
- UniSTS:116605

29.MMHAP37FRB11.seq (e-PCR)
- UniSTS:123860

GDB:4585413 (e-PCR)
- UniSTS:76007

Homology

Orthologs from Annotation Pipeline: 473 organisms have orthologs with human gene Hipk2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in iris morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens induction in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within voluntary musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with PML body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	TAS Traceable Author Statement more info	PubMed
part_of RNA polymerase II transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeodomain-interacting protein kinase 2

Names: nuclear body-associated kinase 1; sialophorin tail-associated nuclear serine/threonine-protein kinase

NP_001129537.1

EC 2.7.11.1

NP_001281072.1

EC 2.7.11.1

NP_001281073.1

EC 2.7.11.1

NP_034563.2

EC 2.7.11.1

XP_006505665.1

EC 2.7.11.1

XP_006505666.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136065.2 → NP_001129537.1 homeodomain-interacting protein kinase 2 isoform 1

See identical proteins and their annotated locations for NP_001129537.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) has multiple differences compared to variant 2. These differences result in a distinct 5' UTR, and cause translation initiation at a downstream start codon, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.

Source sequence(s)

AF208292, AK016742, BM122543

Consensus CDS

CCDS51752.1

UniProtKB/Swiss-Prot

Q9QZR5

UniProtKB/TrEMBL

A0A0R4J204

Related

ENSMUSP00000125572.2, ENSMUST00000160962.8

Conserved Domains (2) summary

smart00220
Location:192 → 520

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:176 → 530

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
NM_001294143.1 → NP_001281072.1 homeodomain-interacting protein kinase 2 isoform 3

See identical proteins and their annotated locations for NP_001281072.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region compared to variant 2. The encoded isoform (3) is shorter than isoform 2.

Source sequence(s)

AC154016, AF170301, BM122543

Consensus CDS

CCDS80527.1

UniProtKB/Swiss-Prot

Q9QZR5

UniProtKB/TrEMBL

Q5D0E9

Related

ENSMUSP00000125150.2, ENSMUST00000162359.8

Conserved Domains (2) summary

smart00220
Location:199 → 527

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
NM_001294144.1 → NP_001281073.1 homeodomain-interacting protein kinase 2 isoform 4

See identical proteins and their annotated locations for NP_001281073.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses two alternate in-frame splice sites in the coding region compared to variant 2. The encoded isoform (4) is shorter than isoform 2.

Source sequence(s)

AC118613, AC154016, AC161147

Consensus CDS

CCDS80526.1

UniProtKB/Swiss-Prot

Q9QZR5

UniProtKB/TrEMBL

A0A0R4J202

Related

ENSMUSP00000125500.2, ENSMUST00000160360.2

Conserved Domains (2) summary

smart00220
Location:199 → 527

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
NM_010433.2 → NP_034563.2 homeodomain-interacting protein kinase 2 isoform 2

See identical proteins and their annotated locations for NP_034563.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AC154016, AF170302, BM122543

Consensus CDS

CCDS20017.2

UniProtKB/Swiss-Prot

Q9QZR4, Q9QZR5

Related

ENSMUSP00000124133.2, ENSMUST00000161779.8

Conserved Domains (2) summary

smart00220
Location:199 → 527

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

38664447..38853236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505602.5 → XP_006505665.1 homeodomain-interacting protein kinase 2 isoform X1

Conserved Domains (1) summary

cd14227
Location:183 → 537

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
XM_006505603.4 → XP_006505666.1 homeodomain-interacting protein kinase 2 isoform X2

Conserved Domains (1) summary

cd14227
Location:176 → 530

STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2