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HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 28996, updated on 4-Dec-2022

Summary

Official Symbol
HIPK2provided by HGNC
Official Full Name
homeodomain interacting protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:14402
See related
Ensembl:ENSG00000064393 MIM:606868; AllianceGenome:HGNC:14402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO0593
Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues See more
Orthologs
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Genomic context

See HIPK2 in Genome Data Viewer
Location:
7q34
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139561570..139777998, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140874868..141091290, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139246316..139477797, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene C-type lectin domain family 2 member L Neighboring gene ERH pseudogene 1 Neighboring gene uncharacterized LOC105375530 Neighboring gene Sharpr-MPRA regulatory region 6205 Neighboring gene Sharpr-MPRA regulatory region 3006 Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC107986853

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23711, DKFZp686K02111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables virion binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in PML body organization TAS
Traceable Author Statement
more info
PubMed 
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia TAS
Traceable Author Statement
more info
PubMed 
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in eye development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
Traceable Author Statement
more info
PubMed 
involved_in iris morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in lens induction in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in retina layer formation IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in voluntary musculoskeletal movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeodomain-interacting protein kinase 2
Names
hHIPk2
NP_001106710.1
NP_073577.3
XP_011514379.1
XP_011514380.1
XP_011514381.1
XP_011514382.1
XP_011514383.1
XP_047276216.1
XP_047276217.1
XP_047276218.1
XP_047276219.1
XP_047276220.1
XP_047276221.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113239.3NP_001106710.1  homeodomain-interacting protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001106710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter, as compared to isoform 1.
    Source sequence(s)
    AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
    Consensus CDS
    CCDS75666.1
    UniProtKB/Swiss-Prot
    Q9H2X6
    Related
    ENSP00000413724.2, ENST00000428878.6
    Conserved Domains (2) summary
    smart00220
    Location:199527
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:183537
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  2. NM_022740.5NP_073577.3  homeodomain-interacting protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_073577.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the full-length isoform (1).
    Source sequence(s)
    AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
    Consensus CDS
    CCDS75667.1
    UniProtKB/Swiss-Prot
    Q9H2X6, Q9H2Y1
    Related
    ENSP00000385571.3, ENST00000406875.8
    Conserved Domains (2) summary
    smart00220
    Location:199527
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:183537
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    139561570..139777998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420265.1XP_047276221.1  homeodomain-interacting protein kinase 2 isoform X8

  2. XM_047420260.1XP_047276216.1  homeodomain-interacting protein kinase 2 isoform X6

  3. XM_047420264.1XP_047276220.1  homeodomain-interacting protein kinase 2 isoform X7

  4. XM_047420261.1XP_047276217.1  homeodomain-interacting protein kinase 2 isoform X7

  5. XM_047420262.1XP_047276218.1  homeodomain-interacting protein kinase 2 isoform X7

  6. XM_047420263.1XP_047276219.1  homeodomain-interacting protein kinase 2 isoform X7

  7. XM_011516080.4XP_011514382.1  homeodomain-interacting protein kinase 2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  8. XM_011516079.4XP_011514381.1  homeodomain-interacting protein kinase 2 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  9. XM_011516078.4XP_011514380.1  homeodomain-interacting protein kinase 2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  10. XM_011516077.4XP_011514379.1  homeodomain-interacting protein kinase 2 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  11. XM_011516081.3XP_011514383.1  homeodomain-interacting protein kinase 2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:207535
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:191545
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    140874868..141091290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)