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HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 28996, updated on 11-Sep-2019

Summary

Official Symbol
HIPK2provided by HGNC
Official Full Name
homeodomain interacting protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:14402
See related
Ensembl:ENSG00000064393 MIM:606868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO0593
Summary
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues See more
Orthologs

Genomic context

See HIPK2 in Genome Data Viewer
Location:
7q34
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (139561570..139777998, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139415730..139477693, complement) , (139246316..139342363, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene C-type lectin domain family 2 member L Neighboring gene ERH pseudogene 1 Neighboring gene uncharacterized LOC105375530 Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC107986853 Neighboring gene uncharacterized LOC105375532

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    C-MYB transcription factor network, organism-specific biosystem
    C-MYB transcription factor network
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Physiological factors, organism-specific biosystem (from REACTOME)
    Physiological factors, organism-specific biosystemCardiovascular homeostasis can be regulated by natriuretic peptides (Pandey 2014).
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
    YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23711, DKFZp686K02111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II activating transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
virion binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
PML body organization TAS
Traceable Author Statement
more info
PubMed 
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia TAS
Traceable Author Statement
more info
PubMed 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
eye development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intrinsic apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
Traceable Author Statement
more info
PubMed 
iris morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lens induction in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
modulation by virus of host morphology or physiology NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
retina layer formation IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
voluntary musculoskeletal movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeodomain-interacting protein kinase 2
Names
hHIPk2
NP_001106710.1
NP_073577.3
XP_006715998.1
XP_011514379.1
XP_011514380.1
XP_011514381.1
XP_011514382.1
XP_011514383.1
XP_016867558.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113239.3NP_001106710.1  homeodomain-interacting protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001106710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter, as compared to isoform 1.
    Source sequence(s)
    AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
    Consensus CDS
    CCDS75666.1
    UniProtKB/Swiss-Prot
    Q9H2X6
    Related
    ENSP00000413724.2, ENST00000428878.6
    Conserved Domains (2) summary
    smart00220
    Location:199527
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:183537
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  2. NM_022740.5NP_073577.3  homeodomain-interacting protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_073577.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the full-length isoform (1).
    Source sequence(s)
    AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
    Consensus CDS
    CCDS75667.1
    UniProtKB/Swiss-Prot
    Q9H2X6
    Related
    ENSP00000385571.3, ENST00000406875.8
    Conserved Domains (2) summary
    smart00220
    Location:199527
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:183537
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    139561570..139777998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715935.2XP_006715998.1  homeodomain-interacting protein kinase 2 isoform X6

    Conserved Domains (2) summary
    smart00220
    Location:192520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:176530
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  2. XM_017012069.1XP_016867558.1  homeodomain-interacting protein kinase 2 isoform X6

    Conserved Domains (2) summary
    smart00220
    Location:192520
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:176530
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  3. XM_011516080.3XP_011514382.1  homeodomain-interacting protein kinase 2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  4. XM_011516079.3XP_011514381.1  homeodomain-interacting protein kinase 2 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  5. XM_011516078.3XP_011514380.1  homeodomain-interacting protein kinase 2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  6. XM_011516077.3XP_011514379.1  homeodomain-interacting protein kinase 2 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:378706
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:362716
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
  7. XM_011516081.2XP_011514383.1  homeodomain-interacting protein kinase 2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:207535
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14227
    Location:191545
    STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
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