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Hipk1 homeodomain interacting protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 15257, updated on 12-May-2024

Summary

Official Symbol
Hipk1provided by MGI
Official Full Name
homeodomain interacting protein kinase 1provided by MGI
Primary source
MGI:MGI:1314873
See related
Ensembl:ENSMUSG00000008730 AllianceGenome:MGI:1314873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myak; 1110062K04Rik
Summary
Predicted to enable protein serine/threonine kinase activity; protein tyrosine kinase activity; and transcription corepressor activity. Involved in adherens junction assembly; camera-type eye morphogenesis; and neuron differentiation. Acts upstream of or within several processes, including anterior/posterior pattern specification; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and smoothened signaling pathway. Located in PML body; cytoplasm; and nuclear speck. Is expressed in several structures, including forebrain ventricular layer and future forebrain. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 35.2), testis adult (RPKM 31.7) and 28 other tissues See more
Orthologs
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Genomic context

See Hipk1 in Genome Data Viewer
Location:
3 F2.2; 3 45.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103647131..103699210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103739815..103791894, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108168889 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103542020-103542203 Neighboring gene STARR-positive B cell enhancer ABC_E6093 Neighboring gene olfactomedin-like 3 Neighboring gene STARR-seq mESC enhancer starr_08602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103577942-103578125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103581922-103582188 Neighboring gene predicted gene 15886 Neighboring gene DNA cross-link repair 1B Neighboring gene STARR-positive B cell enhancer ABC_E11207 Neighboring gene predicted gene 15471 Neighboring gene adaptor-related protein complex AP-4, beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adherens junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic retina morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in iris morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lens induction in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in retina layer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
homeodomain-interacting protein kinase 1
Names
nuclear body-associated kinase 2
protein kinase Myak
NP_001288233.1
NP_001288235.1
NP_034562.2
XP_011238326.1
XP_036018798.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301304.1NP_001288233.1  homeodomain-interacting protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001288233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC132567
    Consensus CDS
    CCDS38576.1
    UniProtKB/Swiss-Prot
    A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
    Related
    ENSMUSP00000113998.2, ENSMUST00000118317.8
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  2. NM_001301306.1NP_001288235.1  homeodomain-interacting protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001288235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC132567
    Consensus CDS
    CCDS79992.1
    UniProtKB/Swiss-Prot
    O88904
    Related
    ENSMUSP00000102458.3, ENSMUST00000106845.9
    Conserved Domains (2) summary
    smart00220
    Location:190518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  3. NM_010432.2NP_034562.2  homeodomain-interacting protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_034562.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript ans encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC132567, AF170304, AK134408, AW125573
    Consensus CDS
    CCDS38576.1
    UniProtKB/Swiss-Prot
    A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
    Related
    ENSMUSP00000029438.9, ENSMUST00000029438.15
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

RNA

  1. NR_125731.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132567
    Related
    ENSMUST00000137078.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103647131..103699210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240024.2XP_011238326.1  homeodomain-interacting protein kinase 1 isoform X2

    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1
  2. XM_036162905.1XP_036018798.1  homeodomain-interacting protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    A6H5Z7, O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
    Conserved Domains (1) summary
    cd14228
    Location:174528
    STKc_HIPK1; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1

RNA

  1. XR_003954293.2 RNA Sequence

  2. XR_004941290.1 RNA Sequence