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Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex [ Mus musculus (house mouse) ]

Gene ID: 15126, updated on 8-Feb-2024

Summary

Official Symbol
Hba-xprovided by MGI
Official Full Name
hemoglobin X, alpha-like embryonic chain in Hba complexprovided by MGI
Primary source
MGI:MGI:96019
See related
Ensembl:ENSMUSG00000055609 AllianceGenome:MGI:96019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hbz
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within erythrocyte maturation and negative regulation of transcription by RNA polymerase II. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including alimentary system; dorsal aorta; extraembryonic component; liver; and placenta. Orthologous to human HBZ (hemoglobin subunit zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 2628.2) and CNS E11.5 (RPKM 744.9) See more
Orthologs
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Genomic context

See Hba-x in Genome Data Viewer
Location:
11 A4; 11 18.86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32226600..32228116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32276600..32278116)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rhomboid 5 homolog 1 Neighboring gene STARR-positive B cell enhancer ABC_E11473 Neighboring gene alpha-globin locus regulatory region Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene nitrogen permease regulator-like 3 Neighboring gene hemoglobin alpha, adult chain 1 Neighboring gene hemoglobin, theta 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in carbon dioxide transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
 
involved_in oxygen transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
part_of hemoglobin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
hemoglobin subunit zeta
Names
alpha-like embryonic globin chain x
hemaglobin zeta
hemoglobin zeta chain
zeta-globin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010405.4NP_034535.1  hemoglobin subunit zeta

    See identical proteins and their annotated locations for NP_034535.1

    Status: VALIDATED

    Source sequence(s)
    BC051988, BY111754
    Consensus CDS
    CCDS24522.1
    UniProtKB/Swiss-Prot
    P06467, Q61654
    UniProtKB/TrEMBL
    Q78PA4
    Related
    ENSMUSP00000020531.3, ENSMUST00000020531.9
    Conserved Domains (1) summary
    cd08927
    Location:7142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32226600..32228116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)