Conserved Protein Domain Family
Hb-alpha_like

?
cd08927: Hb-alpha_like 
Click on image for an interactive view with Cn3D
Hemoglobin alpha, zeta, mu, theta, and related Hb subunits
Hb is the oxygen transport protein of erythrocytes. It is an allosterically modulated heterotetramer. Hemoglobin A (HbA) is the most common Hb in adult humans, and is formed from two alpha-chains and two beta-chains (alpha2beta2). An equilibrium exists between deoxygenated/unliganded/T(tense state) Hb having low oxygen affinity, and oxygenated /liganded/R(relaxed state) Hb having a high oxygen affinity. Various endogenous heterotropic effectors bind Hb to modulate its oxygen affinity and cooperative behavior, e.g. hydrogen ions, chloride ions, carbon dioxide and 2,3-bisphosphoglycerate. Hb is also an allosterically regulated nitrite reductase; the plasma nitrite anion may be activated by hemoglobin in areas of hypoxia to bring about vasodilation. Other Hb types are: HbA2 (alpha2delta2) which in normal individuals, is naturally expressed at a low level; Hb Portland-1 (zeta2gamma2), Hb Gower-1 (zeta2epsilon2), and Hb Gower-2 (alpha2epsilon2), which are Hbs present during the embryonic period; and fetal hemoglobin (HbF, alpha2gamma2), the primary hemoglobin throughout most of gestation. These Hbs types have differences in O2 affinity and in their interactions with allosteric effectors.
Statistics
?
PSSM-Id: 271278
View PSSM: cd08927
Aligned: 34 rows
Threshold Bit Score: 188.165
Threshold Setting Gi: 4699569
Created: 14-Jun-2010
Updated: 11-Jun-2014
Structure
?
Program:
Drawing:
Aligned Rows:
Hierarchy
?
Display:
 
heme bindingtetramer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

cd08927 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd08927 is a member of the superfamily cl21461.
cd00454:TrHb1_Ncd01040:Mb_likecd01067:Globin_likecd01068:globin_sensorcd08916:TrHb3_Pcd08917:TrHb2_Ocd08919:PBP_likecd08920:Ngbcd08922:FHb-globincd08923:class1-2_nsHbs_Lbscd08924:Cygbcd08925:Hb-beta_likecd08926:Mbcd08927:Hb-alpha_likecd12124:Pgbscd12125:APC_alphacd12126:APC_betacd12127:PE-PC-PEC_betacd12128:PBP_PBS-LCMcd12129:PE-PC-PEC_alphacd12130:Aplcd12131:HGbI_likecd12137:GbXcd14755:GS_BA2291-HK_likecd14756:TrHbcd14757:GS_EcDosC-like_GGDEFcd14758:GS_GGDEF_1cd14759:GS_GGDEF_2cd14760:GS_PAS-GGDEF-EALcd14761:GS_GsGCS_likecd14762:GS_STAScd14763:SSDgbs_1cd14764:SSDgbs_2cd14765:Hbcd14766:CeGLB25_likecd14767:PE_beta_likecd14768:PC_PEC_betacd14769:PE_alphacd14770:PC-PEC_alphacd14771:TrHb2_Mt-trHbO-like_Ocd14772:TrHb2_Bs-trHb-like_Ocd14773:TrHb2_PhHbO-like_Ocd14774:TrHb2_O_1cd14775:TrHb2_O_2cd14776:HmpEc-globin_likecd14777:Yhb1-globin_likecd14778:VtHb-like_SDgbcd14779:FHP_Ae-globin_likecd14780:HmpPa-globin_likecd14781:FHb-globin_1cd14782:FHb-globin_2cd14783:FHb-globin_3cd14784:class1_nsHb_like1CG5 A1222811108319203MKB A1GCW A1224091224883928779581224191224171SPG A2577990152R1H A1PBX A3081968034HHB A1FDH A1SI4 A1223323517112241222958402930212228517081201222821222931223061708119739153501223351HBR A126631702747483841224211CG5 A1222811108319203MKB A1GCW A1224091224883928779581224191224171SPG A2577990152R1H A1PBX A3081968034HHB A1FDH A1SI4 A1223323517112241222958402930212228517081201222821222931223061708119739153501223351HBR A12663170274748384122421
cd08927 Sequence Cluster
cd08927 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
 cd08927 Branch
 Whole Hierarchy
 [Download CDTree]
CD Hierarchy
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #         ##               #  ##  #               
4HHB_A         2 LSPADKTNVKAAWGKvgAHAGEYGAEALERMFLSFPTTKTYFPHFd-LSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL 80
1CG5_A         2 LSSQNKKAIEELGNLikANAEAWGADALARLFELHPQTKTYFSKFsgFEACNEQVKKHGKRVMNALADATHHLDNLHLHL 81
3MKB_A         2 FTGVERSTIGAIAKIlaSTPEAYGAEALARLFATHPGAKSYFDYAd-YSAAGAKVQLHGGKVIRAVVSAAEHDDDLHAHL 80
1SI4_A         2 LSPADKTNVKAAWGKvgAHAGEYGAEALERMFLSFPTTKTYFPHFd-LSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL 80
1GCW_A         2 FTACEKQTIGKIAQVlaKSPEAYGAECLARLFVTHPGSKSYFEYKd-YSAAGAKVQVHGGKVIRAVVKAAEHVDDLHSHL 80
gi 110831920   3 LSDANKQEIHHVAELikPHAEAVGADALARLFELHPQTKTYFPNFsgYHATDAPVKAHGAKVINAVLKAAEHLDDLPKHL 82
gi 122417      2 LTAADKTLIKSIWGKveKETEAIGVEALVRLFKCFPQSKVYFDHFtdLSPSSQKLHAHAKVVLGALTKAVNHLDNITDTL 81
gi 122281      2 LSEGNKKAIKNLLQKihSQTEVLGAEALARLFECHPQTKSYFPKFsgFSANDKRVKHHGALVLKALVDTNKHLDDLPHHL 81
gi 122488      2 LSAADKTAIKHLTGSlrTNAEAWGAESLARMFATTPSTKTYFSKFtdFSANGKRVKAHGGKVLNAVADATDHLDNVAGHL 81
gi 122409      9 YSAADRAELAALSKVlaQNAEAFGAEALARMFTVYAATKSYFKDYkdFTAAAPSIKAHGAKVVTALAKACDHLDDLKTHL 88
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1          #   #         ##  #                                  #     
4HHB_A        81 SALSDLHAHkLRVDPVNFKLLSHCLLVTLAAHLPaeFTPAVHASLDKFLASVSTVLTSKYR 141
1CG5_A        82 EDLARKHGEnLLVDPHNFHLFADCIVVTLAVNLQa-FTPVTHCAVDKFLELVAYELSSCYR 141
3MKB_A        81 MVLAVTHGKkLLVDPSNFPMLSECILVTLATHLAe-FSPATHCAVDKLLSAISSELSSKYR 140
1SI4_A        81 SALSDLHAHkLRVDPVNFKLLSHCLLVTLAAHLPaeFTPAVHASLDKFLASVSTVLTSKYR 141
1GCW_A        81 ETLALTHGKkLLVDPQNFPMLSECIIVTLATHLTe-FSPDTHCAVDKLLSAICQELSSRYR 140
gi 110831920  83 EKLATKHGHeLLVDPHNFVLFSDIIVVTLATKLPt-FSPATHRAIDKFLEELVHQLSSKYR 142
gi 122417     82 HDISLVHAKkLLVDPVNFELLGHCLEVALAAHFAtdFTPEVHLAIDKFLYEVEKALFETYR 142
gi 122281     82 NKLAEKHGKgLLVDPHNFKLFSDCIAVTLAAHLQe-FSPETHCAVDKFLEEVTYQLSSLYR 141
gi 122488     82 DPLAVLHGTtLCVDPHNFPLLTQCILVTLAAHLTe-LKPETHCALDKFLCEVATALGSHYR 141
gi 122409     89 HKLATFHGSeLKVDPANFQYLSYCLEVALAVHLTe-FSPETHCALDKFLTNVCHELSSRYR 148

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap