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HBZ hemoglobin subunit zeta [ Homo sapiens (human) ]

Gene ID: 3050, updated on 8-Dec-2018

Summary

Official Symbol
HBZprovided by HGNC
Official Full Name
hemoglobin subunit zetaprovided by HGNC
Primary source
HGNC:HGNC:4835
See related
Ensembl:ENSG00000130656 MIM:142310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBZ1; HBZ-T1
Summary
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]
Expression
Biased expression in testis (RPKM 1.3), bone marrow (RPKM 0.5) and 1 other tissue See more
Orthologs

Genomic context

See HBZ in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (142422..154511)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (192921..204504)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene rhomboid 5 homolog 1 Neighboring gene N-methylpurine DNA glycosylase Neighboring gene alpha-globin locus control region Neighboring gene NPR3 like, GATOR1 complex subunit Neighboring gene uncharacterized LOC107983982 Neighboring gene hemoglobin subunit zeta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
oxygen transport IEA
Inferred from Electronic Annotation
more info
 
protein heterooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
hemoglobin subunit zeta
Names
HBAZ
hemoglobin zeta chain
hemoglobin, zeta
zeta-globin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005332.2NP_005323.1  hemoglobin subunit zeta

    See identical proteins and their annotated locations for NP_005323.1

    Status: REVIEWED

    Source sequence(s)
    M24173
    Consensus CDS
    CCDS10397.1
    UniProtKB/Swiss-Prot
    P02008
    Related
    ENSP00000252951.2, ENST00000252951.2
    Conserved Domains (1) summary
    cd08927
    Location:3142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    142422..154511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255287.3XP_005255344.1  hemoglobin subunit zeta isoform X1

    Conserved Domains (1) summary
    cd08927
    Location:15154
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits
  2. XM_005255288.3XP_005255345.1  hemoglobin subunit zeta isoform X2

    See identical proteins and their annotated locations for XP_005255345.1

    UniProtKB/Swiss-Prot
    P02008
    Conserved Domains (1) summary
    cd08927
    Location:3142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits
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