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H13 histocompatibility 13 [ Mus musculus (house mouse) ]

Gene ID: 14950, updated on 8-Jan-2023

Summary

Official Symbol
H13provided by MGI
Official Full Name
histocompatibility 13provided by MGI
Primary source
MGI:MGI:95886
See related
Ensembl:ENSMUSG00000019188 AllianceGenome:MGI:95886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spp; H-13; Hm13; PSL3; 1200006O09Rik; 4930443L17Rik; 5031424B04Rik
Summary
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Located in cell surface and endoplasmic reticulum membrane. Is expressed in several structures, including brain; embryo ectoderm; extraembryonic component; hemolymphoid system; and intervertebral disc. Orthologous to human HM13 (histocompatibility minor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.1), ovary adult (RPKM 28.7) and 28 other tissues See more
Orthologs
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Genomic context

See H13 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152511292..152550588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152669422..152708668)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030C14 gene Neighboring gene predicted gene, 31791 Neighboring gene malignant T cell amplified sequence 2 Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aspartic endopeptidase activity, intramembrane cleaving ISO
Inferred from Sequence Orthology
more info
 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane protein proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lumenal side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
minor histocompatibility antigen H13
Names
presenilin-like aspartyl protease
presenilin-like protein 3
signal peptide peptidase beta
NP_001153023.1
NP_001153024.1
NP_001153025.1
NP_034506.1
XP_006498846.1
XP_017171155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159551.2NP_001153023.1  minor histocompatibility antigen H13 isoform 1

    See identical proteins and their annotated locations for NP_001153023.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS50752.1
    UniProtKB/Swiss-Prot
    Q9D8V0
    UniProtKB/TrEMBL
    A0A6P5QYB5, A0A8C6MNU6
    Related
    ENSMUSP00000086460.3, ENSMUST00000089059.9
    Conserved Domains (1) summary
    pfam04258
    Location:62350
    Peptidase_A22B; Signal peptide peptidase
  2. NM_001159552.2NP_001153024.1  minor histocompatibility antigen H13 isoform 3

    See identical proteins and their annotated locations for NP_001153024.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS50753.1
    UniProtKB/TrEMBL
    Q6PGJ8
    Related
    ENSMUSP00000105450.2, ENSMUST00000109825.8
    Conserved Domains (1) summary
    cl01342
    Location:62145
    Peptidase_A22B; Signal peptide peptidase
  3. NM_001159553.2NP_001153025.1  minor histocompatibility antigen H13 isoform 4

    See identical proteins and their annotated locations for NP_001153025.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    UniProtKB/Swiss-Prot
    Q9D8V0
    Conserved Domains (1) summary
    cl01342
    Location:62123
    Peptidase_A22B; Signal peptide peptidase
  4. NM_010376.5NP_034506.1  minor histocompatibility antigen H13 isoform 2

    See identical proteins and their annotated locations for NP_034506.1

    Status: VALIDATED

    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS16896.1
    UniProtKB/Swiss-Prot
    Q9CSK9, Q9D8V0
    Related
    ENSMUSP00000120068.2, ENSMUST00000125366.8
    Conserved Domains (1) summary
    pfam04258
    Location:62350
    Peptidase_A22B; Signal peptide peptidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152511292..152550588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498783.5XP_006498846.1  minor histocompatibility antigen H13 isoform X2

    Related
    ENSMUSP00000078236.4, ENSMUST00000079247.4
    Conserved Domains (1) summary
    pfam04258
    Location:62350
    Peptidase_A22B; Signal peptide peptidase
  2. XM_017315666.3XP_017171155.1  minor histocompatibility antigen H13 isoform X1

    Conserved Domains (1) summary
    cl01342
    Location:50157
    Peptidase_A22B; Signal peptide peptidase

RNA

  1. XR_001780858.3 RNA Sequence

  2. XR_374416.3 RNA Sequence

  3. XR_003950808.2 RNA Sequence