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Conserved domains on  [gi|227116337|ref|NP_001153024|]
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minor histocompatibility antigen H13 isoform 3 [Mus musculus]

Protein Classification

A22B family peptidase( domain architecture ID 3497)

A22B family peptidase similar to Arabidopsis thaliana signal peptide peptidase-like 1, an intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_A22B super family cl01342
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 62-145 1.21e-23

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


The actual alignment was detected with superfamily member pfam04258:

Pssm-ID: 470165  Cd Length: 286  Bit Score: 95.45  E-value: 1.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116337   62 SSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFsqeyINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLL 141
Cdd:pfam04258   1 KSSDDFETITKIHAICFPITASCTLLLLYFFFKSL----LVYVLTIYFCILGIIALAFCLSPFLTRLFFNKCPLKNIKLP 76


                  ....
gi 227116337  142 FTQG 145
Cdd:pfam04258  77 FLPG 80
 
Name Accession Description Interval E-value
Peptidase_A22B pfam04258
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 62-145 1.21e-23

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


Pssm-ID: 282158  Cd Length: 286  Bit Score: 95.45  E-value: 1.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116337   62 SSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFsqeyINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLL 141
Cdd:pfam04258   1 KSSDDFETITKIHAICFPITASCTLLLLYFFFKSL----LVYVLTIYFCILGIIALAFCLSPFLTRLFFNKCPLKNIKLP 76


                  ....
gi 227116337  142 FTQG 145
Cdd:pfam04258  77 FLPG 80
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 66-129 4.65e-09

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 54.95  E-value: 4.65e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227116337    66 MPETITSRDAARFPIIASCTLLGLYLFFKifsqeYINLLLSMYFFVLGILALSHTISPFMNKFF 129
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFK-----YLVIVLVIYFSSLGVLFLYSLLYPLEVFRV 59
 
Name Accession Description Interval E-value
Peptidase_A22B pfam04258
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 62-145 1.21e-23

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


Pssm-ID: 282158  Cd Length: 286  Bit Score: 95.45  E-value: 1.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227116337   62 SSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFsqeyINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLL 141
Cdd:pfam04258   1 KSSDDFETITKIHAICFPITASCTLLLLYFFFKSL----LVYVLTIYFCILGIIALAFCLSPFLTRLFFNKCPLKNIKLP 76


                  ....
gi 227116337  142 FTQG 145
Cdd:pfam04258  77 FLPG 80
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 66-129 4.65e-09

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 54.95  E-value: 4.65e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 227116337    66 MPETITSRDAARFPIIASCTLLGLYLFFKifsqeYINLLLSMYFFVLGILALSHTISPFMNKFF 129
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFK-----YLVIVLVIYFSSLGVLFLYSLLYPLEVFRV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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