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MANEAL mannosidase endo-alpha like [ Homo sapiens (human) ]

Gene ID: 149175, updated on 11-Jun-2021

Summary

Official Symbol
MANEALprovided by HGNC
Official Full Name
mannosidase endo-alpha likeprovided by HGNC
Primary source
HGNC:HGNC:26452
See related
Ensembl:ENSG00000185090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 5.9), thyroid (RPKM 2.3) and 21 other tissues See more
Orthologs
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Genomic context

See MANEAL in Genome Data Viewer
Location:
1p34.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (37793816..37801133)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38259519..38266805)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene valosin containing protein lysine methyltransferase pseudogene Neighboring gene actinin alpha 4 pseudogene 2 Neighboring gene yrdC N6-threonylcarbamoyltransferase domain containing Neighboring gene chromosome 1 open reading frame 122 Neighboring gene metal regulatory transcription factor 1 Neighboring gene ribosomal protein S2 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31434, MGC78681

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycoprotein endo-alpha-1,2-mannosidase-like protein
NP_001026910.1
NP_001106954.1
NP_689709.1
XP_005270567.1
XP_011539090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031740.3NP_001026910.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate frame-shifting splice site in the 3' terminal exon, compared to variant 3. This difference results in a protein (isoform 1) with a shorter, distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AK055996, AL929472, BC077730
    Consensus CDS
    CCDS44111.1
    UniProtKB/Swiss-Prot
    Q5VSG8
    Related
    ENSP00000380755.3, ENST00000397631.7
    Conserved Domains (1) summary
    cl01529
    Location:105249
    GH99_GH71_like; Glycoside hydrolase families 71, 99, and related domains
  2. NM_001113482.2NP_001106954.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001106954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL929472, BC063587, BC077730
    Consensus CDS
    CCDS44110.1
    UniProtKB/Swiss-Prot
    Q5VSG8
    Related
    ENSP00000362136.6, ENST00000373045.11
    Conserved Domains (1) summary
    cd11574
    Location:105446
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase
  3. NM_152496.3NP_689709.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform 2

    See identical proteins and their annotated locations for NP_689709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 3.
    Source sequence(s)
    AK055996
    Consensus CDS
    CCDS426.1
    UniProtKB/Swiss-Prot
    Q5VSG8
    Related
    ENSP00000328770.5, ENST00000329006.5
    Conserved Domains (1) summary
    cd11574
    Location:24224
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    37793816..37801133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270510.3XP_005270567.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X1

    Conserved Domains (1) summary
    cd11574
    Location:105328
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase
  2. XM_011540788.1XP_011539090.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X2

    See identical proteins and their annotated locations for XP_011539090.1

    UniProtKB/Swiss-Prot
    Q5VSG8
    Conserved Domains (1) summary
    cd11574
    Location:24224
    GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase
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