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DCST1 DC-STAMP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 149095, updated on 5-Aug-2018

Summary

Official Symbol
DCST1provided by HGNC
Official Full Name
DC-STAMP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26539
See related
Ensembl:ENSG00000163357 Vega:OTTHUMG00000041314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Biased expression in testis (RPKM 2.9), skin (RPKM 1.8) and 8 other tissues See more
Orthologs

Genomic context

See DCST1 in Genome Data Viewer
Location:
1q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155033806..155050930)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155006256..155023406)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lens epithelial protein Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene DC-STAMP domain containing 2 Neighboring gene DCST1 antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene ephrin A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ADAM15

Homology

Clone Names

  • FLJ32785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DCST1
Names
DC-STAMP domain-containing protein 1
RING-type E3 ubiquitin transferase
NP_001137159.1
NP_689707.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027536.1 RefSeqGene

    Range
    5001..22125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143687.2NP_001137159.1  E3 ubiquitin-protein ligase DCST1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AK057347, AK301876, AK301902, AK301935
    Consensus CDS
    CCDS44235.1
    UniProtKB/Swiss-Prot
    Q5T197
    UniProtKB/TrEMBL
    B4DXB8, B4DXE3
    Related
    ENSP00000387369.2, OTTHUMP00000231880, ENST00000423025.6, OTTHUMT00000387789
    Conserved Domains (1) summary
    pfam07782
    Location:380570
    DC_STAMP; DC-STAMP-like protein
  2. NM_152494.3NP_689707.2  E3 ubiquitin-protein ligase DCST1 isoform 1

    See identical proteins and their annotated locations for NP_689707.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK057347, AK301876, AK301902, AK301935
    Consensus CDS
    CCDS1083.1
    UniProtKB/Swiss-Prot
    Q5T197
    UniProtKB/TrEMBL
    B4DXB8, B4DXE3
    Related
    ENSP00000295542.1, OTTHUMP00000038746, ENST00000295542.5, OTTHUMT00000099006
    Conserved Domains (1) summary
    pfam07782
    Location:405595
    DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    155033806..155050930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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