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ADAM15 ADAM metallopeptidase domain 15 [ Homo sapiens (human) ]

Gene ID: 8751, updated on 5-Aug-2018

Summary

Official Symbol
ADAM15provided by HGNC
Official Full Name
ADAM metallopeptidase domain 15provided by HGNC
Primary source
HGNC:HGNC:193
See related
Ensembl:ENSG00000143537 MIM:605548; Vega:OTTHUMG00000013898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDC15
Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 41.3), esophagus (RPKM 32.4) and 25 other tissues See more
Orthologs

Genomic context

See ADAM15 in Genome Data Viewer
Location:
1q21.3
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (155051272..155062776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155023748..155035252)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene DC-STAMP domain containing 2 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DCST1 antisense RNA 1 Neighboring gene ephrin A4 Neighboring gene ephrin A3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ADAM metallopeptidase domain 15 (ADAM15) by siRNA inhibits HIV-1 replication in MAGI-CCR5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DCST1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
NOT apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cardiac epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to phorbol 13-acetate 12-myristate IDA
Inferred from Direct Assay
more info
PubMed 
collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
immune response to tumor cell IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 15
Names
MDC-15
a disintegrin and metalloproteinase domain 15 (metargidin)
metalloprotease RGD disintegrin protein
metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029667.1 RefSeqGene

    Range
    4987..16491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261464.1NP_001248393.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons in the 3' coding region compared to variant 6. The resulting protein (isoform 7) is shorter compared to isoform 6.
    Source sequence(s)
    AK296925, AL451085, AL691442, BM971880
    Consensus CDS
    CCDS58031.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000432927.1, OTTHUMP00000231578, ENST00000531455.5, OTTHUMT00000387178
    Conserved Domains (5) summary
    smart00050
    Location:440514
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:518659
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:223421
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223423
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:72164
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_001261465.1NP_001248394.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 8 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two alternate in-frame exons in the 3' coding region compared to variant 6. The resulting protein (isoform 8) is shorter compared to isoform 6.
    Source sequence(s)
    AL451085, AL691442, AY560595, BM971880
    Consensus CDS
    CCDS58032.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000357397.3, OTTHUMP00000231576, ENST00000368412.7, OTTHUMT00000387172
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  3. NM_001261466.1NP_001248395.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 9 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the 5' coding region and differs in the 3' coding region and UTR compared to variant 6. The resulting protein (isoform 9) is shorter and has a distinct C-terminus compared to isoform 6.
    Source sequence(s)
    AK297468, AL451085, AL691442, AW290953
    Consensus CDS
    CCDS60282.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000476000.1, OTTHUMP00000273312, ENST00000447332.3, OTTHUMT00000387179
    Conserved Domains (5) summary
    smart00050
    Location:414488
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:492624
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:197395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:197397
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:72138
    Pep_M12B_propep; Reprolysin family propeptide
  4. NM_003815.4NP_003806.3  disintegrin and metalloproteinase domain-containing protein 15 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_003806.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame coding exons compared to variant 6. The resulting isoform (2) lacks an internal region, as compared to the longest isoform (6).
    Source sequence(s)
    AK000667, AL451085, AY518542, BC014566, BM971880, U41767
    Consensus CDS
    CCDS1084.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000271836.6, OTTHUMP00000015780, ENST00000271836.10, OTTHUMT00000038982
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  5. NM_207191.2NP_997074.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_997074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks three exons in the coding region compared to variant 6, one of which causes a translation frameshift. The resulting isoform (1) has a distinct and shorter C-terminus, as compared to the longest isoform (6).
    Source sequence(s)
    AL451085, AY518542, AY560593, BM971880
    Consensus CDS
    CCDS1088.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000353892.4, OTTHUMP00000231575, ENST00000360674.8, OTTHUMT00000387171
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  6. NM_207194.2NP_997077.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_997077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 6. The resulting isoform (3) lacks an internal region, as compared to the longest isoform 6.
    Source sequence(s)
    AL451085, AY518542, AY560593, AY560596, BM971880, U41767
    Consensus CDS
    CCDS1085.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000348227.2, OTTHUMP00000231577, ENST00000355956.6, OTTHUMT00000387173
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  7. NM_207195.2NP_997078.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_997078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame coding exons compared to variant 6. The resulting isoform (4) lacks an internal region, as compared to the longest isoform (6).
    Source sequence(s)
    AL451085, AY518542, AY560593, AY560597, BM971880, U41767
    Consensus CDS
    CCDS1086.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000352226.4, OTTHUMP00000231574, ENST00000359280.8, OTTHUMT00000387170
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  8. NM_207196.2NP_997079.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_997079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternative splice site within the coding region compared to variant 6. The translation frame remains the same. The resulting isoform (5) lacks an amino acid, as compared to the longest isoform (6).
    Source sequence(s)
    AL451085, AY518542, AY560593, AY560598, BM971880, U41767
    Consensus CDS
    CCDS44236.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000403843.2, OTTHUMP00000231573, ENST00000449910.6, OTTHUMT00000387169
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide
  9. NM_207197.2NP_997080.1  disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein

    See identical proteins and their annotated locations for NP_997080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AL451085, AY518542, AY560593, AY560599, BM971880, U41767
    Consensus CDS
    CCDS1087.1
    UniProtKB/Swiss-Prot
    Q13444
    Related
    ENSP00000349436.2, OTTHUMP00000231572, ENST00000356955.6, OTTHUMT00000387168
    Conserved Domains (5) summary
    smart00050
    Location:430504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:213411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:213413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:62154
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. NR_048577.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses two alternate splice sites in 3' exons compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451085, AL691442, AY560600, BM971880
  2. NR_048578.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site in a 3' exon compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451085, AL691442, AY560601, BM971880
    Related
    ENST00000526491.5, OTTHUMT00000387167
  3. NR_048579.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks an exon and uses an alternate splice site in a 3' exon compared to variant 6. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL451085, AL691442, AY576417, BM971880
    Related
    ENST00000529473.5, OTTHUMT00000387166

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    155051272..155062776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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