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Dcst1 DC-STAMP domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 77772, updated on 9-Mar-2023

Summary

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Official Symbol
Dcst1provided by MGI
Official Full Name
DC-STAMP domain containing 1provided by MGI
Primary source
MGI:MGI:1925022
See related
Ensembl:ENSMUSG00000042672 AllianceGenome:MGI:1925022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330106H01Rik
Summary
This gene encodes a transmembrane protein. A similar gene in human has been associated with dendritic cells. [provided by RefSeq, May 2015]
Expression
Biased expression in testis adult (RPKM 31.4), duodenum adult (RPKM 3.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Dcst1 in Genome Data Viewer
Location:
3; 3 F1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89257526..89272560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89350219..89365253, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34118 Neighboring gene ephrin A4 Neighboring gene a disintegrin and metallopeptidase domain 15 (metargidin) Neighboring gene DC-STAMP domain containing 2 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Noda T, et al. Commun Biol, 2022 Apr 7. PMID 35393517, Free PMC Article
  2. Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion. Inoue N, et al. Elife, 2021 Apr 19. PMID 33871360, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
    Title: Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm-egg recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase DCST1
Names
DC-STAMP domain-containing protein 1
RING-type E3 ubiquitin transferase
NP_084250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029974.2 → NP_084250.1  E3 ubiquitin-protein ligase DCST1

    See identical proteins and their annotated locations for NP_084250.1

    Status: REVIEWED

    Source sequence(s)
    AK030269
    Consensus CDS
    CCDS38490.1
    UniProtKB/Swiss-Prot
    Q059Y8
    Related
    ENSMUSP00000065502.7, ENSMUST00000070820.7
    Conserved Domains (1) summary
    pfam07782
    Location:431 → 621
    DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89257526..89272560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q059Y8.1 GenPept UniProtKB/Swiss-Prot:Q059Y8