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SLC30A7 solute carrier family 30 member 7 [ Homo sapiens (human) ]

Gene ID: 148867, updated on 7-Jun-2020

Summary

Official Symbol
SLC30A7provided by HGNC
Official Full Name
solute carrier family 30 member 7provided by HGNC
Primary source
HGNC:HGNC:19306
See related
Ensembl:ENSG00000162695 MIM:611149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT7; ZnT-7; ZnTL2
Summary
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in appendix (RPKM 3.9), thyroid (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See SLC30A7 in Genome Data Viewer
Location:
1p21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (100896090..100996913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101361632..101552821)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene vascular cell adhesion molecule 1 Neighboring gene exostosin like glycosyltransferase 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 68 Neighboring gene diphthamide biosynthesis 5 Neighboring gene uncharacterized LOC102606465 Neighboring gene uncharacterized LOC107985094

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with solute carrier family 30 (zinc transporter), member 7 (SLC30A7; ZNT7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M0368

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sequestering of zinc ion IEA
Inferred from Electronic Annotation
more info
 
zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc transporter 7
Names
solute carrier family 30 (zinc transporter), member 7
zinc transporter ZnT-7
zinc transporter like 2
znt-like transporter 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144884.2NP_001138356.1  zinc transporter 7

    See identical proteins and their annotated locations for NP_001138356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL732465, BX537375, BX648884
    Consensus CDS
    CCDS776.1
    UniProtKB/Swiss-Prot
    Q8NEW0
    Related
    ENSP00000359130.4, ENST00000370112.8
    Conserved Domains (2) summary
    COG1230
    Location:31374
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:48294
    Cation_efflux; Cation efflux family
  2. NM_133496.5NP_598003.2  zinc transporter 7

    See identical proteins and their annotated locations for NP_598003.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AL732465, BC064692, BX648884, DA997188
    Consensus CDS
    CCDS776.1
    UniProtKB/Swiss-Prot
    Q8NEW0
    Related
    ENSP00000350278.4, ENST00000357650.9
    Conserved Domains (2) summary
    COG1230
    Location:31374
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:48294
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    100896090..100996913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000400.2XP_016855889.1  zinc transporter 7 isoform X1

    UniProtKB/Swiss-Prot
    Q8NEW0
    Conserved Domains (2) summary
    COG1230
    Location:31374
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:48294
    Cation_efflux; Cation efflux family
  2. XM_017000401.2XP_016855890.1  zinc transporter 7 isoform X3

  3. XM_011540779.3XP_011539081.1  zinc transporter 7 isoform X2

    Conserved Domains (2) summary
    COG1230
    Location:1304
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:1224
    Cation_efflux; Cation efflux family

RNA

  1. XR_246237.3 RNA Sequence

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