Slc30a7 solute carrier family 30 (zinc transporter), member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a7provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 7provided by MGI
Primary source: MGI:MGI:1913750
See related: Ensembl:ENSMUSG00000054414 AllianceGenome:MGI:1913750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZnT7; ZnT-7; Zntl2; 1810059J10Rik; 2610034N15Rik; 4833428C12Rik
Summary: Enables zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis and zinc ion import into Golgi lumen. Acts upstream of or within zinc ion transport. Located in Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including nervous system and urinary system. Orthologous to human SLC30A7 (solute carrier family 30 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 7.4), limb E14.5 (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 50.16 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (115732622..115801079, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (115938973..116007414, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn[2+] uptake into the Golgi apparatus.
Title: Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn(2+) uptake into the Golgi apparatus.
Loss of znt7 expression is associated with aberrant fatty acid metabolism in skeletal muscle leading to insulin resistance.
Title: Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice.
The results demonstrated that ZnT7 gene silencing downregulated the expression of StAR, P450scc and 3beta-HSD as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells.
Title: A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells.
A role for ZnT7 in adipocyte lipogenesis: reduction of Znt7 expression affects lipid accumulation in adipocytes.
Title: Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activation and glucose uptake.
In Znt7 knockout mice, the body weight and fat deposit was significantly linked to a locus on chromosome 7 ranging from 64.3 to 78.3 Mb.
Title: Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice.
ZnT7 promotes cell survival via two distinct signaling pathways involving activation of the PI3K/Akt-mediated survival pathway and activation of MAPK/ERK pathway.
Title: ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways.
Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance
Title: Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance.
A null-mutation of the Znt7 gene accelerates prostate tumor formation in TRAMP mice.
Title: A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model.
Immunoelectron microscopic study showed that ZNT7 was localized to the membrane of the Golgi apparatus in the somas of the Purkinje cells, Bergmann glial cells, and granule cells throughout the cerebellar cortex.
Title: Golgi apparatus localization of ZNT7 in the mouse cerebellum.
ZNT7 and chelatable zinc were distributed in different cell populations. ZNT7 may be involved in zinc transportation into the Golgi apparatus for protein packaging in the mouse testis
Title: ZNT7 and Zn2+ are present in different cell populations in the mouse testis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a7 (e-PCR), detects polymorphism
- UniSTS:547079

BE115199 (e-PCR)
- UniSTS:261398

NoName (e-PCR)
- UniSTS:234809

AI467242 (e-PCR)
- UniSTS:165292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IC Inferred by Curator more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion import into Golgi lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import into Golgi lumen	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import into Golgi lumen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter 7

Names: solute carrier family 30 member 7; znt-like transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023214.7 → NP_075703.1 zinc transporter 7

See identical proteins and their annotated locations for NP_075703.1

Status: VALIDATED

Source sequence(s)

AC108909, AC131113, AK075802

Consensus CDS

CCDS17783.1

UniProtKB/Swiss-Prot

Q80Y27, Q9JKN1

Related

ENSMUSP00000065254.4, ENSMUST00000067485.4

Conserved Domains (2) summary

COG1230
Location:31 → 376

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:48 → 296

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

115732622..115801079 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163227.1 → XP_036019120.1 zinc transporter 7 isoform X1

Conserved Domains (1) summary

COG1230
Location:31 → 284

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
XM_011240194.2 → XP_011238496.1 zinc transporter 7 isoform X2

Conserved Domains (1) summary

COG1230
Location:31 → 159

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]