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ZNF570 zinc finger protein 570 [ Homo sapiens (human) ]

Gene ID: 148268, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF570provided by HGNC
Official Full Name
zinc finger protein 570provided by HGNC
Primary source
HGNC:HGNC:26416
See related
Ensembl:ENSG00000171827 AllianceGenome:HGNC:26416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 2.3), thyroid (RPKM 1.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF570 in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37467772..37488652)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40269271..40290151)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37958674..37979554)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 527 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:38020876-38021698 Neighboring gene uncharacterized LOC124904708 Neighboring gene ZNF571 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  3. A proximity-dependent biotinylation map of a human cell. Go CD, et al. Nature, 2021 Jul. PMID 34079125
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ30791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 570

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300993.3 → NP_001287922.1  zinc finger protein 570 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008806, AK308252, BM671447, BQ773525
    Consensus CDS
    CCDS74355.1
    UniProtKB/TrEMBL
    K7EP39
    Related
    ENSP00000467218.1, ENST00000586475.5
    Conserved Domains (4) summary
    smart00349
    Location:70 → 130
    KRAB; krueppel associated box
    COG5048
    Location:307 → 572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:388 → 408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:288 → 313
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321991.3 → NP_001308920.1  zinc finger protein 570 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008806, AK055353, BM671447, BP312352
    Consensus CDS
    CCDS12504.1
    UniProtKB/Swiss-Prot
    A1L472, B4DMP1, Q96NI8
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:251 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232 → 257
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001321992.3 → NP_001308921.1  zinc finger protein 570 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008806, BC130425, BM671447
    UniProtKB/Swiss-Prot
    Q96NI8
    Conserved Domains (4) summary
    COG5048
    Location:209 → 474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:190 → 215
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. NM_001321993.3 → NP_001308922.1  zinc finger protein 570 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008806, AK297561, BC130425, BM671447
    UniProtKB/Swiss-Prot
    Q96NI8
    Conserved Domains (3) summary
    COG5048
    Location:48 → 313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:29 → 54
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001321994.3 → NP_001308923.1  zinc finger protein 570 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008806, AK297561, BC130425, BM671447
    UniProtKB/Swiss-Prot
    Q96NI8
    Conserved Domains (3) summary
    COG5048
    Location:48 → 313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:29 → 54
    zf-H2C2_2; Zinc-finger double domain

  6. NM_144694.5 → NP_653295.1  zinc finger protein 570 isoform 2

    See identical proteins and their annotated locations for NP_653295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008806, BC130425, BM671447
    Consensus CDS
    CCDS12504.1
    UniProtKB/Swiss-Prot
    A1L472, B4DMP1, Q96NI8
    Related
    ENSP00000331540.1, ENST00000330173.6
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:251 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:232 → 257
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37467772..37488652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40269271..40290151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96NI8.1 GenPept UniProtKB/Swiss-Prot:Q96NI8

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