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ZNF558 zinc finger protein 558 [ Homo sapiens (human) ]

Gene ID: 148156, updated on 25-Jan-2022

Summary

Official Symbol
ZNF558provided by HGNC
Official Full Name
zinc finger protein 558provided by HGNC
Primary source
HGNC:HGNC:26422
See related
Ensembl:ENSG00000167785 AllianceGenome:HGNC:26422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in endometrium (RPKM 6.2), thyroid (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF558 in Genome Data Viewer
Location:
19p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8806170..8838144, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8916846..8942980, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene actin like 9 Neighboring gene ribosomal protein L23a pseudogene 78 Neighboring gene olfactory receptor family 2 subfamily Z member 1 Neighboring gene methyl-CpG binding domain protein 3 like 1 Neighboring gene mucin 16, cell surface associated Neighboring gene bolA family member 3 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30932

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304350.2NP_001291279.1  zinc finger protein 558 isoform 2

    See identical proteins and their annotated locations for NP_001291279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation from a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC008734, AC012616, AK301664, BC064356, BM728437, DB547630
    UniProtKB/Swiss-Prot
    Q96NG5
    Conserved Domains (3) summary
    COG5048
    Location:91327
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:129
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  2. NM_144693.3NP_653294.1  zinc finger protein 558 isoform 1

    See identical proteins and their annotated locations for NP_653294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008734, AC012616, AK291265, AK307200, BC064356, DB478966, DB547630
    Consensus CDS
    CCDS12208.1
    UniProtKB/Swiss-Prot
    Q96NG5
    Related
    ENSP00000471277.1, ENST00000601372.6
    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8806170..8838144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451393.1XP_024307161.1  zinc finger protein 558 isoform X1

    Related
    ENSP00000301475.1, ENST00000301475.1
    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_024451387.1XP_024307155.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017026370.1XP_016881859.1  zinc finger protein 558 isoform X2

    UniProtKB/Swiss-Prot
    Q96NG5
    Conserved Domains (3) summary
    COG5048
    Location:91327
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:129
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. XM_024451391.1XP_024307159.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024451389.1XP_024307157.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_017026371.1XP_016881860.1  zinc finger protein 558 isoform X2

    UniProtKB/Swiss-Prot
    Q96NG5
    Conserved Domains (3) summary
    COG5048
    Location:91327
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:129
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  7. XM_024451395.1XP_024307163.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_024451394.1XP_024307162.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_024451386.1XP_024307154.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_024451390.1XP_024307158.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_024451388.1XP_024307156.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_017026372.1XP_016881861.1  zinc finger protein 558 isoform X2

    UniProtKB/Swiss-Prot
    Q96NG5
    Conserved Domains (3) summary
    COG5048
    Location:91327
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:129
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  13. XM_024451392.1XP_024307160.1  zinc finger protein 558 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:43100
    KRAB; krueppel associated box
    COG5048
    Location:162398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294314
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_011527703.2XP_011526005.1  zinc finger protein 558 isoform X2

    See identical proteins and their annotated locations for XP_011526005.1

    UniProtKB/Swiss-Prot
    Q96NG5
    Conserved Domains (3) summary
    COG5048
    Location:91327
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:129
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
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