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FAM98C family with sequence similarity 98 member C [ Homo sapiens (human) ]

Gene ID: 147965, updated on 17-Sep-2022

Summary

Official Symbol
FAM98Cprovided by HGNC
Official Full Name
family with sequence similarity 98 member Cprovided by HGNC
Primary source
HGNC:HGNC:27119
See related
Ensembl:ENSG00000130244 AllianceGenome:HGNC:27119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 5.6), stomach (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See FAM98C in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38403093..38409088)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41205269..41211264)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38893733..38899728)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sprouty related EVH1 domain containing 3 Neighboring gene gametogenetin Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ryanodine receptor 1 Neighboring gene uncharacterized LOC124904710 Neighboring gene MAP4K1 antisense RNA 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054925.1 RefSeqGene

    Range
    4970..10961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351675.1NP_001338604.1  protein FAM98C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC036482, BC080606, BC143830
    Consensus CDS
    CCDS86763.1
    Related
    ENSP00000340348.6, ENST00000343358.11
    Conserved Domains (1) summary
    pfam10239
    Location:18252
    DUF2465; Protein of unknown function (DUF2465)
  2. NM_174905.4NP_777565.3  protein FAM98C isoform 1

    See identical proteins and their annotated locations for NP_777565.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005789
    Consensus CDS
    CCDS42562.1
    UniProtKB/Swiss-Prot
    Q17RN3, Q66K45
    Related
    ENSP00000252530.4, ENST00000252530.10
    Conserved Domains (1) summary
    pfam10239
    Location:18334
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38403093..38409088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026354.2XP_016881843.1  protein FAM98C isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41205269..41211264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)