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Lpcat3 lysophosphatidylcholine acyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 14792, updated on 5-Feb-2023

Summary

Official Symbol
Lpcat3provided by MGI
Official Full Name
lysophosphatidylcholine acyltransferase 3provided by MGI
Primary source
MGI:MGI:1315211
See related
Ensembl:ENSMUSG00000004270 AllianceGenome:MGI:1315211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3f; PTG; Lpcat; Lpeat; Lpsat; Oact5; Grcc3f; Lplat5; Mboat5; Moact5
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in several processes, including glycerophospholipid metabolic process; plasma lipoprotein particle assembly; and positive regulation of lipid transport. Acts upstream of or within regulation of plasma lipoprotein particle levels. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; endocrine gland; hemolymphoid system; and liver. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 97.2), testis adult (RPKM 92.5) and 28 other tissues See more
Orthologs
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Genomic context

See Lpcat3 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124639762..124681679)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124663094..124704716)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene complement component 1, r subcomponent B Neighboring gene complement component 1, s subcomponent 2 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene predicted gene, 23547 Neighboring gene microRNA 141 Neighboring gene prohibitin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chylomicron assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylserine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intestinal cholesterol absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sterol regulatory element binding protein cleavage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of plasma lipoprotein particle levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lysophospholipid acyltransferase 5
Names
1-acylglycerophosphoserine O-acyltransferase
LPC acyltransferase 3
O-acyltransferase domain-containing protein 5
lyso-PC acyltransferase 3
lyso-PE acyltransferase
lyso-PS acyltransferase
lysophosphatidylethanolamine acyltransferase
lysophosphatidylserine acyltransferase
NP_660112.1
XP_036021745.1
XP_036021746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145130.3NP_660112.1  lysophospholipid acyltransferase 5

    See identical proteins and their annotated locations for NP_660112.1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS20523.1
    UniProtKB/Swiss-Prot
    Q8BNH6, Q91V01
    UniProtKB/TrEMBL
    A0A8C6HIJ0
    Related
    ENSMUSP00000004381.8, ENSMUST00000004381.14
    Conserved Domains (1) summary
    pfam03062
    Location:126437
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_149320.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  2. NR_176913.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  3. NR_176914.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124639762..124681679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165853.1XP_036021746.1  lysophospholipid acyltransferase 5 isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:2217
    MBOAT; membrane-bound O-acyltransferase family
  2. XM_036165852.1XP_036021745.1  lysophospholipid acyltransferase 5 isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:2217
    MBOAT; membrane-bound O-acyltransferase family

RNA

  1. XR_377423.4 RNA Sequence