LPCAT3 lysophosphatidylcholine acyltransferase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LPCAT3provided by HGNC
Official Full Name: lysophosphatidylcholine acyltransferase 3provided by HGNC
Primary source: HGNC:HGNC:30244
See related: Ensembl:ENSG00000111684 MIM:611950; AllianceGenome:HGNC:30244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5; LPLAT12
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (6976185..7018476, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (6989663..7031946, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (7085347..7125780, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Title: Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
Title: Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.
Title: LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity.
The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism.
Title: The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism.
Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.
Title: Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.
LPCAT3 is depleted in non-alcoholic steatohepatitis and leads to caspase-dependent/caspase-independent cell death.
Title: Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.
Regulation of LPCAT3 expression might be associated with atherosclerotic progression in humans.
Title: Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3.
Title: Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.
Our findings suggest that LPCAT3 plays an important role in M1/M2-macrophage polarization, providing novel potential therapeutic targets for the regulation of immune and inflammatory disorders
Title: Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.
LPCAT3 a key contributor to the human macrophages inflammatory response.
Title: Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1206E (e-PCR)
- UniSTS:44825

PMC156606P1 (e-PCR)
- UniSTS:271408

RH47084 (e-PCR)
- UniSTS:6229

RH80030 (e-PCR)
- UniSTS:87680

G33059 (e-PCR)
- UniSTS:117635

SHGC-33346 (e-PCR)
- UniSTS:73094

RH11325 (e-PCR)
- UniSTS:77219

RH44811 (e-PCR)
- UniSTS:43195

RH26657 (e-PCR)
- UniSTS:86499

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphoserine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 2-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chylomicron assembly	IEA Inferred from Electronic Annotation more info
involved_in chylomicron assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum membrane organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal stem cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intestinal stem cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phosphatidylserine acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine acyl-chain remodeling	TAS Traceable Author Statement more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intestinal cholesterol absorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intestinal cholesterol absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of triglyceride transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of plasma lipoprotein particle levels	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophospholipid acyltransferase 5

Names: 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 5; O-acyltransferase domain-containing protein 5; lyso-PC acyltransferase 3; lyso-PS acyltransferase; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 12; membrane bound O-acyltransferase domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5; putative protein similar to nessy

NP_005759.4

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.