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LPCAT3 lysophosphatidylcholine acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 10162, updated on 1-Aug-2020

Summary

Official Symbol
LPCAT3provided by HGNC
Official Full Name
lysophosphatidylcholine acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:30244
See related
Ensembl:ENSG00000111684 MIM:611950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5
Expression
Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues See more
Orthologs

Genomic context

See LPCAT3 in Genome Data Viewer
Location:
12p13.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6976185..7018508, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7085347..7125842, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MIR200C and MIR141 host gene Neighboring gene microRNA 141 Neighboring gene small Cajal body-specific RNA 12 Neighboring gene prohibitin 2 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene ribosomal protein L37 pseudogene 20 Neighboring gene zinc finger protein 655 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerophosphocholine O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-acylglycerophosphocholine O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysophospholipid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chylomicron assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal stem cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylcholine acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
positive regulation of intestinal cholesterol absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sterol regulatory element binding protein cleavage ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of triglyceride transport ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
very-low-density lipoprotein particle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lysophospholipid acyltransferase 5
Names
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoserine O-acyltransferase
O-acyltransferase (membrane bound) domain containing 5
O-acyltransferase domain-containing protein 5
lyso-PC acyltransferase 3
lyso-PS acyltransferase
lysophosphatidylserine acyltransferase
membrane bound O-acyltransferase domain containing 5
membrane-bound O-acyltransferase domain-containing protein 5
putative protein similar to nessy
NP_005759.4
XP_024304561.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005768.6NP_005759.4  lysophospholipid acyltransferase 5

    See identical proteins and their annotated locations for NP_005759.4

    Status: VALIDATED

    Source sequence(s)
    AU125262, BX648009
    Consensus CDS
    CCDS8572.1
    UniProtKB/Swiss-Prot
    Q6P1A2
    Related
    ENSP00000261407.4, ENST00000261407.9
    Conserved Domains (1) summary
    cl00738
    Location:24487
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6976185..7018508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448793.1XP_024304561.1  lysophospholipid acyltransferase 5 isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:24511
    MBOAT; membrane-bound O-acyltransferase family
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