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Gna14 guanine nucleotide binding protein, alpha 14 [ Mus musculus (house mouse) ]

Gene ID: 14675, updated on 2-Nov-2024

Summary

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Official Symbol
Gna14provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha 14provided by MGI
Primary source
MGI:MGI:95769
See related
Ensembl:ENSMUSG00000024697 AllianceGenome:MGI:95769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg1i
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axial skeleton; gut; metanephros; oocyte; and respiratory system. Orthologous to human GNA14 (G protein subunit alpha 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 20.8), adrenal adult (RPKM 12.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Gna14 in Genome Data Viewer
Location:
19 A; 19 11.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16413031..16590706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16435667..16610818)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha q polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E4270 Neighboring gene microRNA 496b Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:16447604-16447805 Neighboring gene STARR-seq mESC enhancer starr_45659 Neighboring gene STARR-seq mESC enhancer starr_45660 Neighboring gene STARR-seq mESC enhancer starr_45662 Neighboring gene predicted gene, 19312 Neighboring gene STARR-seq mESC enhancer starr_45663 Neighboring gene nuclear import 7 pseudogene Neighboring gene predicted gene, 41811 Neighboring gene STARR-seq mESC enhancer starr_45666 Neighboring gene vacuolar protein sorting 13A Neighboring gene predicted gene, 32256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:16855612-16855721 Neighboring gene STARR-seq mESC enhancer starr_45668 Neighboring gene forkhead box B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. Shindo Y, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18801333
  2. Tumor-Promoting Role of GNA14 in Colon Cancer Development. Park R, et al. Cancers (Basel), 2023 Sep 15. PMID 37760541, Free PMC Article
  3. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Wilkie TM, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946421, Free PMC Article
  4. Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells. Xu X, et al. J Biol Chem, 1998 Oct 16. PMID 9765251
  5. Loss of gq/11 genes does not abolish melanopsin phototransduction. Chew KS, et al. PLoS One, 2014. PMID 24870805, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest the important roles of G alpha14 in sweet/umami taste signal transduction in the posterior region of the tongue.
    Title: G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein subunit alpha-14
Names
G-protein subunit alpha-14
g alpha-14
heterotrimeric guanine nucleotide-binding protein 1i

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008137.4 → NP_032163.3  guanine nucleotide-binding protein subunit alpha-14

    See identical proteins and their annotated locations for NP_032163.3

    Status: VALIDATED

    Source sequence(s)
    AK035320, AK085444, BY034514, CK128401
    Consensus CDS
    CCDS29685.1
    UniProtKB/Swiss-Prot
    P30677, Q8R2X9
    UniProtKB/TrEMBL
    Q8C3M7
    Related
    ENSMUSP00000025602.3, ENSMUST00000025602.4
    Conserved Domains (2) summary
    cd00066
    Location:36 → 349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:16 → 353
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    16413031..16590706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161435.1 → XP_036017328.1  guanine nucleotide-binding protein subunit alpha-14 isoform X1

    Conserved Domains (1) summary
    cd00066
    Location:2 → 185
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30677.2 GenPept UniProtKB/Swiss-Prot:P30677

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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