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GNA14 G protein subunit alpha 14 [ Homo sapiens (human) ]

Gene ID: 9630, updated on 1-Jun-2020

Summary

Official Symbol
GNA14provided by HGNC
Official Full Name
G protein subunit alpha 14provided by HGNC
Primary source
HGNC:HGNC:4382
See related
Ensembl:ENSG00000156049 MIM:604397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Expression
Broad expression in thyroid (RPKM 10.6), endometrium (RPKM 6.0) and 22 other tissues See more
Orthologs

Genomic context

See GNA14 in Genome Data Viewer
Location:
9q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (77423079..77648322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (80037995..80263232, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene replication factor C 5 pseudogene 1 Neighboring gene VPS13A antisense RNA 1 Neighboring gene vacuolar protein sorting 13 homolog A Neighboring gene GNA14 antisense RNA 1 Neighboring gene nuclear transport factor 2 pseudogene 3 Neighboring gene RNA, U6 small nuclear 1303, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6496 Neighboring gene G protein subunit alpha q Neighboring gene uncharacterized LOC107987081

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-14
Names
g alpha-14
guanine nucleotide binding protein (G protein), alpha 14
guanine nucleotide-binding protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004297.4NP_004288.1  guanine nucleotide-binding protein subunit alpha-14

    See identical proteins and their annotated locations for NP_004288.1

    Status: REVIEWED

    Source sequence(s)
    AI263118, AI629022, AK312460, AL158159, AL355535, BC027886
    Consensus CDS
    CCDS6657.1
    UniProtKB/Swiss-Prot
    O95837
    Related
    ENSP00000365807.4, ENST00000341700.7
    Conserved Domains (2) summary
    cd00066
    Location:36349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:16353
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    77423079..77648322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015341.1XP_016870830.1  guanine nucleotide-binding protein subunit alpha-14 isoform X1

  2. XM_011519224.1XP_011517526.1  guanine nucleotide-binding protein subunit alpha-14 isoform X2

    Conserved Domains (2) summary
    cd00066
    Location:2231
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:1235
    G_alpha; G protein alpha subunit
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