Fut7 fucosyltransferase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut7provided by MGI
Official Full Name: fucosyltransferase 7provided by MGI
Primary source: MGI:MGI:107692
See related: Ensembl:ENSMUSG00000036587 AllianceGenome:MGI:107692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FTVII; Fuc-TVII; FucT-VII
Summary: Predicted to enable 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in leukocyte migration; regulation of cellular extravasation; and regulation of type IV hypersensitivity. Acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and leukocyte migration involved in immune response. Predicted to be located in trans-Golgi network. Orthologous to human FUT7 (fucosyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 2.7), spleen adult (RPKM 0.9) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.25 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25312363..25316386)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25422351..25426374)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The DNA demethylation within the fut7 gene controls selectin ligand expression in mice, including the inducible topographic commitment of T cells for skin and inflamed sites.
Title: Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.
Cloning of an intragenic region spanning a 1kb region upstream of exon 4 into an enhancer-containing vector indeed elicited fut7 promoter activity in cd4 positive T cells.
Title: Identification of two regulatory elements controlling Fucosyltransferase 7 transcription in murine CD4+ T cells.
These results demonstrate that all genetic information essential for appropriate and selective expression of Fut7 in diverse cell types and in response to distinct developmental signals is contained within this comparatively small genetic region.
Title: Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus.
alpha(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.
Title: α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.
Functional PSGL-1 generated by basophil FT-IV/VII and its subsequent binding to L-selectin could be one of the essential steps required for initial basophil recruitment and the development of IgE-chronic allergic inflammation in mice.
Title: α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.
striking differences between the requirement of FucT-VII and C2GlcNAcT-I for Ligands for E-selectin and P-selectin expression in CD4+ T cells.
Title: Differential regulation and impact of fucosyltransferase VII and core 2 β1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4+ T cells.
Loss of the barrier protective molecule TFF3 leads to a profound increase in susceptibility to DSS-induced colitis, and this can be abrogated by reducing Fuc-TVII-dependent leukocyte recruitment.
Title: Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
a deficiency in Fuc-TVII, and in a more pronounced fashion, a combined deficiency in both Fuc-TIV and Fuc-TVII, leads to accelerated death following M. tuberculosis infection
Title: Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.
Keratan sulfate sulfotransferase competes with FucT-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation.
Title: Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing.
FucT-VII is an important pathophysiologic mediator of renal ischemia reperfusion injury, structural damage, and neutrophil infiltration postischemia.
Title: Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

UniSTS:224625 (e-PCR)
- UniSTS:224625

AI853193 (e-PCR)
- UniSTS:178581

NoName (e-PCR)
- UniSTS:489188

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration into lymph node	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration into lymphoid organs	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte adhesion to vascular endothelial cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of type IV hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-(1,3)-fucosyltransferase 7

Names: fucosyltransferase VII; galactoside 3-L-fucosyltransferase

NP_001170837.1

EC 2.4.1.-

NP_001170838.1

EC 2.4.1.-

NP_001276382.1

EC 2.4.1.-

NP_001276383.1

EC 2.4.1.-

NP_001276384.1

EC 2.4.1.-

NP_001276385.1

EC 2.4.1.-

NP_038552.1

EC 2.4.1.-

XP_006497765.1

EC 2.4.1.-

XP_006497767.1

EC 2.4.1.-

XP_011237324.1

EC 2.4.1.-

XP_036014219.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177366.1 → NP_001170837.1 alpha-(1,3)-fucosyltransferase 7 isoform b

See identical proteins and their annotated locations for NP_001170837.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (b).

Source sequence(s)

AL732557

Consensus CDS

CCDS50530.1

UniProtKB/Swiss-Prot

Q0VGH5, Q11131

UniProtKB/TrEMBL

E2D0W5

Related

ENSMUSP00000097895.5, ENSMUST00000100320.5

Conserved Domains (2) summary

pfam00852
Location:216 → 384

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:91 → 201

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_001177367.1 → NP_001170838.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_001170838.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Related

ENSMUSP00000109917.3, ENSMUST00000114278.9

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_001289453.1 → NP_001276382.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_001276382.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_001289454.1 → NP_001276383.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_001276383.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_001289455.1 → NP_001276384.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_001276384.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_001289456.1 → NP_001276385.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_001276385.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal
NM_013524.3 → NP_038552.1 alpha-(1,3)-fucosyltransferase 7 isoform a

See identical proteins and their annotated locations for NP_038552.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6 and 7 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform b.

Source sequence(s)

AL732557

Consensus CDS

CCDS15772.1

UniProtKB/TrEMBL

Q3SWS0

Related

ENSMUSP00000039985.6, ENSMUST00000041654.6

Conserved Domains (2) summary

pfam00852
Location:169 → 337

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:44 → 154

Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25312363..25316386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158326.1 → XP_036014219.1 alpha-(1,3)-fucosyltransferase 7 isoform X3

Conserved Domains (2) summary

pfam00852
Location:256 → 424

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:131 → 241

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_011239022.1 → XP_011237324.1 alpha-(1,3)-fucosyltransferase 7 isoform X1

Conserved Domains (2) summary

pfam00852
Location:265 → 433

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:140 → 250

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_006497702.2 → XP_006497765.1 alpha-(1,3)-fucosyltransferase 7 isoform X2

Conserved Domains (2) summary

pfam00852
Location:261 → 429

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:136 → 246

Glyco_tran_10_N; Fucosyltransferase, N-terminal
XM_006497704.1 → XP_006497767.1 alpha-(1,3)-fucosyltransferase 7 isoform X4

See identical proteins and their annotated locations for XP_006497767.1

UniProtKB/Swiss-Prot

Q0VGH5, Q11131

UniProtKB/TrEMBL

E2D0W5

Conserved Domains (2) summary

pfam00852
Location:216 → 384

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:91 → 201

Glyco_tran_10_N; Fucosyltransferase, N-terminal