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FUT7 fucosyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 2529, updated on 13-Mar-2020

Summary

Official Symbol
FUT7provided by HGNC
Official Full Name
fucosyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4018
See related
Ensembl:ENSG00000180549 MIM:602030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FucT-VII
Summary
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 1.7), spleen (RPKM 1.5) and 12 other tissues See more
Orthologs

Genomic context

See FUT7 in Genome Data Viewer
Location:
9q34.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137030174..137032088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139924626..139927292, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 3 Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene chromosome 9 open reading frame 139 Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene uncharacterized LOC105376327 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NPDC1

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
L-fucose catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration involved in immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphocyte migration into lymphoid organs IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neutrophil extravasation IEA
Inferred from Electronic Annotation
more info
 
regulation of type IV hypersensitivity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-(1,3)-fucosyltransferase 7
Names
fuc-TVII
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
fucosyltransferase VII
galactoside 3-L-fucosyltransferase
selectin-ligand synthase
NP_004470.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007527.1 RefSeqGene

    Range
    5753..7667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004479.4NP_004470.1  alpha-(1,3)-fucosyltransferase 7

    See identical proteins and their annotated locations for NP_004470.1

    Status: REVIEWED

    Source sequence(s)
    AL807752
    Consensus CDS
    CCDS7022.1
    UniProtKB/Swiss-Prot
    Q11130
    Related
    ENSP00000318142.6, ENST00000314412.7
    Conserved Domains (2) summary
    pfam00852
    Location:169337
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:44154
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137030174..137032088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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