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J Exp Med. 2008 Jul 7;205(7):1559-65. doi: 10.1084/jem.20072594. Epub 2008 Jun 23.

Foxp3+ regulatory T cells maintain immune homeostasis in the skin.

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  • 1Benaroya Research Institute, Seattle, WA 98101, USA.

Abstract

Cutaneous immune responses must be tightly controlled to prevent unwanted inflammation in response to innocuous antigens, while maintaining the ability to combat skin-tropic pathogens. Foxp3(+) regulatory T (T reg) cells are potent immune regulators and are found at high frequency in both human and mouse skin. Although T reg cells migrate to the skin and can dampen immune responses during experimentally induced inflammation or infection, the importance of cutaneous T reg cells for maintaining normal immune homeostasis in the skin has not been addressed. To selectively block T reg cell function in the skin, we restored the T reg cell compartment in Foxp3-deficient scurfy mice with cells whose ability to migrate to the skin was impaired because of targeted mutation of alpha-1,3-fucosyltransferase VII (Fut7). Although Fut7-deficient T reg cells were present at normal frequency and could function in all other tissues examined, these animals rapidly developed severe cutaneous inflammation. Thus, skin-resident T reg cell are essential for maintaining normal immune homeostasis at this site.

PMID:
18573908
PMCID:
PMC2442633
DOI:
10.1084/jem.20072594
[PubMed - indexed for MEDLINE]
Free PMC Article
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