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Fkbp10 FK506 binding protein 10 [ Mus musculus (house mouse) ]

Gene ID: 14230, updated on 26-Sep-2022

Summary

Official Symbol
Fkbp10provided by MGI
Official Full Name
FK506 binding protein 10provided by MGI
Primary source
MGI:MGI:104769
See related
Ensembl:ENSMUSG00000001555 AllianceGenome:MGI:104769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fkbp6; FKBP65; Fkbprp; FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs
Summary
Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within several processes, including aorta morphogenesis; extracellular matrix organization; and peptidyl-amino acid modification. Located in endoplasmic reticulum; membrane; and mitochondrial intermembrane space. Is expressed in several structures, including connective tissue; intestine epithelium; lung; metanephros; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 89.8), ovary adult (RPKM 79.7) and 18 other tissues See more
Orthologs
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Genomic context

See Fkbp10 in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100306520..100315666)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100415694..100424840)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12348 Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic) Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10 Neighboring gene kelch-like 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP10
Names
65 kDa FK506-binding protein
65 kDa FKBP
FK506 binding protein 6 (65 kDa)
PPIase FKBP10
immunophilin FKBP65
rotamase
NP_001156953.1
NP_034351.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163481.1NP_001156953.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AI846779, AL590968
    UniProtKB/TrEMBL
    Q3UNJ3
    Conserved Domains (3) summary
    cd00051
    Location:504565
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:54146
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:503566
    EF-hand_7; EF-hand domain pair
  2. NM_010221.2NP_034351.2  peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034351.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI846779, AK019446, AL590968, BY311176
    Consensus CDS
    CCDS25422.1
    UniProtKB/Swiss-Prot
    Q61576, Q8VHI1
    Related
    ENSMUSP00000001595.4, ENSMUST00000001595.10
    Conserved Domains (3) summary
    cd00051
    Location:505566
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:54146
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:504567
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100306520..100315666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)