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FKBP10 FKBP prolyl isomerase 10 [ Homo sapiens (human) ]

Gene ID: 60681, updated on 7-Jun-2020

Summary

Official Symbol
FKBP10provided by HGNC
Official Full Name
FKBP prolyl isomerase 10provided by HGNC
Primary source
HGNC:HGNC:18169
See related
Ensembl:ENSG00000141756 MIM:607063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OI6; OI11; BRKS1; FKBP65; PPIASE; hFKBP65
Summary
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in placenta (RPKM 31.0), endometrium (RPKM 25.7) and 22 other tissues See more
Orthologs

Genomic context

See FKBP10 in Genome Data Viewer
Location:
17q21.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41812938..41823215)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39968962..39979469)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.2540 Neighboring gene prolyl 3-hydroxylase family member 4 (inactive) Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch like family member 10 Neighboring gene kelch like family member 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20683, FLJ22041, FLJ23833

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FK506 binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP10
Names
65 kDa FK506-binding protein
65 kDa FKBP
FK506 binding protein 10, 65 kDa
FK506-binding protein 10
FKBP-10
FKBP-65
PPIase FKBP10
immunophilin FKBP65
rotamase
NP_068758.3
XP_011523401.1
XP_011523402.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015860.1 RefSeqGene

    Range
    5001..15508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_12

mRNA and Protein(s)

  1. NM_021939.4NP_068758.3  peptidyl-prolyl cis-trans isomerase FKBP10 precursor

    See identical proteins and their annotated locations for NP_068758.3

    Status: REVIEWED

    Source sequence(s)
    AF337909, AK092708, AL832985
    Consensus CDS
    CCDS11409.1
    UniProtKB/Swiss-Prot
    Q96AY3
    UniProtKB/TrEMBL
    A0A024R1W3, Q658U4, Q8NAG5
    Related
    ENSP00000317232.4, ENST00000321562.9
    Conserved Domains (3) summary
    cd00051
    Location:506567
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:55147
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:504568
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41812938..41823215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525099.3XP_011523401.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X1

    Conserved Domains (3) summary
    cd00051
    Location:525586
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:55147
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:523587
    EF-hand_7; EF-hand domain pair
  2. XM_011525100.2XP_011523402.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X2

    Conserved Domains (3) summary
    cd00051
    Location:434495
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:76168
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:432496
    EF-hand_7; EF-hand domain pair
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