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Ccn2 cellular communication network factor 2 [ Mus musculus (house mouse) ]

Gene ID: 14219, updated on 3-Oct-2021

Summary

Official Symbol
Ccn2provided by MGI
Official Full Name
cellular communication network factor 2provided by MGI
Primary source
MGI:MGI:95537
See related
Ensembl:ENSMUSG00000019997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccn; Fis; Ctgf; Hcs2; Hcs24; Fisp12; fisp-12
Expression
Broad expression in lung adult (RPKM 127.1), ovary adult (RPKM 111.5) and 19 other tissues See more
Orthologs
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Genomic context

See Ccn2 in Genome Data Viewer
Location:
10 A4; 10 11.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24471340..24474581)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24595442..24598683)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (24315248..24318489)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15270 Neighboring gene predicted gene, 40615 Neighboring gene predicted gene, 36089 Neighboring gene predicted gene 6893 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage condensation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within connective tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytosolic calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCN family member 2
Names
Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
cellular communication network factor 1
fibroblast inducible secreated protein
fibroblast inducible secreted protein
hypertrophic chondrocyte-specific gene product 24
hypertrophic chondrocyte-specific protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010217.2NP_034347.2  CCN family member 2 precursor

    See identical proteins and their annotated locations for NP_034347.2

    Status: VALIDATED

    Source sequence(s)
    BQ031485, BQ892143, BQ917383, CB317714, CJ055589, CJ159336
    Consensus CDS
    CCDS23751.1
    UniProtKB/Swiss-Prot
    P29268
    Related
    ENSMUSP00000020171.6, ENSMUST00000020171.12
    Conserved Domains (4) summary
    smart00209
    Location:201242
    TSP1; Thrombospondin type 1 repeats
    smart00214
    Location:102161
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:4081
    IGFBP; Insulin-like growth factor binding protein
    cl21545
    Location:252344
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    24471340..24474581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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