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CCN2 cellular communication network factor 2 [ Homo sapiens (human) ]

Gene ID: 1490, updated on 3-Jun-2024

Summary

Official Symbol
CCN2provided by HGNC
Official Full Name
cellular communication network factor 2provided by HGNC
Primary source
HGNC:HGNC:2500
See related
Ensembl:ENSG00000118523 MIM:121009; AllianceGenome:HGNC:2500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTGF; NOV2; HCS24; IBP-8; IGFBP8
Summary
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
Expression
Broad expression in spleen (RPKM 355.2), gall bladder (RPKM 303.1) and 21 other tissues See more
Orthologs
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Genomic context

See CCN2 in Genome Data Viewer
Location:
6q23.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (131948176..131951372, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133143212..133146410, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132269316..132272512, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit B pseudogene Neighboring gene RN7SK pseudogene 245 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:132180698-132181244 Neighboring gene HNF4 motif-containing MPRA enhancer 74 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132222462-132223015 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:132223016-132223568 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132228019-132228545 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132228546-132229072 Neighboring gene Sharpr-MPRA regulatory region 1543 Neighboring gene CCN2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2799 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132324214-132325413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25069 Neighboring gene microRNA 548aj-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132453077-132454276 Neighboring gene long intergenic non-protein coding RNA 1013

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102839

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin-like growth factor binding TAS
Traceable Author Statement
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cartilage condensation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development TAS
Traceable Author Statement
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
CCN family member 2
Names
IGF-binding protein 8
connective tissue growth factor
hypertrophic chondrocyte-specific protein 24
insulin-like growth factor-binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016131.2 RefSeqGene

    Range
    5000..8196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001901.4NP_001892.2  CCN family member 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL354866
    Consensus CDS
    CCDS5151.1
    UniProtKB/Swiss-Prot
    E1P578, P29279, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
    UniProtKB/TrEMBL
    Q5M8T4
    Related
    ENSP00000356954.3, ENST00000367976.4
    Conserved Domains (4) summary
    pfam00093
    Location:103163
    VWC; von Willebrand factor type C domain
    pfam00219
    Location:2982
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:199242
    TSP1_CCN; CCN3 Nov like TSP1 domain
    cl21545
    Location:253345
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    131948176..131951372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133143212..133146410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)