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Mpzl2 myelin protein zero-like 2 [ Mus musculus (house mouse) ]

Gene ID: 14012, updated on 2-Nov-2024

Summary

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Official Symbol
Mpzl2provided by MGI
Official Full Name
myelin protein zero-like 2provided by MGI
Primary source
MGI:MGI:1289160
See related
Ensembl:ENSMUSG00000032092 AllianceGenome:MGI:1289160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eva; Eva1
Summary
Acts upstream of or within T cell differentiation in thymus and cell-cell adhesion. Located in plasma membrane. Is expressed in several structures, including branchial arch; epithelium; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 111. Orthologous to human MPZL2 (myelin protein zero like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 17.0), placenta adult (RPKM 12.4) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Mpzl2 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44951595..44965341)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45042344..45054043)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44804746-44804978 Neighboring gene CD3 antigen, delta polypeptide Neighboring gene CD3 antigen, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_23989 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44849180-44849480 Neighboring gene STARR-seq mESC enhancer starr_23990 Neighboring gene myelin protein zero-like 3 Neighboring gene junction adhesion molecule like Neighboring gene predicted gene 10684

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of expansion of CD11c(+) B cells and anti-viral immunity by epithelial V-like antigen. Dungan M, et al. Immunobiology, 2020 Mar. PMID 31818507
  2. Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis. Wright E, et al. PLoS One, 2013. PMID 23951051, Free PMC Article
  3. A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes. Garabatos N, et al. Monoclon Antib Immunodiagn Immunother, 2014 Oct. PMID 25357997, Free PMC Article
  4. MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse. Wesdorp M, et al. Am J Hum Genet, 2018 Jul 5. PMID 29961571, Free PMC Article
  5. Epithelial V-like antigen regulates permeability of the blood-CSF barrier. Chatterjee G, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18498762, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that Mpzl2 is expressed in mouse inner ear, and the protein localizes in the auditory inner and outer hair cells, with an asymmetric subcellular localization. We thus present MPZL2 as a novel gene associated with sensorineural hearing loss.
    Title: MPZL2 is a novel gene associated with autosomal recessive nonsyndromic moderate hearing loss.
  2. EVA deficiency results in increased experimental autoimmune encephalomyelitis disease severity. EVA-knockout Mice have normal immune system development and choroid plexus morphology.
    Title: Epithelial V-like antigen mediates efficacy of anti-alpha₄ integrin treatment in a mouse model of multiple sclerosis.
  3. modulation of Eva1 expression in thymocytes is crucial for lymphocyte physiological developmental progression and stromal differentiation
    Title: Lymphoid EVA1 expression is required for DN1-DN3 thymocytes transition.
  4. These results suggest that EVA expressed in choroid plexus cells may regulate the permeability of the blood-CSF barrier.
    Title: Epithelial V-like antigen regulates permeability of the blood-CSF barrier.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myelin protein zero-like protein 2
Names
epithelial V-like antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357727.1 → NP_001344656.1  myelin protein zero-like protein 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC122305
    Consensus CDS
    CCDS23126.1
    UniProtKB/Swiss-Prot
    O70255
    UniProtKB/TrEMBL
    F6RG10, Q3TLS6
    Conserved Domains (1) summary
    cd05880
    Location:28 → 142
    Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

  2. NM_007962.4 → NP_031988.2  myelin protein zero-like protein 2 precursor

    See identical proteins and their annotated locations for NP_031988.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK032788, AK167263, BY230064, BY387940
    Consensus CDS
    CCDS23126.1
    UniProtKB/Swiss-Prot
    O70255
    UniProtKB/TrEMBL
    F6RG10, Q3TLS6
    Related
    ENSMUSP00000034600.5, ENSMUST00000034600.5
    Conserved Domains (1) summary
    cd05880
    Location:28 → 142
    Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44951595..44965341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154609.1 → XP_036010502.1  myelin protein zero-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A1L1STN6
    Related
    ENSMUSP00000150395.2, ENSMUST00000217097.2
    Conserved Domains (2) summary
    cd00096
    Location:2 → 6
    Ig; Ig strand C" [structural motif]
    cl11960
    Location:2 → 62
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70255.1 GenPept UniProtKB/Swiss-Prot:O70255

Gene LinkOut

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