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MPZL2 myelin protein zero like 2 [ Homo sapiens (human) ]

Gene ID: 10205, updated on 7-Jun-2020

Summary

Official Symbol
MPZL2provided by HGNC
Official Full Name
myelin protein zero like 2provided by HGNC
Primary source
HGNC:HGNC:3496
See related
Ensembl:ENSG00000149573 MIM:604873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVA; EVA1; DFNB111
Summary
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in esophagus (RPKM 92.3), urinary bladder (RPKM 53.8) and 14 other tissues See more
Orthologs

Genomic context

See MPZL2 in Genome Data Viewer
Location:
11q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118253416..118264536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118124131..118135251, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule like Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 18 Neighboring gene myelin protein zero like 3 Neighboring gene Sharpr-MPRA regulatory region 14251 Neighboring gene CD3e molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myelin protein zero-like protein 2
Names
epithelial V-like antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005797.4NP_005788.1  myelin protein zero-like protein 2 precursor

    See identical proteins and their annotated locations for NP_005788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF275945, AW073724, DA163069
    Consensus CDS
    CCDS8393.1
    UniProtKB/Swiss-Prot
    O60487
    UniProtKB/TrEMBL
    A0A024R3K1
    Related
    ENSP00000278937.2, ENST00000278937.7
    Conserved Domains (1) summary
    cd05880
    Location:28142
    Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)
  2. NM_144765.2NP_658911.1  myelin protein zero-like protein 2 precursor

    See identical proteins and their annotated locations for NP_658911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1 and is the shorter transcript.
    Source sequence(s)
    BC017774, DA163069
    Consensus CDS
    CCDS8393.1
    UniProtKB/Swiss-Prot
    O60487
    UniProtKB/TrEMBL
    A0A024R3K1
    Related
    ENSP00000408362.2, ENST00000438295.2
    Conserved Domains (1) summary
    cd05880
    Location:28142
    Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118253416..118264536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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