Format

Send to:

Choose Destination

CRP C-reactive protein [ Homo sapiens (human) ]

Gene ID: 1401, updated on 20-Jun-2021

Summary

Official Symbol
CRPprovided by HGNC
Official Full Name
C-reactive proteinprovided by HGNC
Primary source
HGNC:HGNC:2367
See related
Ensembl:ENSG00000132693 MIM:123260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTX1
Summary
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Restricted expression toward liver (RPKM 456.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CRP in Genome Data Viewer
Location:
1q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (159712289..159714589, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159682079..159684379, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily J member 6 pseudogene Neighboring gene C-reactive protein pseudogene 1 Neighboring gene ribosomal protein L27 pseudogene 2 Neighboring gene uncharacterized LOC101928264

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
GeneReviews: Not available
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
GeneReviews: Not available
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
GeneReviews: Not available
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.
GeneReviews: Not available
Common Variants in the CRP Promoter are Associated with a High C-Reactive Protein Level in Kawasaki Disease.
GeneReviews: Not available
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
GeneReviews: Not available
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
GeneReviews: Not available
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
GeneReviews: Not available
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
GeneReviews: Not available
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
GeneReviews: Not available
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
GeneReviews: Not available
Genome-wide association with select biomarker traits in the Framingham Heart Study.
GeneReviews: Not available
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
GeneReviews: Not available
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
GeneReviews: Not available
New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
GeneReviews: Not available
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The dimeric pentamers of CRP are stabilized by two zinc ions trapped within a cleft of the effector face of CRP in the presence of HIV-1 Tat protein PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88244, MGC149895

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables choline binding TAS
Traceable Author Statement
more info
PubMed 
enables complement component C1q complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement component C1q complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables virion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in acute-phase response TAS
Traceable Author Statement
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation by host of viral process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in opsonization TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-reactive protein
Names
C-reactive protein, pentraxin-related
pentraxin 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013007.1 RefSeqGene

    Range
    5001..7301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000567.3NP_000558.2  C-reactive protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_000558.2

    Status: REVIEWED

    Source sequence(s)
    AI609949, BG533281, BG618967, X56214, X56692
    Consensus CDS
    CCDS30911.1
    UniProtKB/Swiss-Prot
    P02741
    Related
    ENSP00000255030.5, ENST00000255030.9
    Conserved Domains (1) summary
    pfam00354
    Location:25220
    Pentaxin; Pentaxin family
  2. NM_001329057.2NP_001315986.1  C-reactive protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AI609949, AK289443, BC070257, BG618397
    Consensus CDS
    CCDS30911.1
    UniProtKB/Swiss-Prot
    P02741
    Conserved Domains (1) summary
    pfam00354
    Location:25220
    Pentaxin; Pentaxin family
  3. NM_001329058.2NP_001315987.1  C-reactive protein isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AI609949, AL445528, BC020766
    Consensus CDS
    CCDS86024.1
    UniProtKB/Swiss-Prot
    P02741
    Related
    ENSP00000357093.1, ENST00000368112.5
    Conserved Domains (1) summary
    cl22861
    Location:1966
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  4. NM_001382703.1NP_001369632.1  C-reactive protein isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL445528
    Related
    ENSP00000357091.1, ENST00000368110.1
    Conserved Domains (1) summary
    cl22861
    Location:19102
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    159712289..159714589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center