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CRP C-reactive protein [ Homo sapiens (human) ]

Gene ID: 1401, updated on 14-Jun-2018
Official Symbol
CRPprovided by HGNC
Official Full Name
C-reactive proteinprovided by HGNC
Primary source
HGNC:HGNC:2367
See related
Ensembl:ENSG00000132693 MIM:123260; Vega:OTTHUMG00000035344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTX1
Summary
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward liver (RPKM 456.5) See more
Orthologs
See CRP in Genome Data Viewer
Location:
1q23.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (159712289..159714589, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159682079..159684396, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily J member 6 pseudogene Neighboring gene C-reactive protein pseudogene 1 Neighboring gene ribosomal protein L27 pseudogene 2 Neighboring gene uncharacterized LOC101928264

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.
NHGRI GWA Catalog
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
NHGRI GWA Catalog
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
NHGRI GWA Catalog
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.
NHGRI GWA Catalog
Common Variants in the CRP Promoter are Associated with a High C-Reactive Protein Level in Kawasaki Disease.
NHGRI GWA Catalog
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
NHGRI GWA Catalog
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
NHGRI GWA Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
NHGRI GWA Catalog
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
NHGRI GWA Catalog
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.
NHGRI GWA Catalog
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
NHGRI GWA Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
NHGRI GWA Catalog
New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
NHGRI GWA Catalog
Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat The dimeric pentamers of CRP are stabilized by two zinc ions trapped within a cleft of the effector face of CRP in the presence of HIV-1 Tat protein PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC88244, MGC149895

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
choline binding TAS
Traceable Author Statement
more info
PubMed 
complement component C1q binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement component C1q binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT virion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
C-reactive protein
Names
C-reactive protein, pentraxin-related
pentraxin 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013007.1 RefSeqGene

    Range
    5001..7301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000567.2NP_000558.2  C-reactive protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_000558.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI609949, BG533281, BG618967, X56214, X56692
    Consensus CDS
    CCDS30911.1
    UniProtKB/Swiss-Prot
    P02741
    Related
    ENSP00000255030.5, OTTHUMP00000033307, ENST00000255030.9, OTTHUMT00000085553
    Conserved Domains (1) summary
    pfam00354
    Location:25220
    Pentaxin; Pentaxin family
  2. NM_001329057.1NP_001315986.1  C-reactive protein isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI609949, AK289443, BC070257, BG618397
    Consensus CDS
    CCDS30911.1
    UniProtKB/Swiss-Prot
    P02741
    Conserved Domains (1) summary
    pfam00354
    Location:25220
    Pentaxin; Pentaxin family
  3. NM_001329058.1NP_001315987.1  C-reactive protein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal intron compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI609949, AL445528, BC020766
    Consensus CDS
    CCDS86024.1
    UniProtKB/Swiss-Prot
    P02741
    Related
    ENSP00000357093.1, ENST00000368112.5
    Conserved Domains (1) summary
    cl22861
    Location:1966
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    159712289..159714589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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