Format

Send to:

Choose Destination

DGKK diacylglycerol kinase kappa [ Homo sapiens (human) ]

Gene ID: 139189, updated on 8-Jul-2021

Summary

Official Symbol
DGKKprovided by HGNC
Official Full Name
diacylglycerol kinase kappaprovided by HGNC
Primary source
HGNC:HGNC:32395
See related
Ensembl:ENSG00000274588 MIM:300837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Expression
Biased expression in adrenal (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DGKK in Genome Data Viewer
Location:
Xp11.22
Exon count:
28
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (50365409..50470851, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (50108408..50213824, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 4 Neighboring gene cyclin B3 Neighboring gene shroom family member 4 Neighboring gene RNA, U6 small nuclear 935, pseudogene Neighboring gene H3 histone pseudogene 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants in DGKK are strongly associated with risk of hypospadias.
GeneReviews: Not available
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase kappa
Names
142 kDa diacylglycerol kinase
DAG kinase kappa
DGK-kappa
diglyceride kinase kappa
NP_001013764.1
XP_016884757.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033143.2 RefSeqGene

    Range
    4898..110314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013742.4NP_001013764.1  diacylglycerol kinase kappa

    See identical proteins and their annotated locations for NP_001013764.1

    Status: REVIEWED

    Source sequence(s)
    AB183864, AC233286, AC239396, AI591038
    Consensus CDS
    CCDS75980.1
    UniProtKB/Swiss-Prot
    Q5KSL6
    Related
    ENSP00000477515.1, ENST00000611977.2
    Conserved Domains (7) summary
    pfam05887
    Location:123179
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    smart00045
    Location:8571014
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:493615
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:399449
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd13274
    Location:218314
    PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    pfam00169
    Location:217305
    PH; PH domain
    pfam14820
    Location:123185
    SPRR2; Small proline-rich 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    50365409..50470851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029268.2XP_016884757.1  diacylglycerol kinase kappa isoform X1

Support Center