U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CR2 complement C3d receptor 2 [ Homo sapiens (human) ]

Gene ID: 1380, updated on 16-Apr-2024

Summary

Official Symbol
CR2provided by HGNC
Official Full Name
complement C3d receptor 2provided by HGNC
Primary source
HGNC:HGNC:2336
See related
Ensembl:ENSG00000117322 MIM:120650; AllianceGenome:HGNC:2336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR; C3DR; CD21; CVID7; SLEB9
Summary
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in lymph node (RPKM 99.4), spleen (RPKM 44.6) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CR2 in Genome Data Viewer
Location:
1q32.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207454328..207489892)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206719629..206755209)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207627673..207663237)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904498 Neighboring gene uncharacterized LOC105372880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1771 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1772 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207642622-207643821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2447 Neighboring gene complement C3b/C4b receptor 1 (Knops blood group) Neighboring gene NANOG hESC enhancer GRCh37_chr1:207773753-207774311 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:207806821-207807492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207808163-207808834 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207808835-207809506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2448 Neighboring gene CD46 molecule pseudogene 1 Neighboring gene complement C3b/C4b receptor 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency, common variable, 2
MedGen: C3150354 OMIM: 240500 GeneReviews: Not available
Compare labs
Immunodeficiency, common variable, 7
MedGen: C3542922 OMIM: 614699 GeneReviews: Not available
not available
Systemic lupus erythematosus, susceptibility to, 9
MedGen: C1970455 OMIM: 610927 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 transmission to CD4+ T cells from follicular dendritic cells from lymph nodes of infected patients is inhibited by soluble CD21 PubMed
Knockdown of complement component receptor 2 (CR2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 particles (gp120/gp41) bind to MT-2 (CD4+ CR2+) and Raji-3 (CD4- CR2+) cells but not to CEM (CD4+ CR2-) cells, suggesting that the virus binds to CR2 independently of CD4 PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
Vif vif HIV-1 Vif downregulates the expression of complement component receptor 2 (CR2) in Vif-expression T cells PubMed
capsid gag HIV-1 CA p24 is localized to recycling endosomes by CR2 (CD21) and soluble CD21 frees virus from follicular dendritic cells from lymph nodes of HIV infected patients PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables complement binding IDA
Inferred from Direct Assay
more info
PubMed 
enables complement receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in complement activation, alternative pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in complement receptor mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
complement receptor type 2
Names
EBV receptor
complement component (3d/Epstein Barr virus) receptor 2
complement component 3d receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013006.1 RefSeqGene

    Range
    5001..40596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_348

mRNA and Protein(s)

  1. NM_001006658.3NP_001006659.1  complement receptor type 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001006659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK301496, AU133057, AW303499, BQ004295, Y00649
    Consensus CDS
    CCDS31007.1
    UniProtKB/TrEMBL
    Q5SR47
    Related
    ENSP00000356024.3, ENST00000367057.8
    Conserved Domains (1) summary
    cd00033
    Location:410467
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. NM_001877.5NP_001868.2  complement receptor type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001868.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK301496, AU133057, AW303499, BQ004295, Y00649
    Consensus CDS
    CCDS1478.1
    UniProtKB/Swiss-Prot
    C9JHD2, P20023, Q13866, Q14212, Q53EL2, Q5BKT9, Q5SR46, Q5SR48
    UniProtKB/TrEMBL
    Q5SR47
    Related
    ENSP00000356025.3, ENST00000367058.7
    Conserved Domains (1) summary
    cd00033
    Location:410467
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    207454328..207489892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206719629..206755209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)