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Cr2 complement receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12902, updated on 5-Jan-2023

Summary

Official Symbol
Cr2provided by MGI
Official Full Name
complement receptor 2provided by MGI
Primary source
MGI:MGI:88489
See related
Ensembl:ENSMUSG00000026616 AllianceGenome:MGI:88489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cr1; C3DR; CD21; CD35; Cr-1; Cr-2
Summary
Enables complement receptor activity. Acts upstream of or within with a negative effect on complement activation, alternative pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 7.1), mammary gland adult (RPKM 1.4) and 1 other tissue See more
Orthologs
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Genomic context

See Cr2 in Genome Data Viewer
Location:
1 H6; 1 98.44 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194819120..194859096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195136811..195176880, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29c Neighboring gene CD46 antigen, complement regulatory protein Neighboring gene complement component (3b/4b) receptor 1-like Neighboring gene predicted gene, 32313 Neighboring gene predicted gene, 29726 Neighboring gene vomeronasal 2, receptor, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC130295

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables complement binding ISO
Inferred from Sequence Orthology
more info
 
enables complement receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within_negative_effect complement activation, alternative pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
complement receptor type 2
Names
complement C3d receptor
complement receptor type 1
expressed in B lymphocytes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368765.1NP_001355694.1  complement receptor type 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC109145, AC139206
    Consensus CDS
    CCDS87949.1
    UniProtKB/TrEMBL
    A0A1B0GS59
    Conserved Domains (1) summary
    PHA02927
    Location:10272
    PHA02927; secreted complement-binding protein; Provisional
  2. NM_007758.3NP_031784.1  complement receptor type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_031784.1

    Status: VALIDATED

    Source sequence(s)
    AC109145, AC139206
    Consensus CDS
    CCDS15642.1
    UniProtKB/TrEMBL
    Q9DC83
    Related
    ENSMUSP00000080938.4, ENSMUST00000082321.9
    Conserved Domains (2) summary
    PHA02639
    Location:17211
    PHA02639; EEV host range protein; Provisional
    PHA02927
    Location:172407
    PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194819120..194859096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497225.4XP_006497288.1  complement receptor type 2 isoform X3

    See identical proteins and their annotated locations for XP_006497288.1

    UniProtKB/TrEMBL
    Q9DC83
    Conserved Domains (2) summary
    PHA02639
    Location:17211
    PHA02639; EEV host range protein; Provisional
    PHA02927
    Location:172407
    PHA02927; secreted complement-binding protein; Provisional
  2. XM_006497224.4XP_006497287.1  complement receptor type 2 isoform X2

    Conserved Domains (1) summary
    PHA02927
    Location:293528
    PHA02927; secreted complement-binding protein; Provisional
  3. XM_006497222.4XP_006497285.1  complement receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006497285.1

    UniProtKB/TrEMBL
    A0A1B0GS59
    Related
    ENSMUSP00000147804.2, ENSMUST00000210219.2
    Conserved Domains (1) summary
    PHA02927
    Location:10272
    PHA02927; secreted complement-binding protein; Provisional
  4. XM_017314050.3XP_017169539.1  complement receptor type 2 isoform X4

    Conserved Domains (2) summary
    cd00033
    Location:348
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:72307
    PHA02927; secreted complement-binding protein; Provisional

RNA

  1. XR_865893.3 RNA Sequence