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Egr3 early growth response 3 [ Mus musculus (house mouse) ]

Gene ID: 13655, updated on 8-Feb-2024

Summary

Official Symbol
Egr3provided by MGI
Official Full Name
early growth response 3provided by MGI
Primary source
MGI:MGI:1306780
See related
Ensembl:ENSMUSG00000033730 AllianceGenome:MGI:1306780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EGR-3; Pilot
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in genitourinary system; limb mesenchyme; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 18.1), testis adult (RPKM 16.4) and 7 other tissues See more
Orthologs
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Genomic context

See Egr3 in Genome Data Viewer
Location:
14 D2; 14 36.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70314766..70320062)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70077317..70082613)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_37071 Neighboring gene predicted gene, 41198 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene bridging integrator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene cell cycle activator and apoptosis regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • MGC124006, MGC124009

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289925.2NP_001276854.1  early growth response protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001276854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC123867
    Consensus CDS
    CCDS88701.1
    UniProtKB/TrEMBL
    Q3ZB14, Q3ZB15
    Related
    ENSMUSP00000037042.3, ENSMUST00000035908.3
    Conserved Domains (3) summary
    COG5048
    Location:265337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:49109
    DUF3446; Domain of unknown function (DUF3446)
  2. NM_001289927.1NP_001276856.1  early growth response protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC123867, BY238697
    UniProtKB/TrEMBL
    Q3ZB15
    Conserved Domains (3) summary
    COG5048
    Location:249321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:3393
    DUF3446; Domain of unknown function (DUF3446)
  3. NM_018781.4NP_061251.1  early growth response protein 3 isoform 1

    See identical proteins and their annotated locations for NP_061251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123867
    Consensus CDS
    CCDS27246.1
    UniProtKB/Swiss-Prot
    P43300, Q9R276
    UniProtKB/TrEMBL
    Q496R7
    Related
    ENSMUSP00000153491.2, ENSMUST00000225200.2
    Conserved Domains (3) summary
    COG5048
    Location:303375
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:277299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:87147
    DUF3446; Domain of unknown function (DUF3446)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70314766..70320062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)