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Egr3 early growth response 3 [ Mus musculus (house mouse) ]

Gene ID: 13655, updated on 7-Apr-2025

Summary

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Official Symbol
Egr3provided by MGI
Official Full Name
early growth response 3provided by MGI
Primary source
MGI:MGI:1306780
See related
Ensembl:ENSMUSG00000033730 AllianceGenome:MGI:1306780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EGR-3; Pilot
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including ganglionic eminence; genitourinary system; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in cortex adult (RPKM 18.1), testis adult (RPKM 16.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Egr3 in Genome Data Viewer
Location:
14 D2; 14 36.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70314766..70320062)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70077317..70082613)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_37071 Neighboring gene predicted gene, 41198 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene bridging integrator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene cell cycle activator and apoptosis regulator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia. Marballi KK, et al. Transl Psychiatry, 2022 Aug 8. PMID 35941129, Free PMC Article
  2. Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury. Takeoka A, et al. Cell, 2014 Dec 18. PMID 25525880
  3. Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice. Maple AM, et al. J Biol Rhythms, 2018 Dec. PMID 30318979, Free PMC Article
  4. Egr3 induces a Th17 response by promoting the development of γδ T cells. Parkinson RM, et al. PLoS One, 2014. PMID 24475259, Free PMC Article
  5. The Immediate Early Gene Egr3 Is Required for Hippocampal Induction of Bdnf by Electroconvulsive Stimulation. Meyers KT, et al. Front Behav Neurosci, 2018. PMID 29867393, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway.
    Title: EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway.
  2. Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
    Title: Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
  3. Serial electroconvulsive Seizure alters dendritic complexity and promotes cellular proliferation in the mouse dentate gyrus; a role for Egr3.
    Title: Serial electroconvulsive Seizure alters dendritic complexity and promotes cellular proliferation in the mouse dentate gyrus; a role for Egr3.
  4. Egr3 as an important regulator of uterine decidualization through targeting Hand2.
    Title: Egr3 as an important regulator of uterine decidualization through targeting Hand2.
  5. Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.
    Title: Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.
  6. Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation.
    Title: Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation.
  7. Early growth response genes 2 and 3 induced by AP-1 and NF-kappaB modulate TGF-beta1 transcription in NK1.1(-) CD4(+) NKG2D(+) T cells.
    Title: Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1(-) CD4(+) NKG2D(+) T cells.
  8. EGR3-HDAC6-IL-27 Axis Mediates Allergic Inflammation and Is Necessary for Tumorigenic Potential of Cancer Cells Enhanced by Allergic Inflammation-Promoted Cellular Interactions.
    Title: EGR3-HDAC6-IL-27 Axis Mediates Allergic Inflammation and Is Necessary for Tumorigenic Potential of Cancer Cells Enhanced by Allergic Inflammation-Promoted Cellular Interactions.
  9. Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3).
    Title: Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3).
  10. Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1(high) memory phenotype CD4 T cells.
    Title: Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1(high) memory phenotype CD4 T cells.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC124006, MGC124009

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IC
Inferred by Curator
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of gamma-delta T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289925.2 → NP_001276854.1  early growth response protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001276854.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC123867
    Consensus CDS
    CCDS88701.1
    UniProtKB/TrEMBL
    Q3ZB14, Q3ZB15
    Related
    ENSMUSP00000037042.3, ENSMUST00000035908.3
    Conserved Domains (3) summary
    COG5048
    Location:265 → 337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:49 → 109
    DUF3446; Domain of unknown function (DUF3446)

  2. NM_001289927.1 → NP_001276856.1  early growth response protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC123867, BY238697
    UniProtKB/TrEMBL
    Q3ZB15
    Conserved Domains (3) summary
    COG5048
    Location:249 → 321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:33 → 93
    DUF3446; Domain of unknown function (DUF3446)

  3. NM_018781.4 → NP_061251.1  early growth response protein 3 isoform 1

    See identical proteins and their annotated locations for NP_061251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC123867
    Consensus CDS
    CCDS27246.1
    UniProtKB/Swiss-Prot
    P43300, Q9R276
    UniProtKB/TrEMBL
    Q496R7
    Related
    ENSMUSP00000153491.2, ENSMUST00000225200.2
    Conserved Domains (3) summary
    COG5048
    Location:303 → 375
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:277 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:87 → 147
    DUF3446; Domain of unknown function (DUF3446)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70314766..70320062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43300.2 GenPept UniProtKB/Swiss-Prot:P43300

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