Egr3 early growth response 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Egr3provided by MGI
Official Full Name: early growth response 3provided by MGI
Primary source: MGI:MGI:1306780
See related: Ensembl:ENSMUSG00000033730 AllianceGenome:MGI:1306780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EGR-3; Pilot
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; and regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in genitourinary system; limb mesenchyme; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 18.1), testis adult (RPKM 16.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14; 14 D2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70314766..70320062)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70077317..70082613)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Egr3 as an important regulator of uterine decidualization through targeting Hand2.
Title: Egr3 as an important regulator of uterine decidualization through targeting Hand2.
Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.
Title: Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.
Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation.
Title: Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation.
Early growth response genes 2 and 3 induced by AP-1 and NF-kappaB modulate TGF-beta1 transcription in NK1.1(-) CD4(+) NKG2D(+) T cells.
Title: Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1(-) CD4(+) NKG2D(+) T cells.
EGR3-HDAC6-IL-27 Axis Mediates Allergic Inflammation and Is Necessary for Tumorigenic Potential of Cancer Cells Enhanced by Allergic Inflammation-Promoted Cellular Interactions.
Title: EGR3-HDAC6-IL-27 Axis Mediates Allergic Inflammation and Is Necessary for Tumorigenic Potential of Cancer Cells Enhanced by Allergic Inflammation-Promoted Cellular Interactions.
Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3).
Title: Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating Early Growth Response Protein 3 (EGR3).
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1(high) memory phenotype CD4 T cells.
Title: Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1(high) memory phenotype CD4 T cells.
Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration.
Title: Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration.
Our results suggest that Egr3-/- mice retain control over the circadian timekeeping of sleep and wake, while showing impaired sleep.
Title: Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice.
Study findings demonstrated that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and Egr3.
Title: Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Egr3 gene: The Egr3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 468 organisms have orthologs with human gene Egr3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gamma-delta T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289925.2 → NP_001276854.1 early growth response protein 3 isoform 2

See identical proteins and their annotated locations for NP_001276854.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC123867

Consensus CDS

CCDS88701.1

UniProtKB/TrEMBL

A0A6P5R166, A0A8C6N502, Q3ZB14

Related

ENSMUSP00000037042.3, ENSMUST00000035908.3

Conserved Domains (3) summary

COG5048
Location:265 → 337

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:239 → 261

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam11928
Location:49 → 109

DUF3446; Domain of unknown function (DUF3446)
NM_001289927.1 → NP_001276856.1 early growth response protein 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC123867, BY238697

UniProtKB/TrEMBL

A0A6P5R3B2

Conserved Domains (3) summary

COG5048
Location:249 → 321

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 245

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam11928
Location:33 → 93

DUF3446; Domain of unknown function (DUF3446)
NM_018781.4 → NP_061251.1 early growth response protein 3 isoform 1

See identical proteins and their annotated locations for NP_061251.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC123867

Consensus CDS

CCDS27246.1

UniProtKB/Swiss-Prot

P43300, Q9R276

UniProtKB/TrEMBL

A0A6P5R6M7, A0A8C6IGN9

Related

ENSMUSP00000153491.2, ENSMUST00000225200.2

Conserved Domains (3) summary

COG5048
Location:303 → 375

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:277 → 299

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam11928
Location:87 → 147

DUF3446; Domain of unknown function (DUF3446)