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Dst dystonin [ Mus musculus (house mouse) ]

Gene ID: 13518, updated on 17-Jan-2023

Summary

Official Symbol
Dstprovided by MGI
Official Full Name
dystoninprovided by MGI
Primary source
MGI:MGI:104627
See related
Ensembl:ENSMUSG00000026131 AllianceGenome:MGI:104627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ah; dt; Bpag; BP230; Bpag1; Macf2; nmf203; nmf339; BPAG1-n; athetoid; mKIAA0728; 2310001O04Rik; A830042E19Rik
Summary
Enables microtubule binding activity and protein homodimerization activity. Involved in cytoskeleton organization and intracellular transport. Acts upstream of or within several processes, including cytoplasmic microtubule organization; regulation of microtubule polymerization or depolymerization; and retrograde axonal transport. Located in several cellular components, including cytoskeleton; endoplasmic reticulum; and sarcomere. Is active in type III intermediate filament. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina nuclear layer. Used to study hereditary sensory and autonomic neuropathy type 6 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 8.8), bladder adult (RPKM 7.5) and 28 other tissues See more
Orthologs
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Genomic context

See Dst in Genome Data Viewer
Location:
1 B; 1 12.91 cM
Exon count:
113
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33946969..34347743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33907888..34308662)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15455 Neighboring gene BEN domain containing 6 Neighboring gene predicted gene, 38471 Neighboring gene predicted gene, 53546 Neighboring gene predicted gene, 23792 Neighboring gene microRNA 6896 Neighboring gene predicted gene, 51742 Neighboring gene predicted gene, 26788 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene 3052

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in hemidesmosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retrograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde axonal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in H zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hemidesmosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in type III intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dystonin
Names
BPA
dystonia musculorum protein
hemidesmosomal plaque protein
microtubule actin cross-linking factor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276764.1NP_001263693.1  dystonin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC123072, AC124386, AC127433
    Consensus CDS
    CCDS69874.1
    UniProtKB/TrEMBL
    S4R1P5
    Related
    ENSMUSP00000138308.2, ENSMUST00000183034.5
    Conserved Domains (9) summary
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    cd00014
    Location:214316
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73107372
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64886703
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:37154529
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:19501990
    Plectin; Plectin repeat
    pfam02187
    Location:73887461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:73117371
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:13711535
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_010081.3NP_034211.2  dystonin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as e) has multiple differences in the coding region and UTRs compared to variant 1. This variant encodes isoform 4 (also known as e), which has distinct N- and C-termini and is significantly shorter than isoform 1.
    Source sequence(s)
    AC127433
    Consensus CDS
    CCDS69875.1
    UniProtKB/Swiss-Prot
    Q91ZU6
    Related
    ENSMUSP00000138376.4, ENSMUST00000183302.6
    Conserved Domains (7) summary
    smart00150
    Location:282373
    SPEC; Spectrin repeats
    smart00250
    Location:25042541
    PLEC; Plectin repeat
    COG1196
    Location:7211477
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:375563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:24672506
    Plectin; Plectin repeat
    pfam09728
    Location:13991712
    Taxilin; Myosin-like coiled-coil protein
    cl02488
    Location:8671031
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. NM_133833.4NP_598594.2  dystonin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks seven alternate in-frame exons in the coding region. The encoded isoform (3, also known as a) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123072, AC124386, AC127433
    Consensus CDS
    CCDS35535.1
    UniProtKB/Swiss-Prot
    Q91ZU6
    Related
    ENSMUSP00000095393.3, ENSMUST00000097786.10
    Conserved Domains (8) summary
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    cd00014
    Location:36138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:50095071
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:41874402
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:14802337
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02187
    Location:50875160
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:50105070
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:11931357
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. NM_134448.4NP_604443.2  dystonin isoform 2

    See identical proteins and their annotated locations for NP_604443.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as b) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks two alternate in-frame exons in the coding region. The encoded isoform (2, also known as b) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC123072, AC124386, AC127433
    Consensus CDS
    CCDS35534.1
    UniProtKB/Swiss-Prot
    Q91ZU6, S4R1U5
    Related
    ENSMUSP00000095392.3, ENSMUST00000097785.10
    Conserved Domains (9) summary
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    cd00014
    Location:36138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:70237085
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62016416
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:35374351
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:17721812
    Plectin; Plectin repeat
    pfam02187
    Location:71017174
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:70247084
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:11931357
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33946969..34347743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495666.4XP_006495729.1  dystonin isoform X3

    Conserved Domains (12) summary
    pfam05483
    Location:12611451
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    COG1196
    Location:43465241
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208432
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73117373
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64896704
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36624440
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12851723
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19511991
    Plectin; Plectin repeat
    pfam02187
    Location:73887462
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10541120
    SH3_10; SH3 domain
    pfam18373
    Location:11551232
    Spectrin_like; Spectrin like domain
  2. XM_006495690.4XP_006495753.1  dystonin isoform X34

    Conserved Domains (12) summary
    pfam05483
    Location:12611451
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:73867458
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    COG1196
    Location:43465241
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208432
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73117373
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64896704
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36624440
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12851723
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19511991
    Plectin; Plectin repeat
    pfam17902
    Location:10541120
    SH3_10; SH3 domain
    pfam18373
    Location:11551232
    Spectrin_like; Spectrin like domain
  3. XM_006495691.4XP_006495754.1  dystonin isoform X33

    Conserved Domains (12) summary
    pfam05483
    Location:12611451
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:72777355
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    COG1196
    Location:43465241
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208432
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:72027264
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63806595
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36624440
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12851723
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19511991
    Plectin; Plectin repeat
    pfam17902
    Location:10541120
    SH3_10; SH3 domain
    pfam18373
    Location:11551232
    Spectrin_like; Spectrin like domain
  4. XM_036158508.1XP_036014401.1  dystonin isoform X23

    Conserved Domains (11) summary
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    COG1196
    Location:23323227
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:52975359
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:44754690
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16592516
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:13851811
    CCDC158; Coiled-coil domain-containing protein 158
    pfam02187
    Location:53745448
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10541120
    SH3_10; SH3 domain
    pfam18373
    Location:11551232
    Spectrin_like; Spectrin like domain
    cd21236
    Location:201325
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:330433
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
  5. XM_006495682.3XP_006495745.1  dystonin isoform X24

    Conserved Domains (11) summary
    pfam05483
    Location:12611451
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:786877
    SPEC; Spectrin repeats
    COG1196
    Location:23323227
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208432
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:52975359
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:44754690
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16592516
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:13721536
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:53745448
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10541120
    SH3_10; SH3 domain
    pfam18373
    Location:11551232
    Spectrin_like; Spectrin like domain
  6. XM_017314621.2XP_017170110.1  dystonin isoform X1

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:74007474
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  7. XM_017314676.2XP_017170165.1  dystonin isoform X6

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:74007474
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  8. XM_017314651.2XP_017170140.1  dystonin isoform X4

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:73987476
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  9. XM_017314687.2XP_017170176.1  dystonin isoform X8

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:73987476
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  10. XM_017314635.2XP_017170124.1  dystonin isoform X2

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:74007468
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  11. XM_030246500.1XP_030102360.1  dystonin isoform X7

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:74007468
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  12. XM_017314665.2XP_017170154.1  dystonin isoform X5

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:73987470
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  13. XM_017314706.2XP_017170195.1  dystonin isoform X11

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:72147276
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63926607
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:72917365
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  14. XM_017314722.2XP_017170211.1  dystonin isoform X14

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:72147276
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63926607
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam02187
    Location:72917365
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  15. XM_017314794.2XP_017170283.1  dystonin isoform X22

    Conserved Domains (11) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:23443239
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:53095371
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:44874702
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16712528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:13841548
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:53865460
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  16. XM_017314811.2XP_017170300.1  dystonin isoform X25

    Conserved Domains (11) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:23443239
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:52005262
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:43784593
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:16712528
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:13841548
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:52775351
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  17. XM_017314689.2XP_017170178.1  dystonin isoform X9

    Conserved Domains (12) summary
    pfam05483
    Location:12731463
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00243
    Location:73987470
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:798889
    SPEC; Spectrin repeats
    COG1196
    Location:43585253
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:208444
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:73237385
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:65016716
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36744452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12971735
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:19632003
    Plectin; Plectin repeat
    pfam17902
    Location:10661132
    SH3_10; SH3 domain
    pfam18373
    Location:11671244
    Spectrin_like; Spectrin like domain
  18. XM_017314716.3XP_017170205.1  dystonin isoform X13

    Conserved Domains (12) summary
    pfam05483
    Location:11351325
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:660751
    SPEC; Spectrin repeats
    COG1196
    Location:42205115
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:70306
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71857247
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63636578
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:35364314
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11591597
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:18251865
    Plectin; Plectin repeat
    pfam02187
    Location:72627336
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:928994
    SH3_10; SH3 domain
    pfam18373
    Location:10291106
    Spectrin_like; Spectrin like domain
  19. XM_006495674.5XP_006495737.1  dystonin isoform X15

    Conserved Domains (12) summary
    pfam05483
    Location:11231313
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:648739
    SPEC; Spectrin repeats
    COG1196
    Location:42085103
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:70294
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71737235
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63516566
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:35244302
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11471585
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:18131853
    Plectin; Plectin repeat
    pfam02187
    Location:72507324
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:916982
    SH3_10; SH3 domain
    pfam18373
    Location:10171094
    Spectrin_like; Spectrin like domain
  20. XM_017314712.3XP_017170201.1  dystonin isoform X12

    Conserved Domains (12) summary
    pfam05483
    Location:11391329
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:664755
    SPEC; Spectrin repeats
    COG1196
    Location:42245119
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:74310
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71897251
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63676582
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:35404318
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11631601
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:18291869
    Plectin; Plectin repeat
    pfam02187
    Location:72667340
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:932998
    SH3_10; SH3 domain
    pfam18373
    Location:10331110
    Spectrin_like; Spectrin like domain
  21. XM_017314741.2XP_017170230.1  dystonin isoform X16

    Conserved Domains (12) summary
    pfam05483
    Location:10951285
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:620711
    SPEC; Spectrin repeats
    COG1196
    Location:41805075
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35266
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71457207
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63236538
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:34964274
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11191557
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:17851825
    Plectin; Plectin repeat
    pfam02187
    Location:72227296
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:888954
    SH3_10; SH3 domain
    pfam18373
    Location:9891066
    Spectrin_like; Spectrin like domain
  22. XM_006495678.4XP_006495741.1  dystonin isoform X18

    Conserved Domains (12) summary
    pfam05483
    Location:10831273
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:41685063
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71337195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63116526
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:34844262
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11071545
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:17731813
    Plectin; Plectin repeat
    pfam02187
    Location:72107284
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
  23. XM_006495688.4XP_006495751.1  dystonin isoform X32

    Conserved Domains (12) summary
    pfam05483
    Location:10831273
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:41685063
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71337195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63116526
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:34844262
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11071545
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:17731813
    Plectin; Plectin repeat
    pfam02187
    Location:72107284
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
  24. XM_017314848.2XP_017170337.1  dystonin isoform X31

    Conserved Domains (12) summary
    pfam05483
    Location:10831273
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:41685063
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:70247086
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62026417
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:34844262
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11071545
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:17731813
    Plectin; Plectin repeat
    pfam02187
    Location:71017175
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
  25. XM_006495684.4XP_006495747.1  dystonin isoform X26

    Conserved Domains (11) summary
    pfam05483
    Location:10831273
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:21543049
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:51195181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:42974512
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:14812338
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:11941358
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:51965270
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
  26. XM_036158554.1XP_036014447.1  dystonin isoform X27

    Conserved Domains (11) summary
    smart00243
    Location:51945266
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:21543049
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:51195181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:42974512
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:14812338
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12071633
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
    cd21236
    Location:20147
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cd21239
    Location:152255
    CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
  27. XM_017314868.2XP_017170357.1  dystonin isoform X28

    Conserved Domains (11) summary
    pfam05483
    Location:10831273
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:608699
    SPEC; Spectrin repeats
    COG1196
    Location:21543049
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:35254
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:50105072
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:41884403
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:14812338
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:11941358
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:50875161
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:876942
    SH3_10; SH3 domain
    pfam18373
    Location:9771054
    Spectrin_like; Spectrin like domain
  28. XM_017314750.3XP_017170239.1  dystonin isoform X17

    Conserved Domains (12) summary
    pfam05483
    Location:10881278
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:613704
    SPEC; Spectrin repeats
    COG1196
    Location:41735068
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:28259
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:71387200
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63166531
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:34894267
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11121550
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:17781818
    Plectin; Plectin repeat
    pfam02187
    Location:72157289
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:881947
    SH3_10; SH3 domain
    pfam18373
    Location:9821059
    Spectrin_like; Spectrin like domain
  29. XM_006495679.4XP_006495742.1  dystonin isoform X19

    Conserved Domains (12) summary
    pfam05483
    Location:9961186
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:521612
    SPEC; Spectrin repeats
    COG1196
    Location:40814976
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:1167
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:70467108
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62246439
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:33974175
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:10201458
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:16861726
    Plectin; Plectin repeat
    pfam02187
    Location:71237197
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:789855
    SH3_10; SH3 domain
    pfam18373
    Location:890967
    Spectrin_like; Spectrin like domain
  30. XM_006495669.5XP_006495732.1  dystonin isoform X10

    Conserved Domains (12) summary
    pfam05483
    Location:11991389
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:724815
    SPEC; Spectrin repeats
    COG1196
    Location:42845179
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:268371
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:72497311
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64276642
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:36004378
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:12231661
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:18891929
    Plectin; Plectin repeat
    pfam02187
    Location:73267400
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:9921058
    SH3_10; SH3 domain
    pfam18373
    Location:10931170
    Spectrin_like; Spectrin like domain
  31. XM_006495686.5XP_006495749.1  dystonin isoform X30

    Conserved Domains (8) summary
    smart00150
    Location:282373
    SPEC; Spectrin repeats
    smart00250
    Location:25052542
    PLEC; Plectin repeat
    COG1196
    Location:6781404
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:375564
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:10981859
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:24682507
    Plectin; Plectin repeat
    pfam17902
    Location:550616
    SH3_10; SH3 domain
    pfam18373
    Location:651728
    Spectrin_like; Spectrin like domain
  32. XM_006495680.5XP_006495743.1  dystonin isoform X20

    Conserved Domains (11) summary
    pfam05483
    Location:757947
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:282373
    SPEC; Spectrin repeats
    COG1196
    Location:38424737
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:68076869
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:59856200
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:31583936
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:7811219
    CCDC158; Coiled-coil domain-containing protein 158
    pfam00681
    Location:14471487
    Plectin; Plectin repeat
    pfam02187
    Location:68846958
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:550616
    SH3_10; SH3 domain
    pfam18373
    Location:651728
    Spectrin_like; Spectrin like domain
  33. XM_006495685.2XP_006495748.1  dystonin isoform X29

    Related
    ENSMUSP00000141127.2, ENSMUST00000185269.7
    Conserved Domains (10) summary
    pfam05483
    Location:757947
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00150
    Location:282373
    SPEC; Spectrin repeats
    COG1196
    Location:18282723
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:47934855
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:39714186
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:11552012
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:8681032
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:48704944
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam17902
    Location:550616
    SH3_10; SH3 domain
    pfam18373
    Location:651728
    Spectrin_like; Spectrin like domain
  34. XM_030246701.2XP_030102561.1  dystonin isoform X21

    Conserved Domains (7) summary
    smart00150
    Location:53225449
    SPEC; Spectrin repeats
    COG1196
    Location:25183413
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:54835545
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:46614876
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:18342612
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:123163
    Plectin; Plectin repeat
    pfam02187
    Location:55605634
    GAS2; Growth-Arrest-Specific Protein 2 Domain