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ADORA2A adenosine A2a receptor [ Homo sapiens (human) ]

Gene ID: 135, updated on 23-Nov-2023

Summary

Official Symbol
ADORA2Aprovided by HGNC
Official Full Name
adenosine A2a receptorprovided by HGNC
Primary source
HGNC:HGNC:263
See related
Ensembl:ENSG00000128271 MIM:102776; AllianceGenome:HGNC:263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2aR; RDC8; ADORA2
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Expression
Broad expression in bone marrow (RPKM 12.9), lymph node (RPKM 8.9) and 22 other tissues See more
Orthologs
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Genomic context

See ADORA2A in Genome Data Viewer
Location:
22q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (24423597..24442357)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24885210..24903991)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24819565..24838325)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SPECC1L-ADORA2A readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24680125-24680630 Neighboring gene ribosomal protein S10 pseudogene 29 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 like Neighboring gene Sharpr-MPRA regulatory region 3008 Neighboring gene Sharpr-MPRA regulatory region 3699 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:24712259-24712996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24734941-24735636 Neighboring gene uncharacterized LOC105372960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24804357-24804858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24804859-24805358 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24813636-24813812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24814323-24814932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24816151-24816760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24817371-24817980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24820284-24820935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24820936-24821586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24825428-24826389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24829365-24829914 Neighboring gene ADORA2A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24831043-24831543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13551 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24840685-24840876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18773 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24875502-24875689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24901494-24902032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24902033-24902569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18776 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:24905414-24905687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18778 Neighboring gene beta-ureidopropionase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18779 Neighboring gene guanylyl cyclase domain containing 1 Neighboring gene small nuclear ribonucleoprotein D3 polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Activation of adenosine A2a receptor with CGS 21680 inhibits Tat-induced increases of intracellular calcium and this inhibition is dependent on protein phosphatase activity in monocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough SPECC1L-ADORA2A

Readthrough gene: SPECC1L-ADORA2A, Included gene: SPECC1L

Clone Names

  • FLJ61179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled adenosine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-actinin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding EXP
Inferred from Experiment
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables type 5 metabotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte activation IEA
Inferred from Electronic Annotation
more info
 
involved_in blood circulation TAS
Traceable Author Statement
more info
PubMed 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in inhibitory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of alpha-beta T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of circadian sleep/wake cycle, sleep IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
involved_in prepulse inhibition IEA
Inferred from Electronic Annotation
more info
 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to caffeine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to purine-containing compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in asymmetric synapse IEA
Inferred from Electronic Annotation
more info
 
located_in axolemma IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenosine receptor A2a
Names
adenosine receptor subtype A2a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052804.1 RefSeqGene

    Range
    9003..23761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000675.6NP_000666.2  adenosine receptor A2a

    See identical proteins and their annotated locations for NP_000666.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK123058, BC013780, CA307692, DA942067
    Consensus CDS
    CCDS13826.1
    UniProtKB/Swiss-Prot
    B2R7E0, P29274
    UniProtKB/TrEMBL
    A8K1F6, B3KVQ4, X5DNB4
    Related
    ENSP00000336630.6, ENST00000337539.12
    Conserved Domains (1) summary
    cd15068
    Location:7299
    7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001278497.2NP_001265426.1  adenosine receptor A2a

    See identical proteins and their annotated locations for NP_001265426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants, 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK289871, BG686029, CA307692, CN408252, HY249059
    Consensus CDS
    CCDS13826.1
    UniProtKB/Swiss-Prot
    B2R7E0, P29274
    UniProtKB/TrEMBL
    A8K1F6, B3KVQ4, X5DNB4
    Related
    ENSP00000480012.1, ENST00000610595.4
    Conserved Domains (1) summary
    cd15068
    Location:7299
    7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001278498.2NP_001265427.1  adenosine receptor A2a

    See identical proteins and their annotated locations for NP_001265427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    BG686029, CA307692, CR456367, DA270141, HY249059
    Consensus CDS
    CCDS13826.1
    UniProtKB/Swiss-Prot
    B2R7E0, P29274
    UniProtKB/TrEMBL
    A8K1F6, B3KVQ4, X5DNB4
    Related
    ENSP00000481552.1, ENST00000618076.3
    Conserved Domains (1) summary
    cd15068
    Location:7299
    7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001278499.2NP_001265428.1  adenosine receptor A2a

    See identical proteins and their annotated locations for NP_001265428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    BG686029, CA307692, CR456367, DA942067, HY249059
    Consensus CDS
    CCDS13826.1
    UniProtKB/Swiss-Prot
    B2R7E0, P29274
    UniProtKB/TrEMBL
    A8K1F6, B3KVQ4, X5DNB4
    Conserved Domains (1) summary
    cd15068
    Location:7299
    7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001278500.2NP_001265429.1  adenosine receptor A2a

    See identical proteins and their annotated locations for NP_001265429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants, 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    BG686029, CA307692, CR456367, DA781734, HY249059
    Consensus CDS
    CCDS13826.1
    UniProtKB/Swiss-Prot
    B2R7E0, P29274
    UniProtKB/TrEMBL
    A8K1F6, B3KVQ4, X5DNB4
    Related
    ENSP00000483102.1, ENST00000611543.4
    Conserved Domains (1) summary
    cd15068
    Location:7299
    7tmA_Adenosine_R_A2A; adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_103543.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BG686029, CA307692, DA687739, DA942067, HY102778, HY249059
  2. NR_103544.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BG686029, CA307692, DA687739, DA942067, DA983859, HY249059

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    24423597..24442357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24885210..24903991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)