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COX7B cytochrome c oxidase subunit 7B [ Homo sapiens (human) ]

Gene ID: 1349, updated on 7-Jun-2020

Summary

Official Symbol
COX7Bprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 7Bprovided by HGNC
Primary source
HGNC:HGNC:2291
See related
Ensembl:ENSG00000131174 MIM:300885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APLCC; LSDMCA2
Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in heart (RPKM 234.2), kidney (RPKM 174.2) and 24 other tissues See more
Orthologs

Genomic context

See COX7B in Genome Data Viewer
Location:
Xq21.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (77899468..77907376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77154961..77160881)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene magnesium transporter 1 Neighboring gene RNA, 7SL, cytoplasmic 460, pseudogene Neighboring gene ATPase copper transporting alpha Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene phosphoglycerate mutase family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain IEA
Inferred from Electronic Annotation
more info
 
respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 7B, mitochondrial
Names
cytochrome c oxidase polypeptide VIIb
cytochrome c oxidase subunit VIIb
cytochrome-c oxidase chain VIIb
NP_001857.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033027.2 RefSeqGene

    Range
    5005..12913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1250

mRNA and Protein(s)

  1. NM_001866.3NP_001857.1  cytochrome c oxidase subunit 7B, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001857.1

    Status: REVIEWED

    Source sequence(s)
    AL356235, Z14244
    Consensus CDS
    CCDS14437.1
    UniProtKB/Swiss-Prot
    P24311
    Related
    ENSP00000497474.1, ENST00000650309.2
    Conserved Domains (1) summary
    pfam05392
    Location:179
    COX7B; Cytochrome C oxidase chain VIIB

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    77899468..77907376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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