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Dcn decorin [ Mus musculus (house mouse) ]

Gene ID: 13179, updated on 5-Mar-2024

Summary

Official Symbol
Dcnprovided by MGI
Official Full Name
decorinprovided by MGI
Primary source
MGI:MGI:94872
See related
Ensembl:ENSMUSG00000019929 AllianceGenome:MGI:94872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DC; PG40; PGII; PGS2; DSPG2; SLRR1B
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate a mature protein product, which is secreted into the extracellular space to regulate collagen fibril assembly. Homozygous knockout mice for this gene exhibit enhanced tumorigenesis in a liver cancer model, and defects in collagen fibrils, leading to weakened skin and tendons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in bladder adult (RPKM 1095.0), subcutaneous fat pad adult (RPKM 305.9) and 7 other tissues See more
Orthologs
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Genomic context

See Dcn in Genome Data Viewer
Location:
10 C3; 10 50.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97315362..97354025)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97479500..97518163)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CWC15 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8867 Neighboring gene STARR-seq mESC enhancer starr_27689 Neighboring gene STARR-positive B cell enhancer ABC_E6912 Neighboring gene predicted gene, 34114 Neighboring gene microRNA 3966 Neighboring gene STARR-seq mESC enhancer starr_27690 Neighboring gene STARR-seq mESC enhancer starr_27691 Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of collagen type VI trimer ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
decorin
Names
bone proteoglycan II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190451.2NP_001177380.1  decorin preproprotein

    See identical proteins and their annotated locations for NP_001177380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC159710, AK145905, BG088078, BM114383
    Consensus CDS
    CCDS24141.1
    UniProtKB/Swiss-Prot
    P28654
    UniProtKB/TrEMBL
    Q3TSV1, Q3UKR1
    Related
    ENSMUSP00000100924.4, ENSMUST00000105287.11
    Conserved Domains (4) summary
    smart00013
    Location:4880
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:79285
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5777
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:79136
    LRR_8; Leucine rich repeat
  2. NM_007833.6NP_031859.1  decorin preproprotein

    See identical proteins and their annotated locations for NP_031859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA881173, AC159710, BB575065, BM114383, CK623125, DV056002, W62675
    Consensus CDS
    CCDS24141.1
    UniProtKB/Swiss-Prot
    P28654
    UniProtKB/TrEMBL
    Q3TSV1, Q3UKR1
    Related
    ENSMUSP00000131431.3, ENSMUST00000163448.4
    Conserved Domains (4) summary
    smart00013
    Location:4880
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:79285
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5777
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:79136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    97315362..97354025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)