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DCN decorin [ Homo sapiens (human) ]

Gene ID: 1634, updated on 7-Dec-2018

Summary

Official Symbol
DCNprovided by HGNC
Official Full Name
decorinprovided by HGNC
Primary source
HGNC:HGNC:2705
See related
Ensembl:ENSG00000011465 MIM:125255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
Summary
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Expression
Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more
Orthologs

Genomic context

See DCN in Genome Data Viewer
Location:
12q21.33
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (91143277..91183124, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (91539035..91576806, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratocan Neighboring gene lumican Neighboring gene uncharacterized LOC105369898 Neighboring gene uncharacterized LOC107984544 Neighboring gene uncharacterized LOC105369897 Neighboring gene uncharacterized LOC105369896

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital Stromal Corneal Dystrophy Compare labs

NHGRI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystem (from REACTOME)
    A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystemThe biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The ...
  • BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystem (from WikiPathways)
    BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystemThis pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO...
  • CS/DS degradation, organism-specific biosystem (from REACTOME)
    CS/DS degradation, organism-specific biosystemLysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of chondroitin sulfate and dermatan su...
  • Chondroitin sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Chondroitin sulfate biosynthesis, organism-specific biosystemChondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying ...
  • Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystem (from REACTOME)
    Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystemChondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-a...
  • Defective B3GALT6 causes EDSP2 and SEMDJL1, organism-specific biosystem (from REACTOME)
    Defective B3GALT6 causes EDSP2 and SEMDJL1, organism-specific biosystemThe biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence attached to the core prot...
  • Defective B3GAT3 causes JDSSDHD, organism-specific biosystem (from REACTOME)
    Defective B3GAT3 causes JDSSDHD, organism-specific biosystemGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferases1, 2 and 3 (B3GAT1-3) are involved in forming the linker tetrasaccharide present in heparan sulfate and chondroitin sulfate. Defects ...
  • Defective B4GALT7 causes EDS, progeroid type, organism-specific biosystem (from REACTOME)
    Defective B4GALT7 causes EDS, progeroid type, organism-specific biosystemEhlers?Danlos syndrome (EDS) is a group of inherited connective tissue disorders, caused by a defect in the synthesis of collagen types I or III. Abnormal collagen renders connective tissues more ela...
  • Defective CHST14 causes EDS, musculocontractural type, organism-specific biosystem (from REACTOME)
    Defective CHST14 causes EDS, musculocontractural type, organism-specific biosystemCarbohydrate sulfotransferase 14 (CHST14 also known as D4ST-1) mediates the transfer of sulfate to position 4 of further N-acetylgalactosamine (GalNAc) residues of dermatan sulfate (DS). Defects in C...
  • Defective CHST3 causes SEDCJD, organism-specific biosystem (from REACTOME)
    Defective CHST3 causes SEDCJD, organism-specific biosystemCarbohydrate sulfotransferase 3 (CHST3) transfers sulfate (SO4(2-)) to position 6 of N-acetylgalactosamine (GalNAc) residues of chondroitin-containg proteins resulting in chondroitin sulfate (CS), th...
  • Defective CHSY1 causes TPBS, organism-specific biosystem (from REACTOME)
    Defective CHSY1 causes TPBS, organism-specific biosystemChondroitin sulfate synthases (CHSY) are involved in the synthesis of chondroitin sulfate, adding alternatingly glucuronate (GlcA) and N-acetylgalactosamine (GalNAc) to the growing chondroitin polyme...
  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Dermatan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Dermatan sulfate biosynthesis, organism-specific biosystemDermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues ...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Diseases associated with glycosaminoglycan metabolism, organism-specific biosystemA number of genetic disorders are caused by mutations in the genes encoding glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of glycosaminoglycans (GAGs) as well as ...
  • Diseases of glycosylation, organism-specific biosystem (from REACTOME)
    Diseases of glycosylation, organism-specific biosystemDiseases of glycosylation, usually referred to as congenital disorders of glycosylation (CDG), are rare inherited disorders ascribing defects of nucleotide-sugar biosynthesis and transport, glycosylt...
  • ECM proteoglycans, organism-specific biosystem (from REACTOME)
    ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystem (from REACTOME)
    Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystemThe acronym HS-GAG is used to describe both heparin and heparan sulfate. HS-GAG is a member of the glycosaminoglycan family and consists of a variably sulfated repeating disaccharide unit, the most ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
    Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
    Validated transcriptional targets of AP1 family members Fra1 and Fra2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
collagen binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent conferring compression resistance HDA PubMed 
extracellular matrix structural constituent conferring compression resistance ISS
Inferred from Sequence or Structural Similarity
more info
 
glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
chondroitin sulfate catabolic process TAS
Traceable Author Statement
more info
 
dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA
Inferred from Electronic Annotation
more info
 
placenta development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitochondrial depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitochondrial fission IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
decorin
Names
bone proteoglycan II
dermatan sulphate proteoglycans II
proteoglycan core protein
small leucine-rich protein 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011672.1 RefSeqGene

    Range
    4906..44753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001920.5NP_001911.1  decorin isoform a preproprotein

    See identical proteins and their annotated locations for NP_001911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A1) represents the longest transcript and encodes the longest isoform. Both variants A1 and A2 encode the same isoform (a).
    Source sequence(s)
    AC007115, AW444736, BM672011, BX094949, BX571756, CD689331
    Consensus CDS
    CCDS9039.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000052754.5, ENST00000052754.9
    Conserved Domains (3) summary
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:5480
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70298
    NEL; C-terminal novel E3 ligase, LRR-interacting
  2. NM_133503.3NP_598010.1  decorin isoform a preproprotein

    See identical proteins and their annotated locations for NP_598010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A2) differs in the 5' UTR compared to variant A1. Both variants A1 and A2 encode the same isoform (a).
    Source sequence(s)
    AC007115, AW444736, BM672011, BX094949, BX571756, DA424310
    Consensus CDS
    CCDS9039.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000376862.1, ENST00000393155.5
    Conserved Domains (3) summary
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:5480
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70298
    NEL; C-terminal novel E3 ligase, LRR-interacting
  3. NM_133504.3NP_598011.1  decorin isoform b precursor

    See identical proteins and their annotated locations for NP_598011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138301, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9040.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000413723.2, ENST00000420120.6
    Conserved Domains (4) summary
    smart00013
    Location:5477
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:7092
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:112172
    LRR_8; Leucine rich repeat
    cl26793
    Location:70196
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. NM_133505.3NP_598012.1  decorin isoform c precursor

    See identical proteins and their annotated locations for NP_598012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR and lacks three alternate exons in the coding region compared to variant A1. The encoded isoform (c) is shorter than isoform a. This isoform (c) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138302, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9041.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    A0A024RBG6, Q6FH10
    Related
    ENSP00000401021.1, ENST00000425043.5
    Conserved Domains (3) summary
    smart00013
    Location:5476
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:7699
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:74134
    LRR_8; Leucine rich repeat
  5. NM_133506.3NP_598013.1  decorin isoform d precursor

    See identical proteins and their annotated locations for NP_598013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' UTR and lacks four alternate exons in the coding region compared to variant A1. The encoded isoform (d) is shorter than isoform a. This isoform (d) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138303, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS9042.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000399815.2, ENST00000441303.6
    Conserved Domains (3) summary
    smart00013
    Location:5485
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:84125
    LRR_8; Leucine rich repeat
  6. NM_133507.3NP_598014.1  decorin isoform e precursor

    See identical proteins and their annotated locations for NP_598014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) differs in the 5' UTR and lacks five alternate exons in the coding region compared to variant A1. The encoded isoform (e) is shorter than isoform a. This isoform (e) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    AC007115, AF138304, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244
    Consensus CDS
    CCDS44951.1
    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000398514.2, ENST00000456569.2
    Conserved Domains (1) summary
    cl02423
    Location:5471
    LRRNT; Leucine rich repeat N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    91143277..91183124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719270.1XP_006719333.1  decorin isoform X1

    See identical proteins and their annotated locations for XP_006719333.1

    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Related
    ENSP00000447654.1, ENST00000552962.5
    Conserved Domains (3) summary
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:5480
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70298
    NEL; C-terminal novel E3 ligase, LRR-interacting
  2. XM_017018917.1XP_016874406.1  decorin isoform X1

    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Conserved Domains (3) summary
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:5480
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70298
    NEL; C-terminal novel E3 ligase, LRR-interacting
  3. XM_005268693.1XP_005268750.1  decorin isoform X1

    See identical proteins and their annotated locations for XP_005268750.1

    UniProtKB/Swiss-Prot
    P07585
    UniProtKB/TrEMBL
    Q6FH10
    Conserved Domains (3) summary
    sd00033
    Location:6282
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:5480
    LRRNT; Leucine rich repeat N-terminal domain
    cl26018
    Location:70298
    NEL; C-terminal novel E3 ligase, LRR-interacting
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