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Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13106, updated on 18-Jun-2024

Summary

Official Symbol
Cyp2e1provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily e, polypeptide 1provided by MGI
Primary source
MGI:MGI:88607
See related
Ensembl:ENSMUSG00000025479 AllianceGenome:MGI:88607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp2e; CYPIIE1
Summary
Enables monooxygenase activity. Acts upstream of or within response to bacterium. Located in endoplasmic reticulum. Is expressed in several structures, including cardiovascular system; exocrine gland; foregut; liver and biliary system; and white fat. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 981.7), subcutaneous fat pad adult (RPKM 122.6) and 2 other tissues See more
Orthologs
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Genomic context

See Cyp2e1 in Genome Data Viewer
Location:
7 F4; 7 85.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140343732..140354903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140763819..140774990)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily A member 26 Neighboring gene olfactory receptor family 13 subfamily S member 1, pseudogene 1 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene predicted gene, 29799 Neighboring gene zinc finger protein 941

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4-nitrophenol 2-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in 4-nitrophenol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid hydroxylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in monoterpenoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2E1
Names
4-nitrophenol 2-hydroxylase
cytochrome P450, 2e1, ethanol inducible
cytochrome P450-ALC
cytochrome P450-J
NP_067257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021282.3NP_067257.1  cytochrome P450 2E1

    See identical proteins and their annotated locations for NP_067257.1

    Status: VALIDATED

    Source sequence(s)
    AC107815
    Consensus CDS
    CCDS21985.1
    UniProtKB/Swiss-Prot
    Q05421, Q9Z198
    UniProtKB/TrEMBL
    A0A1B0GSV7
    Related
    ENSMUSP00000026552.8, ENSMUST00000026552.9
    Conserved Domains (1) summary
    pfam00067
    Location:44489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140343732..140354903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)