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CYP2E1 cytochrome P450 family 2 subfamily E member 1 [ Homo sapiens (human) ]

Gene ID: 1571, updated on 6-Sep-2021

Summary

Official Symbol
CYP2E1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily E member 1provided by HGNC
Primary source
HGNC:HGNC:2631
See related
Ensembl:ENSG00000130649 MIM:124040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPE1; CYP2E; P450-J; P450C2E
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 2134.3) See more
Orthologs
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Genomic context

See CYP2E1 in Genome Data Viewer
Location:
10q26.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133527363..133539123)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135340867..135352627)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378575 Neighboring gene uncharacterized LOC107984284 Neighboring gene CYP2E1 5' regulatory region Neighboring gene synaptonemal complex central element protein 1 Neighboring gene shadow of prion protein pseudogene 1 Neighboring gene olfactory receptor family 6 subfamily L member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Knockdown of NOX2 and NOX4 by siRNA abrogates HIV-1 gp120-induced reactive oxygen species (ROS), suggesting that NOX2 and NOX4 are involved in ROS production through CYP2E1 in astrocytes PubMed
env HIV-1 gp120 upregulates the expression of cytochrome p450 family proteins CYP2E1, CYP2D6, and CYP2B6 in astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SYCE1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4-nitrophenol 2-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp90 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxygen binding TAS
Traceable Author Statement
more info
PubMed 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in 4-nitrophenol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in benzene metabolic process TAS
Traceable Author Statement
more info
 
involved_in carbon tetrachloride metabolic process TAS
Traceable Author Statement
more info
 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in halogenated hydrocarbon metabolic process TAS
Traceable Author Statement
more info
 
involved_in heterocycle metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in monoterpenoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ozone IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intrinsic component of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytochrome P450 2E1
Names
4-nitrophenol 2-hydroxylase
CYPIIE1
cytochrome P450, family 2, subfamily E, polypeptide 1
cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
cytochrome P450-J
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000764.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008383.1 RefSeqGene

    Range
    5001..16761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000773.4NP_000764.1  cytochrome P450 2E1 precursor

    See identical proteins and their annotated locations for NP_000764.1

    Status: REVIEWED

    Source sequence(s)
    AL161645, BX951478, J02625
    Consensus CDS
    CCDS7686.1
    UniProtKB/Swiss-Prot
    P05181
    Related
    ENSP00000252945.3, ENST00000252945.8
    Conserved Domains (1) summary
    pfam00067
    Location:33489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133527363..133539123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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